Amino acid neurotransmitter metabolism in neurones and glia following kainate injection in rats

Neuroscience Letters

Volumn 279, Issue 3, 2000, Pages 169-172

  Müller, Bernd ^a   Qu, Hong ^b,c   Gårseth, Mari ^a   White, Linda R ^a   Aasly, Jan ^a   Sonnewald, Ursula ^b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c SINTEF   (Norway)

Author keywords

aminobutyric acid; Epilepsy; Glutamate; Kainic acid; Metabolism; MR spectroscopy

Indexed keywords

4 AMINOBUTYRIC ACID; ACETIC ACID; ASPARTIC ACID; GLUCOSE; GLUTAMIC ACID; KAINIC ACID; NEUROTRANSMITTER; SUCCINIC ACID;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL ACTIVITY; CELL METABOLISM; CONTROLLED STUDY; EPILEPSY; GLIA CELL; GLUCOSE METABOLISM; MALE; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EPILEPSY; KAINIC ACID; MALE; NEUROGLIA; NEURONS; NEUROTRANSMITTER AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0343851674     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00983-0     Document Type: Article

References (15)

1. Aasly J., Silfvenius H., Aas T.C., Sonnewald U., Unsgård G., White L.R. Proton magnetic resonance spectroscopy of brain biopsies from patients with intractable epilepsy. Epilepsy Res. 35:1999;211-217.
2. Bradford H.F. Glutamate, GABA and epilepsy. Prog. Neurobiol. 47:1995;477-511.
3. 13C NMR. J. Biol. Chem. 265:1990;12916-12926.
4. 13C NMR spectroscopy study. J. Neurochem. 65:1995;2773-2782.
5. Hassel B., Bachelard H., Fonnum F., Sonnewald U. Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. J. Cereb. Blood Flow Metab. 17:1997;1230-1238.
6. Hertz L. Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters. Prog. Neurobiol. 13:1979;277-323.
7. Hosford D.A. Models of primary generalized epilepsy. Curr. Opin. Neurol. 8:1995;121-125.
8. 13C NMR spectroscopy: a novel approach to the study of MCA occlusion in rat. J. Cereb. Blood Flow Metab. 18:1998;1223-1232.
9. Khurgel M., Ivy G.O. Astrocytes in kindling: relevance in epileptogenesis. Epilepsy Res. 26:1996;163-175.
10. Schousboe A., Westergaard N., Sonnewald U., Petersen S.B., Huang R., Peng L., Hertz L. Glutamate and glutamine metabolism and compartmentation in astrocytes. Dev. Neurosci. 15:1993;359-366.
11. Schwarzer C., Sperk G. Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat. Neuroscience. 69:1995;705-709.
12. Shank R.P., Bennett G.S., Freytag S.O., Campbell G.L. Pyruvate carboxylase: an astrocytic specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res. 329:1985;364-367.
13. 13C MRS analysis. Dev. Neurosci. 18:1996;434-442.
14. Waniewski R.A., Martin D.L. Preferential utilization of acetate by astrocytes is attributable to transport. J. Neurosci. 18:1998;5225-5233.
15. Yu A.C.H., Drejer J., Hertz L., Schousboe A. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J. Neurochem. 41:1983;1484-1487.