A galanin-mastoparan chimeric peptide activates the Na+,K+-ATPase and reverses its inhibition by ouabain

Regulatory Peptides

Volumn 62, Issue 1, 1996, Pages 47-52

  Langel, Ülo ^a   Pooga, Margus ^a,b   Kairane, Czeslava ^c   Zilmer, Mihkel ^c   Bartfai, Tamas ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

^c UNIVERSITY OF TARTU   (Estonia)

Author keywords

Amphiphilic helix; Galanin; Mastoparan; Na+,K+ ATPase; Receptor

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; CHIMERIC PROTEIN; GALANIN; GALANIN DERIVATIVE; GALANIN RECEPTOR; GALPARAN; MASTOPARAN; NEUROPEPTIDE; OUABAIN; UNCLASSIFIED DRUG; WASP VENOM;

ANIMAL TISSUE; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; FRONTAL CORTEX; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FRONTAL LOBE; GALANIN; LETHAL DOSE 50; MOLECULAR SEQUENCE DATA; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; PEPTIDES; RATS; RATS, WISTAR; RECEPTORS, GALANIN; RECEPTORS, GASTROINTESTINAL HORMONE; RECOMBINANT FUSION PROTEINS; SWINE; WASP VENOMS;

EID: 0029932333     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-0115(96)00002-X     Document Type: Article

References (25)

1. +-pump. FEBS Lett., 268 (1990) 314-328.
2. +-ATPase from porcine intestine. Biochem. Biophys. Res. Commun., 164 (1989) 496-502.
3. Eng, S., Clough, D. and Lo, C., Mastoparan inhibits rat renal Na,K-ATPase. Life Sci., 47 (1990) 2451-2458.
4. Raynor, R.L., Zheng, B. and Kuo, J.F., Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin. J. Biol. Chem., 266 (1991) 2753-2758.
5. +-ATPase. Two mechanisms of stimulation. J. Biol. Chem., 266 (1991) 15824-15831.
6. Fehlmann, M. and Freychet, P., Insulin and glucagon stimulation of (Na+,K+)-ATPase transport activity in isolated rat hepatocytes. J. Biol, Chem., 256 (1981)
7. Kairane, C., Zilmer, M., Mutt, V. and Sillard, R., Activation of Na,K-ATPase by an endogenous peptide, PEC-60. FEBS Lett., 345 (1994) 1-4.
8. Brazy, P.C., Trellis, D.R. and Klotman, P.E., Bradykinin stimulation of oxidative metabolism in renal cortical tubules from rabbit. Possible role of arachidonic acid. J. Clin. Invest., 76 (1985) 1812-1818.
9. Wojtkowiak, R., Turska, E., Lachowicz, L. and Koziolkiewicz, W., Effects of N- and C-termiual fragments of substance P on ATPase and monoamine oxidase activities in rat brain. Gen. Pharmacol., 21 (1990) 403-406.
10. Bartfai, T., Hökfelt, T. and Langel, Ü., Galanin - a neuroendocrine peptide. Crit. Rev. Neurobiol., 7 (1993) 229-274.
11. Bartfai, T., Bedecs, K., Land, T., Langel, Ü., Bertorelli, R., Girotti, P., Consolo, S., Xu, X.J., Wiesenfeld-Hallin, Z., Nilsson, S., Pieribone, V.A. and Hökfelt, T., M-15 - High-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus and spinal cord. Proc. Natl. Acad. Sci. USA, 88 (1991) 10961-10965.
12. Okano, Y., Takagi, H., Tohmatsu, T., Nakashima, S., Kuroda, Y., Saito, K. and Nozawa, Y., A wasp venom mastoparan-induced polyphosphoinositide breakdown in rat peritoneal mast cells. FEBS Lett., 188 (1985) 363-366.
13. 2 activity by mastoparans, a new class of mast cell degranulating peptides from wasp venom. J. Biol. Chem., 258 (1983) 13697-13702.
14. Aridor, M., Traub, L.M. and Sagi-Eisenberg, R., Exocytosis in mast cells by basic secretagogues. Evidence for direct activation of GTP-binding proteins. J. Cell Biol., 111 (1990) 909-917.
15. Shin, Y., Moni, R.W., Lueders, J.E. and Daly, J.W., Effects of amphiphilic peptides mastoparan and adenoregulin on receptor binding, G-proteins, phosphoinositide breakdown, cyclic AMP generation and calcium influx. Cell. Mol. Neurobiol., 14 (1994) 133-157.
16. Land, T., Langel, Ü., Löw, M., Berthold, M., Undén, A. and Bartfai, T., Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor. Int. J. Peptide Protein Res., 38 (1991) 267-272.
17. 2 as a lipophilic modulator of Na-pump. Quest. Med. Chem. (Russ.), 31 (1985) 84-87.
18. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J., Protein measurement with the folin phenol reagent. J. Biol. Chem., 193 (1951) 265-275.
19. Salum, T., Zilmer, M., Kullisaar, T., Vihalemm, T. and Tähepöld, L., Cooperative interactions of Na,K-ATPase with Na and K and its oligomeric structure. Ukr. Biochem. J., 60 (1988) 47-52.
20. Cornish-Bowden, A., In: Fundamentals of enzyme kinetics, 1979, pp. 200-211.
21. Land, T., Langel, Ü., Fisone, G., Bedecs, K. and Bartfai, T., Assay for galanin receptor. Methods Neurosci., 5 (1991) 225-234.
22. 50) of an enzymatic reaction. Biochem. Pharmacol., 22 (1973) 3099-3108.
23. Mousli, M., Bueb, J.-L., Bronner, C., Rouot, B. and Landry, Y., G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. Trends Pharmacol. Sci., 11 (1990) 358-362.
24. Raynor, R., Kim, Y.-S., Zheng, B., Vogler, W. and Kuo, J., Membrane interactions of mastoparan analogues related to their differential effects on protein kinase C, Na,K.ATPase and HL60 cells. FEBS Lett., 307 (1992) 275-279.
25. Boldyrev, A.A., In: Biomembranes and Transport of Ions (Russ. Ed. Krans, E.I), Moscow University Press), 1985, p. 207.