Characterisation and specificity of two single-chain Fv antibodies directed to the protein tyrosine kinase Syk

Journal of Immunological Methods

Volumn 236, Issue 1-2, 2000, Pages 105-115

  Péneff, Caroline ^a   Lefranc, Marie Paule ^a,b   Dariavach, Piona ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^b INSTITUTE OF HUMAN GENETICS   (France)

Author keywords

Phage display library; Protein tyrosine kinase Syk; Single chain Fv

Indexed keywords

COMPLEMENTARY DNA; ENZYME ANTIBODY; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN FRAGMENT; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; BACTERIOPHAGE; BINDING AFFINITY; CELL LINE; CONTROLLED STUDY; DNA LIBRARY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RECOMBINANT DNA TECHNOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CROSS REACTIONS; DNA PRIMERS; ENZYME PRECURSORS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOGLOBULIN FRAGMENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PEPTIDE LIBRARY; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN-TYROSINE KINASES; RABBITS; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0343484991     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(99)00228-8     Document Type: Article

References (25)

1. Arpaia E., Shahar M., Dadi H., Cohen A., Roifman C.M. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase. Cell. 76:1994;947.
2. Chan A.C., Kadlecek T.A., Elder M.E., Filipovich A.H., Kuo W.L., Iwashima M., Parslow T.G., Weiss A. Zap-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science. 264:1994;1599.
3. Cheng A.M., Rowley B., Pao W., Hayday A., Bolen J.B., Pawson T. Syk tyrosine kinase required for mouse viability and B-cell development. Nature. 378:1995;303.
4. Elder M.E., Lin D., Clever J., Chan A.C., Hope T.J., Weiss A., Parslow T.G. Human severe combined immunodeficiency due to a defect in Zap-70, a T cell tyrosine kinase. Science. 264:1994;1596.
5. Flück M., Zurcher G., Andres A.C., Ziemiecki A. Molecular characterization of the murine Syk protein tyrosine kinase cDNA, transcripts and protein. Biochem. Biophys. Res. Commun. 213:1995;273.
6. Griffiths A.D., Malmqvist M., Marks J.D., Bye J.M., Embleton M.J., McCafferty J., Baier M., Holliger K.P., Gorick B.D., Hughes-Jones N.C., et al. Human anti-self antibodies with high specificity from phage display libraries. EMBO J. 12:1993;725.
7. Griffiths A.D., Williams S.C., Hartley O., Tomlinson I.M., Waterhouse P., Crosby W.L., Kontermann R.E., Jones P.T., Low N.M., Allison T.J., et al. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13:1994;3245.
8. Hoogenboom H.R., Griffiths A.D., Johnson K.S., Chiswell D.J., Hudson P., Winter G. Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res. 19:1991;4133.
9. Hoogenboom H.R. Mix and match: building manifold binding sites. Nat. Biotechnol. 15:1997;125.
10. Hutchcroft J.E., Geahlen R.L., Deanin G.G., Oliver J.M. Fc epsilon RI mediated tyrosine phosphorylation and activation of the 72-kDa protein tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc. Natl. Acad. Sci. USA. 89:1992;9107.
11. Kimura T., Sakamoto H., Appella E., Siraganian R.P. Conformational changes induced in the protein tyrosine kinase p72Syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. Mol. Cell. Biol. 16:1996;1471.
12. Lankar D., Briken V., Adler K., Weiser P., Cassard S., Blank U., Viguier M., Bonnerot C. Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation. J. Exp. Med. 188:1998;819.
13. Law C.L., Chandran K.A., Sidorenko S.P., Clark E.A. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell. Biol. 16:1996;1305.
14. Negishi I., Motoyama N., Nakayama K., Nakayama K., Senju S., Hatakeyama S., Zhang Q., Chan A.C., Loh D.Y. Essential role for Zap-70 in both positive and negative selection of thymocytes. Nature. 376:1995;435.
15. Neumeister E.N., Zhu Y., Richard S., Terhorst C., Chan A.C., Shaw A.S. Binding of Zap-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell. Biol. 15:1995;3171.
16. Persic L., Roberts A., Wilton J., Cattaneo A., Bradbury A., Hoogenboom H.R. An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries. Gene. 187:1997;9.
17. Rowley R.B., Burkhardt A.L., Chao H.G., Matsueda G.R., Bolen J.B. Syk protein tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. J. Biol. Chem. 270:1995;11590.
18. Shiue L., Zoller M.J., Brugge J.S. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J. Biol. Chem. 270:1995;10498.
19. 2+ mobilization through distinct pathways. EMBO J. 13:1994;1341.
20. Taylor J.A., Karas J.L., Ram M.K., Green O.M., Seidel-Dugan C. Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domains. Mol. Cell. Biol. 15:1995;4149.
21. Turner M., Mee P.J., Costello P.S., Williams O., Price A.A., Duddy L.P., Furlong M.T., Geahlen R.L., Tybulewicz V.L. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 378:1995;298.
22. Van Oers N.S., Weiss A. The Syk/Zap-70 protein tyrosine kinase connection to antigen receptor signalling processes. Semin. Immunol. 7:1995;227.
23. Vaughan T.J., Williams A.J., Pritchard K., Osbourn J.K., Pope A.R., Earnshaw J.C., McCafferty J., Hodits R.A., Wilton J., Johnson K.S. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nat. Biotechnol. 142.8:1996;309.
24. Winter G., Griffiths A.D., Hawkins R.E., Hoogenboom H.R. Making antibodies by phage display technology. Annu. Rev. Immunol. 12:1994;433.
25. Winter G. Synthetic human antibodies and a strategy for protein engineering. FEBS Lett. 430:1998;92.