The psychobiology of posttraumatic stress disorder

Journal of Clinical Psychiatry

Volumn 61, Issue SUPPL. 5, 2000, Pages

  Nutt, David J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTRANSMITTER;

AROUSAL; BRAIN FUNCTION; CONFERENCE PAPER; HUMAN; MENTAL STRESS; NORADRENERGIC SYSTEM; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOBIOLOGY; QUALITY OF LIFE; SEROTONINERGIC SYSTEM; SOCIAL INTERACTION;

BRAIN; GAMMA-AMINOBUTYRIC ACID; GLUTAMATES; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIFE CHANGE EVENTS; NEURAL PATHWAYS; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; SEROTONIN; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL;

EID: 0343341219     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (45)

1. O'Brien M, Nutt D. Loss of consciousness and post-traumatic stress disorder: a clue to aetiology and treatment. Br J Psychiatry 1998;173:102-104
2. Adler A. Neuropsychiatric complications in victims of Boston's Coconut Grove Disaster. JAMA 1943;123:1098-1101
3. Collingridge GL, Bliss TV. Memories of NMDA receptors and LTP. Trends Neurosci 1995;18:54-56
4. Davidson J, Glover V, Clow A, et al. Tribulin in post-traumatic stress disorder. Psychol Med 1988;4:833-836
5. Coupland NJ, Lillywhite A, Bell CE, et al. A pilot controlled study of the effects of flumazenil in posttraumatic stress disorder. Biol Psychiatry 1997; 41:988-990
6. Nutt DJ. Alcohol and the brain: pharmacological insights for psychiatrists. Br J Psychiatry 1999;174:114-119
7. Gelpin E, Bonne O, Peri T, et al. Treatment of recent trauma survivors with benzodiazepines: a prospective study. J Clin Psychiatry 1996;57:390-394
8. Yehuda R. Neuroendocrinology. In: Nutt DJ, Davidson J, Zohar J, eds. Post Traumatic Stress Disorder: Diagnosis, Management and Mechanisms. London, England: Martin Dunitz. In press
9. Perry BD. Neurobiological sequelae of childhood trauma: PTSD in children. In: Murburg MM, ed. Catecholamine Function in PTSD. Washington, DC: American Psychiatric Press; 1994
10. 2-adrenergic binding sites in posttraumatic stress disorder [letter]. Am J Psychiatry 1987;144: 1511-1512
11. Perry BD, Southwick SM, Yehuda R, et al. Adrenergic receptor regulation in post-traumatic stress disorder. In: Giller EL, ed. Biological Assessment and Treatment of Post-Traumatic Stress Disorder. Washington, DC: American Psychiatric Press; 1990:87-114
12. Blanchard EB, Kolb LC, Prins A, et al. Changes in plasma norepinephrine to combat-related stimuli among Vietnam veterans with post traumatic stress disorder. J Nerv Ment Dis 1991;179:371-373
13. Pitman RK, Orr SP, Forgue DF, et al. Psychophysiologic responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders. J Abnorm Psychol 1990;99:49-54
14. Southwick SM, Krystal JH, Morgan CA, et al. Abnormal noradrenergic function in posttraumatic stress disorder. Arch Gen Psychiatry 1993;50: 266-274
15. Southwick SM, Krystal JH, Bremner JD, et al. Noradrenergic and serotoncrgic function in posttraumatic stress disorder. Arch Gen Psychiatry 1997; 54:749-758
16. Viola J, Ditzler T, Batzer W, et al. Pharmacological management of posttraumatic stress disorder: clinical summary of a five-year retrospective study, 1990-1995. Mil Med 1997;162:616-619
17. Harmon RJ, Riggs PD. Clonidine for posttraumatic stress disorder in preschool children. J Am Acad Child Adolesc Psychiatry 1996;35:1247-1249
18. Horrigan JP, Barnhill LJ. The suppression of nightmares with guanfacine [letter]. J Clin Psychiatry 1996;57:371
19. Yatham LN, Sacamano J, Kusumakar V. Assessment of noradrenergic functioning in patients with non-combat-related posttraumatic stress disorder: a study with desmethylimipramine and orthostatic challenges. Psychiatry Res 1996;63:1-6
20. Calogero AE, Bernardini R, Margioris AN, et al. Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami. Peptides 1989;10:189-200
21. van der Kolk BA, Dreyfuss D, Michaels M, et al. Fluoxetine in posttraumatic stress disorder. J Clin Psychiatry 1994;55:517-522
22. Brady KT, Sonne SC, Roberts JM. Sertraline treatment of comorbid posttraumatic stress disorder and alcohol dependence. J Clin Pyschiatry 1995; 56:502-505
23. Rothbaum BO, Ninan PT, Thomas L. Sertraline in the treatment of rape victims with posttraumatic stress disorder. J Trauma Stress 1996;9: 865-871
24. Dow B, Kline N. Antidepressant treatment of posttraumatic stress disorder and major depression in veterans. Ann Clin Psychiatry 1997;9:1-5
25. Davidson JRT. Pharmacotherapy of posttraumatic stress disorder: treatment options, long-term follow-up, and predictors of outcome. J Clin Psychiatry 2000:61(suppl 5):52-56
26. Bremner JD, Licinio J, Darnell A, et al. Elevated CRF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am J Psychiatry 1997;154:624-629
27. Boscarino JA. Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: findings and clinical implications. J Clin Cons Psych 1996;64:191-201
28. Yehuda R, Giller EL, Southwick SM, et al. Hypothalamic-pituitary-adrenal dysfunction in post-traumatic stress disorder. Biol Psychiatry 1991;30: 1031-1048
29. Yehuda FL, Boisoneau D, Lowy MT, et al. Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch Gen Psychiatry 1995;52:583-593
30. Yehuda R, Lowy MT, Southwick SM, et al. Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. Am J Psychiatry 1991;148: 499-504
31. Lowry MT, Gormley GJ, Reder AT. Immune function, glucocorticoid receptor regulation and depression. In: Miller AH, ed. Depressive Disorders and Immunity. Washington, DC: American Psychiatric Association Press; 1989:105-134
32. Yehuda R, Giller EL, Levengood RA, et al. Hypothalamic-pituitary adrenal alterations in PTSD: expanding the stress-response spectrum. In: Friedman MJ, Charney DS, Deutch AY, eds. Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. New York, NY: Raven Press; 1995:351-365
33. Kosten TR, Mason JW, Giller EL, et al. Sustained urinary norepinephrine and epinephrine levels in posttraumatic stress disorder. Psychoneuroendocrinology 1987;12:13-20
34. Yehuda K, Southwick SM, Ma X, et al. Urinary catecholamine excretion and severity of symptoms in PTSD. J Nerv Ment Dis 1992;180:321-325
35. Mason J, Southwick S, Yehuda R, et al. Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder. Arch Gen Psychiatry 1994;51:629-641
36. Kosten TR, Wahby V, Giller E, et al. The dexamethasone suppression test and thyrotropin-releasing hormone stimulation test in posttraumatic stress disorder. Biol Psychiatry 1990;28:657-664
37. Mason JW, Giller EL, Kosten TR, et al. Serum testosterone levels in posttraumatic stress disorder patients. J Trauma Stress 1990;3:449-457
38. Stein-Behrens B, Mattson MP, Chang I, et al. Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus. J Neurosci 1994;14: 5373-5380
39. Sapolsky RM. The physiological relevance of glucocorticoid endangerment of the hippocampus. Ann N Y Acad Sci 1994;743:294-304
40. Moghaddam B, Bolinao ML, Stein-Behrens B, et al. Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate. Brain Res 1994;65251-254
41. Bodnoff SR, Humphreys AG, Lehman JC, et al. Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J Neurosci 1995;15: 61-69
42. Bremner JD, Randall P, Scott TM, et al. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 1995;152:973-981
43. Bremner JD, Randall P, Vermetten L, et al. MRI-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse: a preliminary report. Biol Psychiatry 1997;41: 23-32
44. Stein MB, Koverola C, Hanna C, et al. Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med 1997;27:951-959
45. Gurvits TV, Shenton ME, Hokama H, et al. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol Psychiatry 1996;40:1091-1099