Anterior tongue stimulation with amiloride suppresses NaCl saltiness, but not citric acid sourness in humans

Chemical Senses

Volumn 21, Issue 2, 1996, Pages 113-120

  Tennissen, Ann M ^a   Bruce McCutcheon, N ^b  

^a College of Saint Rose ^*  (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CITRIC ACID; SODIUM CHLORIDE;

ADULT; ARTICLE; HUMAN; HUMAN EXPERIMENT; PRIORITY JOURNAL; STIMULATION; TASTE; TONGUE;

ADOLESCENT; ADULT; AMILORIDE; CITRIC ACID; FEMALE; HUMANS; MALE; MIDDLE AGED; SODIUM CHLORIDE; TASTE; TASTE BUDS; TONGUE;

EID: 9244237062     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/21.2.113     Document Type: Article

References (28)

1. Bernstein, I.L. and Hennessy, C.J (1987) Amiloride-sensitive sodium channels and expression of sodium appetite in rats. Am.J. Physiol., 253, R371-R374.
2. Brosvic, G.M. and Rowe, M.M. (1992) Methyl xanthine, adenosine, and human taste responsivity. Physiol. Behav., 53, 559-563.
3. Desor, J.A. and Finn, J, (1989) Effects of amiloride on salt taste in humans. Chem. Senses, 14, 793-803.
4. Gilbertson, TA., Avnet, P., Kinnamon, S.C., and Roper, S.D. (1992) Proton currents through amiloride-sensitive Na channels in hamster taste cells. J. Gen. Physiol., 100, 803-824.
5. Halpern, B.P., Kelling, S.T., Davis, J., Dorries, K.M., Haq, A. and Meltzer, J.S. (1992) Effects of amiloride on human taste responses to NaCl: time-intensity and taste quality descriptor measures Chem. Senses, 17, 637.
6. Halpern, B.P., Meltzer, J.S. and Darlington, R.B. (1993) Effects of amiloride on tracked taste intensity and on taste quality description of NaCl: individual differences and dose-response effects. Chem. Senses, 18, 566
7. Hamilton, K.L. and Eaton, D.C. (1985) Single-channel recordings from amiloride-sensitive sodium channels. Am. J. Physiol., 249, (Cell Physiol., 18): C200-C207.
8. Hellekant G., DuBois, G.E., Roberts, T.W and van der Wel, H. (1988) On the gustatory effect of amiloride in the monkey (Macaca mulatta). Chem. Senses, 13, 89-93.
9. Hettinger, T.P. and Frank, M.E. (1990) Specificity of amiloride inhibition of hamster taste responses. Brain Res., 513, 24-34.
10. Hill, D.L., Formaker, B.K and White, K.S. (1990) Perceptual characteristics of the amiloride-suppressed sodium chloride taste response in the rat. Behav. Neurosci., 104, 734-741.
11. Jakinovich, W. (1985) Stimulation of the gerbil's gustatory receptors by methyl glycopyranosides. Chem. Senses, 10, 594-604.
12. Jenkins, J.B. and Tomkins, L (1990) Effects of amiloride on taste responses of Drosphila melanogaster adults and larvae. J. Insect Physiol., 36, 613-618.
13. McCutcheon, N.B. (1991) Sodium deficient rats are unmotivated by sodium chloride solutions mixed with the sodium channel blocker amiloride. Behav. Neurosci., 105, 764-766.
14. McCutcheon, N.B. (1992) Human psychophysical studies of saltiness suppression by amiloride. Physiol. Behav., 51, 1069-1074.
15. McPheeters, M. and Roper, S.D (1985) Amiloride does not block taste transduction in the mudpuppy, Necturus maculosus. Chem. Senses, 10, 341-352.
16. Mierson, S., DeSimone, S.K., Heck, G.L. and DeSimone, J.A. (1988) Sugar-activated ion transport in canine lingual epithelium: implications for sugar taste transduction. J. Gen. Physiol., 92, 87-111.
17. Ninomiya, Y. and Funakoshi, M. (1988) Amiloride inhibition of responses of rat single chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res., 451, 319-325.
18. Ninomiya,Y., Sako, N. and Funakoshi, M.(1989) Strain differences in amiloride inhibition of NaCl responses in mice, Mus musculus. J. Comp. Physiol. A, 166, 1-5.
19. - receptor mechanisms. Chem. Senses, 20, 37-46.
20. Schiffersten, H.N.J. and Fritjers, J.E.R. (1992) Two-stimulus versus one-stimulus procedure in the framework of functional measurement: a comparative investigation using quinine HCl/ NaCl mixtures. Chem. Senses, 17, 127-150.
21. Schiffman, S.S., Lockhead, E. and Maes, F.W (1983) Amiloride reduces the taste intensity of Na and Li salts and sweeteners. Proc. Nat. Acad. Sci. USA, 80, 6136-6140.
22. Schiffman, S.S., Simon, S.A., Gill, J.M. and Beeker, T.J. (1986) Bretylium tosylate enhances salt taste Physiol. Behav, 36, 1129-1137.
23. Schiffman, S. (1987) Salt apppetite, intake, and preference for salt in man and animals. Panel discussion, in: Roper, S.D. and Atema, J. (eds), Taste and Olfaction, IX., Annl NY Acad Sci., 510, 137.
24. Schiffman, S.S., Suggs, M.S., Sostman, A.L. and Simon, S.A. (1991) Chorda tympani and lingual nerve responses to astringent compounds in rodents. Physiol. Behav., 51, 55-63.
25. Scott, T.R. and Giza, B.K. (1990) Coding channels in the taste system of the rat. Science, 249, 1585-1587.
26. Smith, D. and Van Der Klaauw, N. (1993) Cross adaptation to NaCl-implications for the coding of saltiness, abstract. Association for Chemoreception Sciences Meeting, Sarasota, FL.
27. Tennissen, A.M. (1991) Investigations of human taste response using microdrop stimulation of fungiform papillae Ph.D Thesis, SUNY, Albany, NY.
28. Tennissen, A.M. (1992) Amiloride reduces intensity responses in human fungiform papillae. Physiol Behav., 51, 1062-1068.