Structure of the Ser195Ala mutant of human α-thrombin complexed with fibrinopeptide A(7-16): Evidence for residual catalytic activity

Acta Crystallographica Section D: Biological Crystallography

Volumn 56, Issue 4, 2000, Pages 406-410

  Krishnan, R ^a,c   Sadler, J Evan ^b   Tulinsky, A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DRUG DERIVATIVE; FIBRINOPEPTIDE A; HIRUDIN DERIVATIVE; HIRUGEN; PEPTIDE FRAGMENT; SERINE; THROMBIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; GENETICS; HUMAN; POINT MUTATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SUBSTITUTION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FIBRINOPEPTIDE A; HIRUDINS; HUMANS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; POINT MUTATION; PROTEIN CONFORMATION; SERINE; SOFTWARE; THROMBIN;

EID: 0343238328     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0907444900001487     Document Type: Article

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