Parkinson disease: Analysis of mitochondrial DNA in monozygotic twins

Neurogenetics

Volumn 2, Issue 4, 2000, Pages 227-230

  Kösel, Siegfried ^a   Grasbon Frodl, Eva M ^a   Hagenah, Johann M ^b   Graeber, Manuel B ^c   Vieregge, Peter ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

Complex I; Mitochondrial DNA; Mitochondrial tRNA genes; Neurodegeneration

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DNA DETERMINATION; GENE SEQUENCE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MISSENSE MUTATION; MOLECULAR GENETICS; MONOZYGOTIC TWINS; PARKINSON DISEASE; PRIORITY JOURNAL;

PARKINSONIA;

EID: 0343130499     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100480050068     Document Type: Article

References (18)

1. Burn DJ, Mark MH, Playford ED, Maraganore DM, Zimmermann TR, Duvoisin RC, Harding AE, Marsden CD, Brooks DJ (1992) Parkinson's disease in twins studied with 18F-dopa and positron emission tomography. Neurology 42:1894-1900
2. Piccini P, Burn DJ, Ceravolo R, Maraganore D, Brooks DJ (1999) The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann Neurol 45:577-582
3. Duvoisin RC (1998) Role of genetics in the cause of Parkinson's disease. Mov Disord 13:7-12
4. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Diiorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276:2045-2047
5. Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kösel S, Przuntek H, Epplen JT, Schöls L, Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18:106-108
6. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605-608
7. Lücking CB, Abbas N, Durr A, Bonifati V, Bonnet AM, Broucker T de, De Michele G, Wood N W, Agid Y, Brice A (1998) Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. Lancet 352:1355-1356
8. Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, Dehejia A, Lavedan C, Gasser T, Steinbach PJ, Wilkinson KD, Polymeropoulos MH (1998) The ubiquitin pathway in Parkinson's disease. Nature 395:451-452
9. Swerdlow RH, Parks JK, Davis JN, Cassarino DS, Trimmer PA, Currie LJ, Dougherty J, Bridges WS, Bennett JP, Wooten GF, Parker WD (1998) Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family. Ann Neurol 44:873-881
10. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP, Davis RE, Parker WD (1996) Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-671
11. Gu M, Cooper JM, Taanman JW, Schapira AHV (1998) Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann Neurol 44:177-186
12. Vieregge P, Schiffke KA, Friedrich HJ, Müller B, Ludin HP (1992) Parkinson's disease in twins. Neurology 42:1453-1461
13. Vieregge P, Hagenah J, Heberlein I, Klein C, Ludin H-P (1999) Parkinson's disease in twins - a follow-up study. Neurology 53:566-572
14. Kösel S, Grasbon-Frodl EM, Mautsch U, Egensperger R, Eitzen U von, Frishman D, Hofmann S, Gerbitz K-D, Mehraein P, Graeber MB (1998) Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease. Neurogenetics 1:197-204
15. Grasbon-Frodl EM, Kösel S, Sprinzl M, Eitzen U von, Mehraein P, Graeber MB (1999) Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease. Neurogenetics 2:121-127
16. Kogelnik AM, Lott MT, Brown MD, Navathe SB, Wallace DC (1998) MITOMAP: a human mitochondrial genome database - 1998 update. Nucleic Acids Res 26:112-115
17. Torroni A, Petrozzi M, Durbano L, Sellitto D, Zeviani M, Carrara F, Carducci C, Leuzzi V, Carelli V, Barboni P, Denegri A, Scozzari R (1997) Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484. Am J Hum Genet 60:1107-1121
18. Anderson S, Bankier AT, Barrell BG, Bruijn MHL de, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG (1981) Sequence Organisation of the human mitochondrial genome. Nature 290:457-465