Gemfibrozil and its oxidative metabolites: Quantification of aglycones, acyl glucuronides, and covalent adducts in samples from preclinical and clinical kinetic studies

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 741, Issue 2, 2000, Pages 129-144

  Hermening, Andreas ^a   Gräfe, Ann Katrin ^a   Baktir, Gül ^b   Mutschler, Ernst ^a   Spahn Langguth, Hildegard ^c  

^a GOETHE UNIVERSITY   (Germany)

^b ISTANBUL UNIVERSITY   (Turkey)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Acyl glucuronides; Aglycones; Gemfibrozil

Indexed keywords

BUMETANIDE; DRUG METABOLITE; GEMFIBROZIL; PIRETANIDE;

ACCURACY; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; COVALENT BOND; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG TISSUE LEVEL; DRUG URINE LEVEL; GLUCURONIDATION; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; HYPERLIPIDEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TECHNIQUE; TISSUE HOMOGENATE;

ANIMALS; ANTILIPEMIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GEMFIBROZIL; GLUCURONIDES; HUMANS; HYPERLIPIDEMIAS; RATS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 0343091510     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(00)00041-4     Document Type: Article

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