Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: Implications for the mechanism of polymerase action

Protein Engineering

Volumn 10, Issue 12, 1997, Pages 1379-1383

  Kroeger Smith, Marilyn B ^a   Michejda, Christopher J ^a   Hughes, Stephen H ^a   Boyer, Paul L ^a   Janssen, Paul A J ^b   Andries, Koen ^b   Buckheit Jr , Robert W ^c   Smith Jr , Richard H ^a,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

^d WESTERN MARYLAND COLLEGE   (United States)

Author keywords

AIDS; Computer; Inhibitor; Resistance; Reverse transcriptase

Indexed keywords

ACETAMIDE DERIVATIVE; ALPHA ANILINO 2,6 DIBROMOPHENYLACETAMIDE; DNA POLYMERASE; MUTANT PROTEIN; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TIVIRAPINE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; ENZYME STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT;

EID: 0342908170     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/10.12.1379     Document Type: Article

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