Impaired inhibition of epileptiform activity by baclofen, but not by adenosine in the weaver hippocampus

Neuropharmacology

Volumn 39, Issue 2, 2000, Pages 246-253

  Jarolimek, Wolfgang ^a   Bäurle, Jörg ^b   Misgeld, Ulrich ^c  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adenosine; G protein activated potassium currents; GABA(B) receptors; Kir3.2; R baclofen; Weaver

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; BACLOFEN; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN SLICE; CHANNEL GATING; CONTROLLED STUDY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; MOUSE; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL;

4-AMINOPYRIDINE; ADENOSINE; ANALGESICS; ANIMALS; BACLOFEN; DRUG INTERACTIONS; FEMALE; GABA AGONISTS; GABA ANTAGONISTS; HIPPOCAMPUS; MALE; MICE; MICE, INBRED CBA; MICE, NEUROLOGIC MUTANTS; PHOSPHINIC ACIDS; PROPANOLAMINES; RECEPTORS, GABA-B;

EID: 0342546417     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00089-1     Document Type: Article

References (26)

1. 1 receptor-mediated inhibitory tonus: pre- and postsynaptic components. Neuroscience. 57:1993;565-575.
2. Ault B., Wang C.M. Adenosine inhibits epileptiform activity arising in hippocampal area CA3. British Journal of Pharmacology. 87:1986;695-703.
3. B antagonists. Pharmacological Communications. 2:1992;52-56.
4. Greene R.W., Haas H.L. The electrophysiology of adenosine in the mammalian central nervous system. Progress in Neurobiology. 36:1991;329-341.
5. B currents in granule cells of the guinea-pig hippocampus. Pflügers Archiv. 425:1993;491-498.
6. Jarolimek W., Demmelhuber J., Bijak M., Misgeld U. CGP 55845A blocks baclofen, γ-aminobutyric acid and inhibitory postsynaptic potassium currents in guinea pig CA3 neurons. Neuroscience Letters. 154:1993;31-34.
7. +-dependent inhibition in weaver hippocampus. Journal of Neuroscience. 18:1998;4001-4007.
8. B receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386:1997;239-246.
9. Kenakin T.P. Effects of equilibration time on the attainment of equilibrium between antagonists and drug receptors. European Journal of Pharmacology. 66:1980;295-306.
10. Kenakin T. The classification of seven transmembrane receptors in recombinant expression systems. Pharmacological Reviews. 48:1996;413-463.
11. Knutsson E., Lindblom U., Martensson A. Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis. Journal of Neurological Science. 23:1974;473-484.
12. 2+. Brain Research. 547:1991;349-352.
13. + channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. Journal of Neuroscience. 16:1996;7137-7150.
14. + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron. 19:1997;687-695.
15. Misgeld U., Sarvey J.M., Klee M.R. Heterosynaptic postactivation potentiation in hippocampal CA3 neurons: long-term changes of the postsynaptic potentials. Experimental Brain Research. 37:1979;217-229.
16. B receptors and the effects of baclofen in the mammalian central nervous system. Progress in Neurobiology. 46:1995;423-462.
17. K,GABA in guinea pig hippocampal slices. Neuroscience Letters. 102:1989;229-234.
18. B receptor antagonists on GABAergic transmission in vivo and in vitro. European Journal of Pharmacology. 233:1993;179-186.
19. Patil N., Cox D.R., Bhat D., Faham M., Myers R.M., Peterson A.S. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nature Genetics. 11:1995;126-129.
20. Penn R.D., Savoy S.M., Corcos D., Latash M., Gottlieb G., Parke B., Kroin J.S. Intrathecal baclofen for severe spinal spasticity. New English Journal of Medicine. 320:1989;1517-1521.
21. Schubert P., Ogata T., Marchini C., Ferroni S., Rudolphi K. Protective mechanisms of adenosine in neurons and glial cells. Annals of the New York Academy of Sciences. 825:1997;1-10.
22. Sekiguchi M., Nowakowski R.S., Nagato Y., Tanaka O., Guo H., Madoka M., Abe H. Morphological abnormalities in the hippocampus of the weaver mutant mouse. Brain Research. 696:1995;262-267.
23. Swartzwelder H.S., Bragdon A.C., Sutch C.P., Ault B., Wilson W.A. Baclofen suppresses hippocampal epileptiform activity at low concentrations without suppressing synaptic transmission. Journal of Pharmacology and Experimental Therapeutics. 237:1986;881-887.
24. Thompson S.M., Capogna M., Scanziani M. Presynaptic inhibition in the hippocampus. Trends in Neuroscience. 16:1993;222-227.
25. B receptors in physiology and pathology. Neuropsychopharmacology. 6:1992;201-214.
26. Wu L.-G., Saggau P. Presynaptic inhibition of elicited neurotransmitter release. Trends in Neuroscience. 20:1997;204-212.