Are ovine leydig cells able to aromatize androgens?

Reproduction, Fertility and Development

Volumn 9, Issue 2, 1997, Pages 193-199

  Bilińska, Barbara ^a   Leśniak, Marcin ^a   Schmalz, Barbara ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Aromatase; Immunohistochemistry; In vitro; Inhibitor aromatase; Ram

Indexed keywords

ANDROGEN; AROMATASE; AROMATASE INHIBITOR; ESTRADIOL; FADROZOLE; TESTOSTERONE;

ANIMAL CELL; ANIMAL TISSUE; AROMATIZATION; ARTICLE; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; MALE; RADIOIMMUNOASSAY; SHEEP; TESTIS; TESTOSTERONE RELEASE; TESTOSTERONE SYNTHESIS;

ANDROGENS; ANIMALS; AROMATASE; AROMATASE INHIBITORS; CELLS, CULTURED; ENZYME INHIBITORS; ESTRADIOL; FADROZOLE; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; LEYDIG CELLS; MALE; SHEEP; TESTOSTERONE;

ANIMALIA; OVIS; OVIS ARIES;

EID: 0342506838     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/R96038     Document Type: Article

References (43)

1. Almadhidi, J., Seralini, G.-E., Fresnel, J., Silberzahn, P., and Gaillard, J.-L. (1995). Immunohistochemical localization of cytochrome P450 aromatase in equine gonads. J. Histochem. Cytochem. 43, 571-7.
2. Almahbobi, G., Papadopoulos, V., Carreau, S., and Silberzahn, P. (1988). Age-related morphological and functional changes in the Leydig cells of the horse. Biol. Reprod. 38, 653-62.
3. Amri, H., Gaillard, J.-L., Al-Timimi, I., and Silberzahn, P. (1993). Equine ovarian aromatase: evidence for a species specificity. Biochem. Cell. Biol. 71, 296-307.
4. 5,3β-hydroxysteroid dehydrogenase activity in cultured Leydig cells under the influence of gonadotropic hormones and testosterone. Int. J. Androl. 2, 382-94.
5. Bilińska, B., and Litwin, J. A. (1995). Immunocytochemical demonstration of peroxisomes in cultured Leydig cells: a decrease in testosterone secretion precedes reduction of peroxisomes. Eur. J. Histochem. 39, 273-80.
6. Brodie, A., and Inkster, S. (1993). Aromatase in the human testis. J. Steroid Biochem. Mol. Biol. 44, 549-55.
7. Carreau, S., Papadopoulos, V., and Drosdowsky, M. A. (1988). Stimulation of adult rat Leydig cell aromatase activity by Sertoli cell factor. Endocrinology 122, 1103-9.
8. Ciocca, D. R., Winters, C. A., and Dufau, M. L. (1986). Expression of an estrogen-regulated protein in rat testis Leydig cells. J. Steroid Biochem. 24, 219-29.
9. Conley, A. J., Corbin, C. J., Hinshelwood, M. M., Liu, Z., Simpson, E. R., Ford, J. J., and Harada, N. (1996). Functional aromatase expression in porcine adrenal gland and testis. Biol. Reprod. 54, 497-505.
10. Dellovade, T. L., Rissman, E. F., Thompson, N., Harada, N., and Ottinger, M. A. (1995). Co-localization of aromatase enzyme and estrogen receptor immunoreactivity in the preoptic area during reproductive aging. Brain Res. 674, 181-7.
11. Dufau, M. L., Catt, K. J., Tsuruhara, T., and Ryan, D. (1972). Radioimmunoassay of plasma testosterone. Clin. Chim Acta 37, 109-16.
12. Eisenhauer, K. M., McCue, P. M., Nayden, D. K., Osawa, Y., and Roser, J. F. (1994). Localization of aromatase in equine Leydig cells. Domest. Anim. Endocrinol. 11, 291-8.
13. Habert, R., and Brignaschi, P. (1991). Developmental changes during fetal life in rats. Arch. Androl. 27, 65-71.
14. Hotchkiss, J., Atkinson, L. E., and Knobil, E. (1971). Time course of serum estrogen and luteinizing hormone concentrations during menstrual cycle of rhesus monkey. Endocrinology 89, 177-83.
15. Inkster, S. E., and Brodie, A. M. H. (1989). Immunocytochemical localization of aromatase in early and full-term human placental tissues: comparison with biochemical assays. Biol. Reprod. 41, 889-93.
16. Inkster, S., Yue, W., and Brodie, A. M. H. (1995). Human testicular aromatase: immunocytochemical and biochemical studies. J. Clin. Endocrinol. & Metab. 80, 1941-7.
17. Ishimura, K., Yoshinaga-Hirabayashi, T., Tsuri, H., Fujita, H., and Osawa, Y. (1989). Further immunocytochemical study on the localization of aromatase in the ovary of rats and mice. Histochemistry 90, 413-16.
18. Jakob, F., Homann, D., Schneider, D., and Kohrle, J. (1995). Expression and regulation of aromatase cytochrome P450 in THP 1 human myeloid leukaemia cells. Mol. Cell. Endocrinol. 110, 27-33.
19. arom which decreases as sperm traverse the epididymis. J. Androl. 17, 111-16.
20. Kmicikiewicz, I., Krȩzȯłek, A., and Bilińska, B. (1997). The effect of aromatase inhibitor on basal and testosterone-supplemented estradiol secretion by Leydig cells in vitro. Exp. Clin. Endocrinol. & Diabetes 105, 113-18.
21. Kurosumi, M., Ishimura, K., Fujita, H., and Osawa, Y. (1985). Immunocytochemical localization of aromatase in rat testis. Histochemistry 83, 401-4.
22. Kwon, S., Hess, R. A., Bunick, D., Nitta, H., Janulis, L., Osawa, Y., and Bahr, J. M. (1995). Rooster germ cells and epididymal sperm contain P450 aromatase. Biol. Reprod. 53, 1259-64.
23. Matzkin, H., and Soloway, M. S. (1992). Immunocytochemical evidence of the existence and localization of aromatase in human prostatic tissues. Prostate 21, 309-17.
24. Nitta, H., Bunick, D., Hess, R. A., Janulis, L., Newton, S. C., Milette, C. F., Osawa, Y., Shizuta, Y., Toda, K., and Bahr, J. M. (1993). Germ cells of the mouse testis express P450 aromatase. Endocrinology 132, 1396-401.
25. Payne, A., Perkins, L. M., Georgiou, M., and Quinn, P. G. (1987). Intratesticular site of aromatase activity and possible function of testicular estradiol. Steroids 50, 435-48.
26. Pomerantz, D. K. (1983). Interactions of follicle-stimulating hormone and luteinizing hormone in controlling estradiol synthesis by the testis of the infant rat. Biol. Reprod. 28, 890-6.
27. Raeside, J. I., Wilkinson, C. R., and Farkas, G. (1993). Ontogenesis of estrogen secretion by porcine fetal testis. Acta Endocrinol. 128, 549-54.
28. Riguadière, N., Grizard, G., and Boucher, D. (1989). Aromatase activity in purified Leydig cells from adult rat. Comparative effects of insulin, IGF-I and hCG. Acta Endocrinol. 121, 677-85.
29. Robel, P. (1993). Steroidogenesis: the enzymes and regulation of their genomic expression. In 'Reproduction in Mammals and Man'. (Eds C. Thibault, M. C. Levasseur and R. H. F. Hunter.) pp. 136-42. (Ellipses: Paris.)
30. Rommerts, F. F. G., De Jong, F. H., Brinkmann, A. O., and Van der Molen, H. J. (1982). Developmental and cellular localization of rat testicular aromatase activity. J. Reprod. Fertil. 65, 281-8.
31. Saez, J. M., Sanchez, P., Berthelon, M. C., and Avallet, O. (1989). Regulation of pig Leydig cell aromatase activity by gonadotropins and Sertoli cells. Biol. Reprod. 41, 813-20.
32. Schteingart, H. F., Meroni, S. B., Pellizzari, E. H., Loaiza-Perez, A., and Cigorraga, S. B. (1995). Regulation of Sertoli cell aromatase activity by cell density and prolonged stimulation with FSH, EGF, insulin and IGF-I at different moments of pubertal development. J. Steroid Biochem. Mol. Biol. 52, 375-81.
33. Silberzahn, P., Gaillard, J.-L., Quincey, D., Dintinger, T., and Al-Timmi, I. (1988). Aromatization of testosterone and 19-nortestosterone by a single enzyme from equine testicular microsomes. Differences from human placental aromatase. J. Steroid Biochem. 29, 119-27.
34. Simpson, E. R., Mahendroo, M. S., Means, G. D., Kilgore, M. W., Hinhelwood, M. M., Graham-Lorence, S., Amarneh, B., Ito, Y., Fisher, C. R., Michael, M. D., Mendelson, C. R., and Bulun, S. E. (1994). Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocrinol. Rev. 15, 342-55.
35. Steele, R. E., Mellor, L. B., Sawyer, W. K., Wasvery, J. M., and Browne, L. J. (1987). In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal artomatase inhibitor CGS 16949A. Steroids 50, 147-61.
36. Tsai-Morris, C., Aquiano, D. R., and Dufau, M. L. (1985). Cellular localization of rat testicular aromatase activity during development. Endocrinology 116, 38-46.
37. arom in the hokkaido brown bear (Ursus arctos yesoensis) testis. Gen. Comp. Endocrinol. 92, 439-47.
38. Valladares, L., and Payne, A. H. (1979). Induction of testicular aromatization by luteinizing hormone in mature rats. Endocrinology 105, 431-6.
39. Valladares, L., and Payne, A. H. (1981). Effects of hCG and cyclic AMP on aromatization in purified Leydig cells of immature and mature rats. Biol. Reprod. 25, 752-8.
40. Walker, U. J., and Nogues, V. (1994). Changes induced by treatment with aromatase inhibitors in testicular Leydig cells of rats and dogs. Exp. Toxicol. Pathol. 46, 211-13.
41. Weniger, J. P. (1990). Aromatase activity in fetal gonads of mammals. Dev. Physiol. 14, 303-6.
42. Yoshinaga-Hirabayashi, T., Ishimura, K., Fujita, H., Kitawaki, J., and Osawa, Y. (1990). Immunocytochemical localization of aromatase in immature rat ovaries treated with PMSG and hCG, and in pregnant rat ovaries. Histochemistry 93, 223-8.
43. Zhong, C., Ishimura, K., Yoshinaga-Hirabayashi, T., Fujita, H., Kitawaki, J., and Osawa, Y. (1989). Immunocytochemical study on the localization of aromatase in the ovary of golden hamster, guinea pig and cow. Acta Histochem. Cytochem. 22, 501-7.