The effect of aromatase inhibitor on basal and testosterone-supplemented estradiol secretion by Leydig cells in vitro

Experimental and Clinical Endocrinology and Diabetes

Volumn 105, Issue 2, 1997, Pages 113-118

  Kmicikiewicz, I ^a   Krezolek A ^a   Bilinska B ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Aromatase; Aromatase inhibitor; Estradiol secretion; In vitro; Leydig cells

Indexed keywords

AROMATASE; AROMATASE INHIBITOR; ESTRADIOL; FADROZOLE; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HORMONE RELEASE; HORMONE SYNTHESIS; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOLOGY;

EID: 0030902346     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211737     Document Type: Article

References (26)

1. Bilińska B: Staining with ANS fluorescent dye reveals distribution of mitochondria and lipid droplets in cultured Leydig cells. Folia Histochem Cytobiol 32: 21-24, 1994
2. Bilińska B, Litwin JA: Immunocytochemical demonstration of peroxisomes in cultured Leydig cells: a decrease in testosterone secretion precedes reduction of peroxisomes. Eur J Histochem 39: 273-280, 1995
3. Carreau S, Papadopoulos V, Drosdowsky MA: Stimulation of adult rat Leydig cell aromatase activity by Sertoli cell factor. Endocrinology 122: 1103-1109, 1988
4. Ciocca DR, Winters CA, Dufau ML: Expression of an estrogen-regulated protein in rat testis Leydig cells. J Steroid Biochem 24: 219-229, 1995
5. Dellovade TL, Rissman EF, Thompson N, Harada N, Ottinger MA: Co-localization of aromatase enzyme and estrogen receptor immunoreactivity in the preoptic area during reproductive aging. Brain Res 674: 181-187, 1995
6. Dufau ML, Catt KJ, Tsuruhara T, Ryan D: Radioimunoassay of plasma testosterone. Clin Chim Acta 37: 109-116, 1972
7. Eisenhauer KM, McCue PM, Nayden DK, Osawa Y, Roser JF: Localization of aromatase in equine Leydig cells. Domestic Anim Endocrinol 11: 291-298, 1994
8. Habert R, Brignaschi P: Developmental changes in vitro testosterone production by dispersed Leydis cells during fetal life in rats. Archiv Androl 27: 65-71, 1991
9. Hotchkiss J, Atkinson LE, Knobil E: Time course of serum estrogen and luteinizing hormone concentrations during menstrual cycle of rhesus monkey. Endocrinology 89: 177-183, 1971
10. Inkster S, Yue W, Brodie A: Human testicular aromatase: immunocytochemical and biochemical studies. J Clin Endocrinol Metab 80: 1941-1947, 1995
11. Ishimura K, Yoshinaga-Hirabayashi T, Tsuri H, Fujita H, Osawa Y: Further immunocytochemical study on the localization of aromatase in the ovary of rats and mice. Histochemistry 90: 413-416, 1989
12. Jakob F, Homann D, Schneider D, Kohrle J: Expression and regulation of aromatase cytochrome P450 in THP 1 human myeloid leukaemia cells. Mol Cell Endocrinol 110: 27-33, 1995
13. Payne AH, Perkins LM, Georgiou M, Quinn PG: Intratesticular site of aromatase activity and possible function of testicular estradiol. Steroids 50: 435-448, 1987
14. Pomerantz DK:Interactions of follicle-stimulating hormone and luteinizing hormone in controlling estradiol synthesis by the testis of the infant rat. Biol Reprod 28: 890-896, 1993
15. Raeside JI, Wilkinson CR, Farkas G: Ontogenesis of estrogen secretion by porcine fetal testes. Acta Endocrinol 128: 549-554, 1993
16. Rigaudiere N, Grizard G, Boucher D: Aromatase activity in purified Leydig cells from adult rat. Comparative effects of insulin, IGF-I and hCG. Acta Endocrinol 121: 677-685, 1989
17. Rommerts FFG, de Jong FH, Brinkmann AO, van der Molen HJ: Developmental and cellular localization of rat testicular aromatase activity. J Reprod Fertil 65: 281-288, 1982
18. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD, Mendelson CR, Bulun SE: Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 15: 342-355, 1994
19. Steele RE, Mellor LB, Sawyer WK, Wasvery JM, Browne LJ: In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949 A. Steroids 50: 147-161, 1987
20. Tsai-Morris C, Aquiano DR, Dufau ML: Cellular localization of rat testicular aromatase activity during development. Endocrinology 116: 38-46, 1985
21. Valladares L, Payne AH: Effects of hCG and cyclic AMP on aromatization in purified Leydig cells of immture and mature rats. Biol Reprod 25: 752-758, 1981
22. Valladares L, Payne AH: Induction of testicular aromatization by luteinizing hormone in mature rats. Endocrinology 105: 431-436, 1979
23. Walker UJ, Nogues V: Changes induced by treatment with aromatase inhibitors in testicular Leydig cells of rats and dogs. Exp Toxic Pathol 46: 211-213, 1994
24. Weniger JP: Aromatase activity in fetal gonads of mammals. J Develop Physiol 14: 303-306, 1990
25. Yoshinaga-Hirabayashi T, Ishimura K, Fujita H, Kitawaki J, Osawa Y: Immunocytochemical localization of aromatase in immature rat ovaries treated with PMSG and hCG, and in pregnant rat ovaries. Histochemistry 93: 223-228, 1990
26. Zhong C, Ishimura K, Yoshinaga-Hirabayashi T, Fujita H, Kitawaki J, Osawa Y: Immunocytochemical study on the localization of aromatase in the ovary of golden hamster, guinea pig and cow. Acta Histochem Cytochem 22: 501-507, 1989