Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder: Two randomised controlled trials

Drug and Alcohol Dependence

Volumn 63, Issue 2, 2001, Pages 187-195

  Pérez De Los Cobos, José ^a   Duro, Pilar ^a   Trujols, Joan ^a   Tejero, Antoni ^a   Batlle, Fanny ^a   Ribalta, Elisa ^a   Casas, Miquel ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Amantadine; Cocaine use disorder; Detoxification; Heroin dependence; Methadone; Opioid withdrawal

Indexed keywords

AMANTADINA LLORENTE; AMANTADINE; COCAINE; DIAMORPHINE; DIAZEPAM; DIAZEPAM PRODES; METHADONE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; COCAINE DEPENDENCE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DETOXIFICATION; DRUG EFFECT; DRUG WITHDRAWAL; FEMALE; HEALTH STATUS; HEROIN DEPENDENCE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; WITHDRAWAL SYNDROME;

ADOLESCENT; ADULT; AMANTADINE; COCAINE-RELATED DISORDERS; COMORBIDITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HEROIN DEPENDENCE; HUMANS; MALE; METHADONE; MIDDLE AGED; NEUROLOGIC EXAMINATION; PATIENT ADMISSION; SUBSTANCE WITHDRAWAL SYNDROME; TREATMENT OUTCOME;

EID: 0342467849     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(00)00206-4     Document Type: Article

References (30)

1. Alterman A.I., Droba M., Antelo R.E., Cornish J.W., Sweeney K.K., Parikh G.A., O'Brien C.P. Amantadine may facilitate detoxification of cocaine addicts. Drug Alcohol Depend. 31:1992;19-29.
2. Alterman A.I., Kampman K., Boardman C.R., Cacciola J.S., Rutherford M.J., McKay J.R., Maany I. A cocaine-positive baseline urine predicts outpatient treatment attrition and failure to attain initial abstinence. Drug Alcohol Depend. 46:1997;79-85.
3. Beck A.T., Ward C.H., Mendelson M., Mock J., Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry. 4:1961;561-571.
4. Buccafusco J.J. Inhibition of the morphine withdrawal syndrome by a novel muscarinic antagonist (4-DAMP). Life Sci. 48:1990;749-756.
5. Danysz W., Parsons C.G., Kornhuber J., Schmidt W.J., Quack G. Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents - preclinical studies. Neurosci. Biobehav. Rev. 21:1997;455-468.
6. Di Chiara G., Morelli M., Consolo S. Modulatory functions of neurotransmitters in the striatum: Ach/dopamine/NMDA interactions. Trends Neurosci. 17:1994;228-233.
7. Eysenck S.B.G., Pearson P.R., Easting G., Allsop J.G. Age norms for impulsiveness, venturesomeness and empathy in adults. Pers. Individ. Differ. 6:1985;614-619.
8. Giannini A.J., Folts D.J., Feather J.N., Sullivan B.S. Bromocriptine and amantadine in cocaine detoxification. Psychiatry Res. 29:1989;11-16.
9. Handelsman L., Cochrane K.J., Aronson M.J., Ness R., Rubinstein K.J., Kanof P.D. Two new rating scales for opiate withdrawal. Am. J. Drug Alcohol Abuse. 13:1987;293-308.
10. Handelsman L., Limpitlaw L., Williams D., Schmeidler J., Paris P., Stimmel B. Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients. Drug Alcohol Depend. 39:1995;173-180.
11. Hoffman J.A., Caudill B.D., Koman J.J., Luckey J.W., Flynn P.M., Hubbard R.L. Comparative cocaine abuse treatment strategies: enhancing client retention and treatment exposure. J. Addict. Dis. 13:(4):1994;115-128.
12. Kampman, K.M., Volpicelli, J.R., Alterman, A.I., Cornish, J., Acosta, T., Luce, D., O'Brien, C.P., 1999. Amantadine and propranolol improve treatment outcome in patients with severe cocaine withdrawal symptoms. College on Problems of Drug Dependence, 61st Annual Meeting, Abstracts, p. 72.
13. Kampman K., Volpicelli J.R., Alterman A., Cornish J., Weinrieb R., Epperson L., Sparkman T., O'Brien C.P. Amantadine in the early treatment of cocaine dependence: a double-blind, placebo-controlled trial. Drug Alcohol Depend. 41:1996;25-33.
14. Kampman K.M., Volpicelli J.R., McGinnis D.E., Alterman A.I., Weinrieb R.M., D'Angelo L., Epperson L.E. Reliability and validity of the cocaine selective severity assessment. Addict. Behav. 23:1998;449-461.
15. King G.R., Joyner C., Ellinwood E.H. Continuous or intermittent cocaine administration: effects of amantadine treatment during withdrawal. Pharmacol. Biochem. Behav. 47:1994;451-457.
16. Kornhuber J., Weller M., Schoppmeyer K., Riederer P. Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J. Neural. Transm. Suppl. 43:1994;91-104.
17. Kosten T.R., Morgan C.M., Falcione J., Schottenfeld R.S. Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine. Arch. Gen. Psychiatry. 49:1992;894-898.
18. Kraemer H.C., Thiemann S. A strategy to use soft data effectively in randomized controlled clinical trials. J. Consult. Clin. Psychol. 57:1989;148-154.
19. Mizoguchi K., Yokoo H, Yoshida M., Tanaka T., Tanaka M. Amantadine increases the extracellular dopamine levels in the striatum by re-uptake inhibition and by N-methyl-D-aspartate antagonism. Brain Res. 662:1994;255-258.
20. Pérez de los Cobos J.C., López-Ibor J.J., Sopelana P., Castañeda M. Cocaine use and opioid withdrawal syndrome. Eur. Psychiatry. 6:1991;89-92.
21. Pérez de los Cobos J., Trujols J., Ribalta E., Casas M. Cocaine use immediately prior to entry in an inpatient heroin detoxification unit as a predictor of discharges against medical advice. Am. J. Drug Alcohol Abuse. 23:1997;267-279.
22. Rasmussen K. The role of the locus coeruleus and N-methyl-D-aspartic acid (NMDA) and AMPA receptors in opiate withdrawal. Neuropsychopharmacology. 13:1995;295-300.
23. Robbins S.J., Ehrman R.N., Childress A.R., O'Brien C.P. Using cue reactivity to screen medications for cocaine abuse: a test of amantadine hydrochloride. Addict. Behav. 17:1992;491-499.
24. Rosen M.I., McMahon T.J., Woods S.W., Pearsall H.R., Kosten T.R. A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal. Eur. J. Pharmacol. 307:1996;251-257.
25. Spielberger C.D., Gorsuch R.L., Lushere R.E. Manual for The State-Trait Anxiety Inventory. 1970;Consulting Psychologists Press, Palo Alto.
26. Spitzer R.L., Williams J.B.W. Structured Clinical Interview for DSM-III-R (SCID). 1987;New York State Psychiatric Institute, Biometrics Research, New York.
27. Tennant F.S., Sagherian A.A. Double-blind comparison of amantadine and bromocriptine for ambulatory withdrawal from cocaine dependence. Arch. Intern. Med. 147:1987;109-112.
28. Tennant F., Tarver A., Sagherian A., Loveland D.B. A placebo-controlled elimination study to identify potential treatment agents for cocaine detoxification. Am. J. Addict. 2:1993;299-308.
29. Weddington W.W., Brown B.S., Haertzen C.A., Hess J.M., Mahaffey J.R., Kolar A.F., Jaffe J.H. Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. Am. J. Drug Alcohol Abuse. 17:1991;137-152.
30. Wise R.A. The neurobiology of craving: implications for the understanding and treatment of addiction. J. Abnorm. Psychol. 97:1988;118-132.