A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal

European Journal of Pharmacology

Volumn 307, Issue 3, 1996, Pages 251-257

  Rosen, Marc I ^a   McMahon, Thomas J ^a   Woods, Scott W ^a   Pearsall, H Rowland ^a   Kosten, Thomas R ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Dextromethorphan; Excitatory amino acid; Naloxone; Opiate; Withdrawal

Indexed keywords

DEXTROMETHORPHAN; NALOXONE; OPIATE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ABUSE; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WITHDRAWAL SYNDROME;

EID: 0030568712     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00249-X     Document Type: Article

References (45)

1. Aghajanian, G.K., J.H. Kogan and B. Moghaddam, 1994, Opiate withdrawal increased glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Res. 636 (1), 126.
2. Annels, S.J., Y. Ellis and J.A. Davies, 1991, Non-opioid anti-tussives inhibit endogenous glutamate release from rabbit hippocampal slices, Brain Res. 564, 341.
3. Apland, J.P. and D.J. Braitman, 1990, Effects of non-opioid antitussives on epileptiform activity and NMDA responses in hippocampal and olfactory cortex slices, Brain Res. 529 (1-2), 277.
4. Aram, J.A., D. Martin, M. Tomczyk, S. Zeman, J. Millar, G. Pohler and G. Lodge, 1989, Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phenylcyclidine, sigma and dextromethorphan receptor ligands. J. Pharmacol. Exp. Ther. 248 (1), 320.
5. Choi, D.W., S. Peters and V. Viseskul, 1987, Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons, J. Pharmacol. Exp. Ther. 242(2), 713.
6. Cohen, J., 1988, Statistical Power Analysis for the Behavioral Sciences, 2nd edn. (Lawrence Erlbaum Associates, Hillsdale, NJ, USA).
7. Degwitz, R., 1964, Dextromethorphan (Romilar) als Rauschmittel, Nervenartz 35, 412; cited in S. Murray and T. Brewerton, 1993, Abuse of over-the-counter dextromethorphan by teenagers, South. Med. J. 86 (10), 151.
8. Degwitz, R., 1964, Dextromethorphan (Romilar) als Rauschmittel, Nervenartz 35, 412; cited in S. Murray and T. Brewerton, 1993, Abuse of over-the-counter dextromethorphan by teenagers, South. Med. J. 86 (10), 151.
9. Dodds, A. and E. Reval, 1967, Toxic psychosis due to dextromethorphan, Med. J. Austral. 2. 231.
10. Elliott, K., A. Hynansky and C.E. Inturrisi, 1994, Dextromethorphan attenuates and reverses analgesic tolerance to morphine. Pain 59 (3). 361.
11. Felch, L.J., M.E. DiMarino and K.C. Kirby, 1994. Comparison of statistical methods for analyzing repeated measures data. The College on Problems of Drug Dependence, Poster presented, Palm Beach, Florida.
12. Ferkany, J.W., S.A. Borosky, D.B. Clissold and M.J. Pontecorvo, 1988. Dextromethorphan inhibits NMDA-induced convulsions, Eur. J. Pharmacol. 151, 151.
13. Fischman, M.W., R.W. Foltin, G. Nestadt and G.D. Pearlson, 1990, Effects of desipramine maintenance on cocaine self-administered by humans. J. Pharmacol. Exp. Ther. 253, 760.
14. Fleming, P.M., 1986, Dependence on dextromethorphan hydrobromide, Br. Med. J. Clin. Res. Ed. 293 (6547), 597.
15. Foltin, R.W. and M.W. Fischman, 1992, Self-administration of cocaine by humans: choice between smoked and intravenous cocaine, J. Pharmacol. Exp. Ther. 261 (3), 841.
16. 3H]dextrorphan binding in rat brain is localized to a noncompetitive antagonist site of the activated N-methyl-D-aspartate receptor-cation channel, Mol. Pharmacol. 41 (1), 134.
17. Goodman, W.K., D.S. Charney, L.H. Price, S.W. Woods and G.R. Heninger, 1986, Ineffectiveness of clonidine in the treatment of the benzodiazepine withdrawal syndrome: report of three cases, Am. J. Psychiatry 143, 900.
18. Higgins, G.A., P. Nguyen and E.M. Sellers, 1992, The NMDA antagonist dizocilpine (MK801) attenuates motivational as well as somatic aspects of naloxone precipitated opioid withdrawal, Life Sci. 50, PL167.
19. Hildebrand, M., W. Seifert and A. Reichenberger, 1989, Determination of dextromethorphan metabolizer phenotype in healthy volunteers, Eur. J. Clin. Pharmacol. 36, 315.
20. Isbell, H. and H.F. Fraser, 1953, Actions and addiction liabilities of dromoran derivatives in man, J Pharmacol. Exp. Ther. 107, 524.
21. Jasinski, M.D., W.R. Martin and P.A. Mansky, 1971, Progress Report on the assessment of the antagonists nalbuphine and GPA-2087 for abuse potential and studies of the effects of dextromethorphan in man. College on the Problems of Drug Dependence, Vol. 1, 143.
22. Jasinski, D.R., J.S. Pevnick, S.C. Clark and J.D. Griffith, 1977, Therapeutic usefulness of propoxyphene napsylate in narcotic addiction, Arch. Gen. Psychiatry 34, 227.
23. Kamei, J., Y. Iwamoto, M. Misawa and Y. Kasuya, 1993, Effects of Rimcazole, a specific antagonist at sigma sites, on the anti-tussive effects of non-narcotic anti-tussive drugs, Eur. J. Pharmacol. 242, 209.
24. Klein, M. and J.M. Musacchio, 1989, High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents, J. Pharmacol. Exp. Ther. 251 (1), 207.
25. Kolesnikov, Y.A., C.G. Pick, G. Ciszewska and G.W. Pasternak, 1993, Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor, Proc. Natl. Acad. Sci. USA 90 (11), 5162.
26. Kolesnikov, Y.A., M.L. Maccechini and G.W. Pasternak, 1994, 1-Aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance, Life Sci. 55 (18), 1393.
27. Koyuncouglu, H. and B. Saydam, 1990, The treatment of heroin addicts with dextromethorphan: a double-blind comparison of dextromethorphan with chlorpromazine, Int. J. Clin. Pharmacol. Ther. Toxicol. 28 (14), 147.
28. Koyuncouglu, H., M. Gungor, H. Sagduyu and F. Aricioglu, 1990, Suppression by ketamine and dextromethorphan of precipitated abstinence syndrome in rats. Pharmacol. Biochem. Behav. 35, 829.
29. Krystal, J.H., C.J. McDougle, T.R. Kosten, L.H. Price, G.K. Aghajanian and D.S. Charney, 1992, Baclofen-assisted detoxification from opiates: a pilot study, J. Subst. Abuse Treatm. 9, 139.
30. Larrey, D., G. Babany, M. Tinel, E. Freneaux, G. Amouyal, F. Habersetzer, P. Letteron and D. Pessayre, 1989, Effect of liver disease on dextromethorphan oxidation capacity and phenotype: a study of 107 patients, Br. J. Clin. Pharmacol. 28 (3), 297.
31. McEvoy, G.K. (ed.), 1990, AHFS Drug Information 90. Bethesda, MD, American Society of Hospital Pharmacists.
32. McNair, D., M. Lorr and L.H. Droppleman, 1971, Profile of Mood States. Educational and Industrial Testing, San Diego.
33. Musacchio, J.M., M. Klein nnd L.J. Santiago, 1988, High affinity dextromethorphan binding sites in guinea pig brain: further characterization and allosteric interactions, J. Pharmacol. Exp. Ther. 247 (2), 424.
34. Rasmussen, K. and G.K. Aghajanian. 1989, Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis, Brain Res. 505, 346.
35. Rasmussen, K., J.H. Krystal and G.K. Aghajanian, 1991, Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration, Psychopharmacology 105, 508.
36. Rosen, M.I., T.J. McMahon, A. Margolin, T.S. Gill, S.W. Woods, H.R. Pearsall, M.J. Kreek and T.R. Kosten, 1995, Reliability of sequential naloxone challenge tests. Am. J. Drug Alcohol Abuse 21 (4), 453.
37. Steinberg, G.K., E.H. Lo, D.M. Kunis, G.A. Grant, A. Poljak and R. DeLaPaz, 1991, Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia, Neurosci. Let. 133 (2), 225.
38. Tiseo, P.J. and C.E. Inturrisi, 1993: Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614, J. Pharmacol. Exp. Ther. 264 (3), 1090.
39. Tiseo, P.J., J. Cheng, G.W. Pasternak and C.E. Inturrisi, 1994, Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes. J. Pharmacol. Exp. Ther. 268 (1), 195.
40. Tortella, F.C., M. Pellicano and N.H. Bowery, 1989, Dextromethorphan and neuromodulation: old drug coughs up new activities, Trends Pharmacol. Sci. 10, 501.
41. Tortella, F.C., L. Robles, J.M. Witkin and A.H. Newman, 1994, Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration, and side-effect profile, J. Pharmacol. Exp. Ther. 268 (2), 727.
42. Trujillo, K.A. and H. Akil, 1991, Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801, Science 251 (4989), 85.
43. Trujillo, K.A. and H. Akil, 1995, Excitatory amino acids and drugs of abuse: a role for N-methyl-D-aspartate receptors in drug tolerance, sensitization, and physical dependence, Drug Alcohol Depend. 38 (2), 139.
44. Wang, R.I., R.L. Wiesen, S. Lamid and B.L. Roh, 1974, Rating the presence and severity of opiate dependence, Clin. Pharmacol. Ther. 16 (4), 653.
45. Wu, D., S.V. Otton, B.A. Sproule, U. Busto, T. Inaba, W. Kalow and E.M. Sellers, 1993, Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone, Br. J. Clin. Pharmacol. 35 (1), 30.