Solid phase synthesis of 3-(5'-carboxypentyl)-5-substituted tetrahydro- 2H-1,3,5-thiadiazin-2-thione derivatives

Tetrahedron Letters

Volumn 41, Issue 5, 2000, Pages 613-616

  Pérez, Rolando ^a   Reyes, Osvaldo ^b   Suarez, Margarita ^a   Garay, Hilda E ^b   Cruz, Luis J ^b   Rodríguez, Hortensia ^a   Molero Vilchez, María D ^c   Ochoa, Carmen ^d  

^a UNIVERSITY OF HAVANA   (Cuba)

^b CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^c Serv RMN Ctro E   (Spain)

^d INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

Resins amino acids; Solid phase synthesis; Thiadiazin 2 thiones

Indexed keywords

AMINO ACID; DITHIOCARBAMIC ACID; FORMALDEHYDE; HEXANOIC ACID DERIVATIVE; POLYSTYRENE DERIVATIVE; THIADIAZINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 0342445422     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02167-X     Document Type: Article

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12. 2 and base before the next step of the synthesis in order to improve the yields and the purity of the final product.
13. 6, 75.47 MHz): δ 190.2 (C1), 174.4 (C8), 40.5 (C3), 33.5 (C7), 25.7 (C4), 25.5 (C5) and 24.1 (C6).
14. 2 (362.50) C, 49.70; H, 7.23; N, 7.73. Found: C, 49.82; H, 7.35; N, 7.81.