Regular exercise enhances blood pressure lowering effect of acetylcholine by increased contribution of nitric oxide

Acta Physiologica Hungarica

Volumn 87, Issue 2, 2000, Pages 127-138

  Dörnyei, Gabriella ^a   Monos, Emil ^a   Kaley, G ^b   Koller, A ^a,b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Exercise; L NNA; Nitric oxide; Peripheral resistance; Rats; Sodium nitroprusside

Indexed keywords

ACETYLCHOLINE; ENDOTHELIUM DERIVED RELAXING FACTOR; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTERY ENDOTHELIUM; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EXERCISE; EXERCISE TOLERANCE; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PERIPHERAL CIRCULATION; RAT; SHORT COURSE THERAPY; TREADMILL; TREATMENT OUTCOME;

ACETYLCHOLINE; ANIMALS; BLOOD PRESSURE; BODY WEIGHT; ENZYME INHIBITORS; HEART RATE; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITROARGININE; NITROPRUSSIDE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 0342420693     PISSN: 0231424X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Armstrong, R. B., Laughlin, M. H.: Exercise blood flow patterns within and among rat muscles after training. Am. J. Physiol. 246 (Heart Circ. Physiol. 15), H59-68 (1984).
2. Bank, A. J., Shammas, R. A., Mullen, K., Chuang, P. P.: Effects of short-term forearm exercise training on resistance vessel endothelial function in normal subjects and patients with heart failure. J. Card. Fail. 4, 193-201 (1998).
3. Bloomqvist, C. G., Saltin, B.: Cardiovascular adaptations to physical training. Ann. Rev. Physiol. 45, 988-992 (1983).
4. Chen, Y., Collins, H., DiCarlo, Se.: Daily exercise enhances acetylcholine-induced dilation in mesenteric and hind limb vasculature of hypertensive rats. Clin. Exp. Hypertens. 21, 353-376 (1999).
5. Delp, M. D., McAllister, R. M., Laughlin, M. H.: Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J. Appl. Physiol. 75, 1354-1363 (1993).
6. Delp, M. D., Laughlin, M. H.: Regulation of skeletal muscle perfusion during exercise. Acta Physiol. Scand. 162, 411-419 (1998).
7. Dudley, G. A., Abraham, W. M., Terjung, R. L.: Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. J. Appl. Physiol. Respirat. Environ. Exercise Physiol. 53, 844-850 (1982).
8. 2 to acetylcholine in skeletal muscle venules. Am. J. Physiol. 272 (Heart Circ. Physiol. 41), H2541-2546 (1997).
9. Furchgott, R. F., Zawadzki, J. V.: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288, 373-376 (1980).
10. G-nitro-L-arginine methyl ester. Br. J. Parmacol. 100, 632-639 (1990).
11. G-nitro-L-arginine methyl ester in conscious, unrestrained rats. J. Cardiovascular Pharmacology 17(Suppl. 3), S173-S181 (1991).
12. Goreham, C., Green, H. J., Ball-Burnett, M., Ranney, D.: High-resistance training and muscle metabolism during prolonged exercise. Am. J. Physiol. 276, E489-496 (1999).
13. Huonker, M., Halle, M., Keul, J.: Structural and functional adaptation of the cardiovascular system by training. Int. J. Sports Med. 17, S164-172 (1996).
14. Katz, S. D., Yuen, J., Bijou, R., LeJemtel, T. H.: Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure. J. Appl. Physiol. 82, 1488-1492 (1997).
15. Kaley, G., Koller, A., Rodenburg, J. M., Messina, E. J., Wolin, M. S.: Regulation of arteriolar tone and responses via L-arginine pathway in skeletal muscle. Am. J. Physiol. 262 (Heart Circ. Physiol. 31), H987-H992 (1992).
16. Kiens, B.: Training and fatty acid metabolism. Adv. Exp. Med. Biol. 441, 229-238 (1998).
17. Kingwell, B. A., Tran, B., Cameron, J. D., Jennings, G. L., Dart, A. M.: Enhanced vasodilation to acetylcholine in athletes is associated with lower plasma cholesterol. Am. J. Physiol. 270, H2008-2013 (1996).
18. Koller, A., Kaley, G.: Endothelial regulation of wall shear stress and blood flow in skeletal muscle microcirculation. Am. J. Physiol. 260 (Heart Circ. Physiol. 29), H862-H868 (1991).
19. Koller, A., Seyedi, N., Gerritsen, M. E., Kaley, G.: EDRF released from microvascular endothelial cells dilates arterioles in vivo. Am. J. Physiol. 261 (Heart Circ. Physiol. 30), H128-H133 (1991).
20. Koller, A., Sun, D., Huang, A., Kaley, G.: Corelease of nitric oxide and prostaglandins to flow dilates rat gracilis muscle arterioles. Am. J. Physiol. 266 (Heart Circ. Physiol. 35), H326-H332 (1994).
21. Lash, J. M.: Regulation of skeletal muscle blood flow during contractions. Proc. Soc. Exp. Biol. Med. 211, 218-235 (1996).
22. Lash, J. M., Bohlen, H. G.: Time- and order-dependent changes in functional and NO-mediated dilation during exercise training. J. Appl. Physiol. 82, 460-468 (1997).
23. Lash, J. M., Bohlen, H. G.: Functional adaptations of rat skeletal muscle arterioles to aerobic exercise training. J. Appl. Physiol. 72, 2052-2062 (1992) 31.
24. Laughlin, M. H., McAllister, R. M., Jasperse, J. L., Crader, S. E., Williams, D. A., Huxley, V. H.: Endothelium-medicated control of the coronary circulation: Exercise training-induced vascular adaptations. Sports. Med. 22, 228-250 (1996).
25. Laughlin, M. H., Oltman, C. L., Bowles, D. K..: Exercise training-induced adaptations in the coronary circulation. Med. Sci. Sports Exerc. 30, 352-360 (1998).
26. Miller, V. M., Vanhoutte, P. M.: Enhanced release of endothelium-derived relaxing factor by chronic increases in blood flow. Am. J. Physiol. 255 (Heart Circ. Physiol.), H446-H451 (1988).
27. Monos, E., Contney, S., Cowley, A. W. Jr., Stekiel, W. J.: Effect of long-term tilt on mechanical electrical properties of rat saphenous vein. Am. J. Physiol. 256, H1185-1191 (1989).
28. Nadaud, S., Philippe, M., Arnal, J. F., Michel, J. B., Soubrier, F.: Sustained increase in aortic endothelial nitric oxide synthase expression in vivo in a model of chronic high blood flow. Circ. Res. 79, 857-863 (1996).
29. Parker, J. L., Mattox, M. L., Laughlin, M. H.: Contractile responsiveness of coronary arteries from exercise-trained rats. J. Appl. Physiol. 83, 434-443 (1997).
30. Saltin, B., Radegran, G., Koskolou, M. D., Roach, R. C.: Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol. Scand. 162, 421-436 (1998).
31. Scheuer, J., Tipton, C. M.: Cardiovascular adaptations to training. Annu. Rev. Physiol. 39, 221-231 (1977).
32. Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J., Hintze, T. H.: Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74, 349-353 (1994).
33. Sun, D., Huang, A., Koller, A., Kaley, G.: Short term daily exercise activity enhances endothelial nitric oxide synthesis in skeletal muscle arterioles of rats. J. Appl. Physiol. 76, 2241-2247 (1994).
34. Sun, D., Messina, E. J., Koller, A., Wolin, M. S., Kaley, G.: Endothelium dependent dilation to L-arginine in isolated rat skeletal muscle arterioles. Am. J. Physiol. 262 (Heart Circ. Physiol. 32), H1486-H1491 (1992).
35. Suzuki, J., Gao, M., Batra, S., Koyama, T.: Effects of treadmill training on the arteriolar and venular portions of capillary in soleus muscle of young and middle-aged rats. Acta Physiol. Scand. 159, 113-121 (1997).
36. Tulis, D. A., Unthank, J. L., Prewitt, R. L.: Flow-induced arterial remodeling in rat mesenteric vasculature. Am. J. Physiol. 274, H874-882 (1998).
37. Varin, R., Mulder, P., Richard, V., Tamion, F., Devaux, C., Henry, J. P., Lallemand, F., Lerebours, G., Thuillez, C.: Exercise improves flow-mediated vasodilatation of skeletal muscle arteries in rats with chronic heart failure. Role of nitric oxide, prostanoids and oxidant stress. Circulation. 99, 2951-2957 (1999).
38. Wang, J., Wolin, M. S., Hintze, T. H.: Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ. Res. 73, 829-838 (1993).