Usefulness of the I/D angiotensin-converting enzyme genotype for detecting the risk of left ventricular hypertrophy in pharmacologically treated hypertensive men

Journal of Human Hypertension

Volumn 14, Issue 5, 2000, Pages 327-331

  López Contreras, Joaquín ^a,b   Blanco Vaca, F ^a   Borras X ^a   Carreras, F ^a   Pons Llado G ^a   Gallego, F ^a   Sole M J ^a   Cirera, S ^a   Benet, M T ^a   Negredo, E ^a   Roca Cusachs, A ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Angiotensin converting enzyme; Essential hypertension; Left ventricular hypertrophy; Polymorphism

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLONIDINE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; GENE; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENOTYPE; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; RISK ASSESSMENT;

EID: 0342369502     PISSN: 09509240     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jhh.1001005     Document Type: Article

References (34)

1. Devereux RB, Roman MJ. Hypertensive cardiac hypertrophy: Pathophysiologic and clinical characteristics. In: Laragh JH, Brenner BM (eds). Hypertension; Pathophysiology, Diagnosis and Treatment. 2nd edn. Raven Press: New York, 1995, pp 409-432.
2. Rigat B et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
3. Cambien F et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359: 641-644.
4. Tiret L et al. Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction. Lancet 1993; 341: 991-992.
5. Ohishi M et al. A potent genetic risk factor for restenosis. Nature Genetics 1993; 5: 324-325.
6. Raynolds MV et al. Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy. Lancet 1993; 342: 1073-1075.
7. Nakai K et al. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk of CAD in the Japanese. Circulation 1994; 90: 2199-2202.
8. Cambien F et al. Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction. Circulation 1994; 90: 669-676.
9. Ruiz J et al. Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin dependent diabetes mellitus. Proc Natl Acad Sci USA 1994; 91: 3662-3665.
10. Oike Y et al. Angiotensin converting enzyme as a genetic risk factor for coronary artery spasm. Implication in the pathogenesis of myocardial infarction. J Clin Invest 1995; 96: 2975-2979.
11. Kario K et al. Hypertensive nephropathy and the gene for angiotensin-converting enzyme. Arterioscler Thromb Vasc Biol 1997; 17: 252-256.
12. Fernandez-Llama P et al. Angiotensin coverting enzyme gene I/D polymorphism in essential hypertension and nephroangiosclerosis. Kidney Int 1998; 53: 1743-1747.
13. O'Donnell CJ et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998; 97: 1766-1772.
14. Kiema TR et al. Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure. Hypertension 1996; 28: 1070-1075.
15. Barley J et al. Angiotensin converting enzyme gene I/D polymorphism, blood pressure and the renin-angiotensin system in Caucasian and Afro-American peoples. J Hum Hypertens 1996; 10: 31-35.
16. Hingorani AD et al. Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition. J Hypertens 1995; 13: 1602-1609.
17. Mandorf UF et al. Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension. Am J Hypertens 1998; 11: 174-183.
18. Dieguez-Lucena JL et al. Angiotensin I-converting enzyme genotypes and angiotensin II receptors. Response to therapy. Hypertension 1996; 28: 98-103.
19. Dudley C et al. Prediction of patient responses to anti-hypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes. J Hypertens 1996; 14: 259-262.
20. Schunkert H et al. Association between deletion polymorphism of the angiotensin-converting enzyme gene and left ventricular hypertrophy. N Engl J Med 1994; 330: 1634-1638.
21. Iwai N, Ohmichi N, Nakamura Y, Kinoshita M. DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophy. Circulation 1994; 90: 2622-2628.
22. Gharavi AG et al. Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension. Am J Cardiol 1996; 77: 1315-1319.
23. Clarkson PB et al. Influence of the angiotensin converting enzyme I/D gene polymorphisms on left ventricular diastolic filling in patients with essential hypertension. J Hypertens 1997; 15: 995-1000.
24. Perticone F et al. Deletion polymorphism of angiotensin-converting enzyme and left ventricular hypertrophy in southern Italian patients. J Am Coll Cardiol 1997; 29: 365-369.
25. Prasad N et al. The relationship between blood pressure and left ventricular mass in essential hypertension is observed only in the presence of the angiotensin-converting enzyme gene deletion allele. QJM 1994; 87: 659-662.
26. Lindpainter K et al. Absence of association or genetic linkage between the angiotensin-converting enzyme gene and left ventricular mass. N Engl J Med 1996; 334: 1023-1028.
27. Mayet J et al. Left ventricular hypertrophy, blood pressure and ACE genotype in untreated hypertension. J Hum Hypertens 1997; 11: 595-597.
28. West MJ et al. Renin and angiotensin-converting enzyme genotype in patients with essential hypertension and left ventricular hypertrophy. Clin Exp Pharmacol Physiol 1994; 21: 207-210.
29. Beige J et al. Genetic variants of the renin-angiotensin system and ambulatory blood pressure in essential hypertension. J Hypertens 1997; 15: 503-508.
30. Kupari M et al. Left ventricular size, mass, and function in relation to angiotensin-converting enzyme gene polymorphism in humans. Am J Physiol 1994; 267(3 pt 2): H1107-H1111.
31. Sasaki M et al. Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies. J Hypertens 1996; 14: 1403-1408.
32. The Fifth Report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure. Arch Intern Med 1993; 153: 154-183.
33. Lindpainter K et al. A prospective evaluation of angiotensin-converting enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 1995; 15: 1280-1286.
34. Devereux RB, Roman MJ. Evaluation of cardiac and vascular structure and function by echocardiography and other noninvasive techniques. In: Laragh JH, Brenner BM (eds). Hypertension: Pathophysiology, Diagnosis and Treatment. 2nd edn. Raven Press: New York, 1995, pp 1969-1985.