MPTP decreases MT-I mRNA in mouse striatum

Neurochemical Research

Volumn 25, Issue 4, 2000, Pages 503-509

  Rojas, Patricia ^a   Rojas Castañeda, Julio ^b   Vigueras, Rosa María ^b   Habeebu, Sultan S M ^c   Rojas, Carolina ^b   Ríos, Camilo ^a   Ebadi, Manuchair ^d  

^a NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^b INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Metallothionein I; MPTP; MT I mRNA; Oxidative stress; Parkinson's disease; Striatum

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; MESSENGER RNA; METALLOTHIONEIN; SCAVENGER;

ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GLIA CELL; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; AUTORADIOGRAPHY; BRAIN; CEREBRAL CORTEX; CORPUS STRIATUM; FREE RADICAL SCAVENGERS; GENE EXPRESSION; IN SITU HYBRIDIZATION; LIVER; MALE; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MPTP POISONING; NEURONS; ORGAN SPECIFICITY; OXIDATIVE STRESS; RATS; RNA, MESSENGER; ZINC SULFATE;

ANIMALIA; PRIMATES;

EID: 0342313713     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007564126478     Document Type: Article

References (35)

1. Gerlach, M., Riederer, P., Przuntek, H., and Youdim, M. B. H. 1991. MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease. Eur. J. Pharmacol. Mol. Pharmacol. 208:273-286.
2. Heikkila, R. E., Cabbat, F. S., Manzino, L., and Duvoisin, R. C. 1984. Effects of MPTP on nigrostriatal dopamine in mice. Neuropharmacol. 23:711-713.
3. Chiba, K., Trevor, A., and Castagnoli, N. 1984. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem. Biophys. Res. Commun. 120:574-578.
4. +, a metabolite of MPTP by brain synaptosomes. Biochem. Biophys. Res. Commun. 128:1228-1232.
5. +, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase. Arch. Biochem. Biophys. 259:645-649.
6. Adams, J. D., and Odunze, I. N. 1991. Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. Could oxidative stress be involved in the brain? Biochem. Pharmacol. 41:1099-1105.
7. + administration to mice. Pharmacol. Toxicol. 72:364-368.
8. Ríos, C., Alvarez-Vega, R., and Rojas, P. 1995. Depletion of copper and manganese in brain after MPTP treatment of mice. Pharmacol. Toxicol. 76:348-352.
9. Kagi, J. H. R., 1993. Evolution, structure and chemical activity of class I metallothionein: an overview. Pages 29-56, in Suzuki, K. T., Imura, N. and Kimura, M. (eds.). Metallothionein III: Biological Roles and Medical Implications, Birkhauser Verlag, Berlin.
10. Masters, B. A., Quaife, C. J., Erickson, J. C., Kelly, E. J., Froelick, G. J., Zambrowicz, B. P., Brinster, R. L., and Palmiter, R. D. 1994. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles. J. Neurosci., 14:5844-5857.
11. Quaife, C. J., Findley, S.D., Erickson, J. C., Forelick, G. J., Kelly, E. J., Zambrowicz, B. P., and Palmiter, R. D. 1994. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry. 33:7250-7259.
12. Lazo, J. S. and Pitt, B. R. 1995. Metallothioneins and cell death by anticancer drugs. Annu. Rev. Pharmacol. Toxicol. 35:635-653.
13. Ebadi, M. 1991. Metallothionein and other zinc binding proteins in brain. Meth. Enzymol. 205:363-387.
14. Ebadi, M., Iversen, P. L., Hao, R., Cerutis, D. R., Rojas, P., Happe, H. K., Murrin, L. C., and Pfeiffer, R. F. 1995. Expression and regulation of brain metallothionein. Neurochem. Int. 27:1-22.
15. Hidalgo, J., Gasull, T., Giralt, M., and Armario, A. 1994. Brain metallothionein in stress. Biol. Signals. 3:198-210.
16. Hidalgo, J., Campmany, L., Borras, M., Garvey, J. S., and Armario, A. 1988. Metallothionein response to stress in rats: role in free radicals scavenging. Am. J. Physiol. 255, E518-E524.
17. Lazo, J. S., Kondo, Y., Dellapiazza, D., Michalska, A. E., Choo, K. H., and Pitt, B. R. 1995. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 270:5506-5510.
18. Sato, M., and Bremer, I. 1993.Oxygen free radicals and metallothionein. Free Rad. Biol. Med. 14:325-337.
19. Ebadi, M., Leuschen, M. P., ElRefaey, H., Hamada, M., and Rojas, P. 1996. The antioxidant properties of zinc and metallothionein. Neurochem. Int. 29:159-166.
20. Choudhuri, S., McKim, J. M., and Klaassen, C. 1993. Differential expression of metallothionein gene in liver and brain of mice and rats. Toxicol. Appl. Pharmacol. 119:1-10.
21. Rojas, P., and Ríos, C. 1997. Metallothionein inducers protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice. Neurochem. Res. 22(1):17-22.
22. Rojas, P., Hidalgo, J., Ebadi, M., and Ríos, C. 2000. Changes of metallothionein I + II proteins in the brain after 1-methyl -4-phenylpyridinium administration in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 24:143-154.
23. Young, J. K. (1994). Glial metallothionein. Biol. Signals. 3: 169-175.
24. Rojas, P., Cerutis, D. R., Happe, H. K., Murrin, L. C., Hao, R., Pfeiffer, R. F., and Ebadi, M. 1996. 6-hydroxydopamine-mediated induction of rat brain metallothionein 1 mRNA. Neurotoxicol. 17(2):323-334.
25. Andersen, R. D., Birren, B. W., Ganz, T., Piletz, J. E., and Herschman, H. R. 1983. Molecular cloning of the rat metallothionein I (mT1) mRNA sequence. DNA. 2:15-22.
26. Murrin, L. C. 1980. Receptor binding, techniques and light microscopic autoradiography. Pages 241-256, in Bylund, D. B. (ed), Receptor Binding Techniques. Bethesda, MD: Society for Neuro science.
27. Uhl, G. R. 1986. In situ Hybridization in Brain. Plenum Press. New York.
28. Scheuhammer, A. M., and Cherian, G. M. 1986. Quantification of metallothionein by silver-saturation method. Toxicol. Appl. Pharmacol. 82:417-425.
29. Welz, B. 1976. Atomic spectroscopy. Verlag-Chemie, Weinheim, New York.
30. Kagi, J. H. R., and Kojima, Y. 1987. Metallothionein II and Other Low Molecular Weight Metal Binding Proteins, Pages 1-755. Birkhauser Verlag, Basel.
31. Suzuki, K. T., Imura, N., and Kimura, M: 1993. Metallothionein III, Biological Roles and Medical Implications. Pages 1-477, Birkhauser Verlag, Basel.
32. Halliwell, B., and Gutteridge, J. M. C. 1985. Free radicals in biology and medicine, Oxford Claredon.
33. Ferraro, T. N., Golden, G. T., DeMattei, M., Hare, T. A., and Fariello, R. G. 1986. Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on glutathione in the extrapyramidal system of the mouse. Neuropharmacol. 25:1071-1074.
34. Jiménez, I., Gotteland, M., Zarzuelo, A., Uauy, R., and Speisky, H. 1997. Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals. Toxicol. 120: 37-46.
35. Thiffault, C., Aumont, T., Quirion, R., and Poirier, J. 1995. Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain. J. Neurochem. 65(6): 2725-2733.