Study on the Total Synthesis of Et 743 and its Analogues: Synthesis of a Tricyclic Intermediate and its 11-Epimer

Chinese Chemical Letters

Volumn 14, Issue 10, 2003, Pages 996-998

  Tang, Ye Feng ^a   Liu, Zhan Zhu ^a   Chen, Shi Zhi ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Et 743; Stereochemistry; Synthesis; Tricyclic compound

Indexed keywords

DRUG DERIVATIVE; ECTEINASCIDIN 743;

ARTICLE; DRUG SYNTHESIS; EPIMER; ISOMER; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; STEREOCHEMISTRY;

EID: 0242720628     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Y. F. Tang, Z. Z. Liu, S. Z. Chen, Chin. Chem. Lett., in press.
2. E. J. Corey, et al. J. Am. Chem. Soc., 1996, 118, 9202.
3. E. J. Martinez, et al. Proc. Nat. Acad. Sci. USA, 1999, 96, 3496.
4. 3O), 4.23 (dd, 1H, J=3.0, 7.8 Hz, H-13), 5.26 (q, 1H, J=6.9 Hz, H-1), 6.18 (brs, 1H, NH), 6.69-6.65 (m, 5H, 5xArH); FABMS (m/z): 441 (M+H).
5. M. P. Paradisi, et al. J. Hereocyclic Chem., 1990, 27, 1661.