Noradrenaline-Induced Contraction Mediated by Endothelial COX-1 Metabolites in the Rat Coronary Artery

Journal of Cardiovascular Pharmacology

Volumn 42, Issue SUPPL. 1, 2003, Pages

  Wang, Aimin ^a   Nishihashi, Tsuyoshi ^a   Murakami, Shizuka ^a   Trandafir, Cristina C ^a   Ji, Xu ^a   Shimizu, Yoshiharu ^b   Kurahashi, Kazuyoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY   (Japan)

Author keywords

Endothelium derived COX 1 metabolites; NAd induced contraction; Rat coronary artery; Reactive oxygen species

Indexed keywords

ARACHIDONIC ACID; CATALASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DOMITROBAN; FLURBIPROFEN; N(G) NITROARGININE METHYL ESTER; NIMESULIDE; NORADRENALIN; OZAGREL; SAPONIN; SUPEROXIDE DISMUTASE; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE INHIBITOR;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFECT; DRUG MECHANISM; ENZYME ANALYSIS; ENZYME LOCALIZATION; MALE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

EID: 0242718432     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200312001-00010     Document Type: Conference Paper

References (12)

1. 2-Adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats. J Pharmacol Exp Ther 1996;278:1235-43.
2. 1-Adrenoceptor stimulation induces nitric oxide release in rat pulmonary arteries. J Vasc Res 1999;36:79-81.
3. Usui H, Shirahase H, Kurahashi K, et al. Endothelium-dependent vasocontraction in response to noradrenaline in the canine cerebral artery. Jpn J Pharmacol 1987;44:228-31.
4. Saïag B, Hillarie-Buys D, Chapal J, et al. Study of the mechanisms involved in adenosine-5′-O-(2-thiodiphosphate) induced relaxation of rat thoracic aorta and pancreatic vascular bed. Br J Pharmacol 1996;118:804-10.
5. Abrahamsson T, Brandt U, Marklund SL, et al. Vascular bound recombinant extracellular superoxide dismutase type C protects against the detrimental effects of superoxide radicals on endothelium-dependent arterial relaxation. Circ Res 1992;70:264-71.
6. Marin J, Roddrigez-Martinez MA. Nitric oxide, oxygen-derived free radicals and vascular endothelium. J Auton Pharmacol 1995;115:993-1000.
7. Miralpeix M, Camacho M, Lopez-Belmonte J, et al. Selective induction of cyclo-oxygenase-2 activity in the permanent human endothelial cell line HUVEC-EC-C: biochemical and pharmacological characterization. Br J Pharmacol 1997;121:171-80.
8. Riendeau D, Percival MD, Boyce S, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. BrJ Pharmacol 1997;121:105-17.
9. Emert L, Emert M, Althoff A, et al. Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs. J Pharmacol Exp Ther 1998;286:1309-14.
10. Masferrer J, Zwefel BS, Manning PT, et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA 1994;91:3228-32.
11. Iizuha K, Akahane K, Momose D, et al. Highly selective inhibitors of thromboxane synthetase. I. Imidazole derivatives. J Med Chem 1981;24:1139-48.
12. Narisada M, Ohtani M, Watanabe F, et al. Synthesis and in vivo activity of various derivatives of a novel thromboxane receptor antagonist, (±)-(5Z)-7-[3-endo-[(phenylsulfonyl)aminolbicyclo-[2,2,1]hept-2-exoyl] heptenoic acid. J Med Chem 1988;31:1847-54.