Is Hypogonadism a Risk Factor for Sexual Dysfunction?

Journal of Andrology

Volumn 24, Issue 6 SUPPL., 2003, Pages

  Ojumu, Akinlolu ^b   Dobs, Adrian S ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PROSTAGLANDIN E1; SILDENAFIL; TESTOSTERONE; UNCLASSIFIED DRUG;

ACNE; ADULT; AGED; ALGORITHM; ANIMAL MODEL; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DYSLIPIDEMIA; ERECTILE DYSFUNCTION; FOLLOW UP; GYNECOMASTIA; HORMONE SUBSTITUTION; HUMAN; HYPOGONADISM; IMPOTENCE; MAJOR CLINICAL STUDY; MALE; MIGRAINE; NONHUMAN; POLYCYTHEMIA; PRIORITY JOURNAL; PROSTATE DISEASE; RAT; RISK FACTOR; SIDE EFFECT; SLEEP APNEA SYNDROME; TESTOSTERONE BLOOD LEVEL; TREATMENT CONTRAINDICATION; TREATMENT INDICATION; TREATMENT PLANNING;

EID: 0242709988     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1939-4640.2003.tb02746.x     Document Type: Conference Paper

References (45)

1. Ansong KS, Punwaney RB. An assessment of the clinical relevance of serum testosterone level determination in the evaluation of men with low sexual drive. J Urol. 1999;162:719-721.
2. Arver S, Dobs, AS, Meikle AW, et al. Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J Urol. 1996;155:1604-1608.
3. Aversa A, Isidori AM, De Martino MU, et al. Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction. Clin Endorinol (Oxf). 2000;53:517-522.
4. Baker HW, Burger HG, Hudson B. Changes in the pituitary-testicular axis with age. Clinical and experimental studies. In: De Krester BM, Burger HG, Hudson B, eds. The Pituitary and Testis. Monographs on Endocrinology 25. Berlin-Hamburg-New York: Springer; 1983:71-82.
5. Basaria S, Dobs AS. Risks versus benefits of testosterone therapy in elderly men. Drugs Aging. 1999;15:131-142.
6. Behre HM, Bohmeyer J, Nieschlag E. Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age matched normal controls. Clin Endocrinol (Oxf). 1994;40:341-349.
7. Bhasin S, Storer TW, Asbel-Sethi N, et al. Effects of testosterone replacement with a nongenital, transdermal system, androderm, in human immunodeficiency virus-infected men with low testosterone levels. 1998;83:3155-3162.
8. Burris AS, Banks SM, Carter CS, Davidson JM, Sherins RJ. A long-term, prospective study of the physiologic and behavior effects of hormone replacement in untreated hypogonadal men. J Androl. 1992;13:297-304.
9. Carani C, Scuteri A, Marrama P, Bancoft J. The effects of testosterone administration and visual erotic stimuli on nocturnal penile tumescence in normal men. Horm Behav. 1990;24:435-441.
10. Chamness SL, Ricker DD, Crone JK, et al. The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil Steril. 1995;63:1101-1107.
11. Cohan P, Korenman SG. Commentary: erectile dysfunction. J Clin Endocrinol Metab. 2001;86:6.
12. Cunningham GR, Hirshkowitz M, Koreman SG, et al. Testosterone replacement therapy and sleep-related erections in hypogonadal men. J Clin Endocrinol Metab. 1990;70:792-797.
13. Davidson JM, Camargo CA, Smith ER. Effects of androgen on sexual behavior in hypogonadal men. J Clin Endocrinol Metab. 1979;48:955-958.
14. Davidson JM, Kwan M, Greenleaf WJ. Hormonal replacement and sexuality in men. J Clin Endocrinol Metab. 1982;11:599-623.
15. Dobs AS, Wayne M, Arver S, et al. Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. J Clin Endrocrinol Metab. 1999;84:3469-3478.
16. Fahmy AK, Mitra S, Blacklock AR, Desai KM. Is the measurement of serum testosterone routinely indicated in men with erectile dysfunction? BJU Int. 1999;84:482-484.
17. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994;151:54-61.
18. Harman SM, Metter EJ, Tobin JD, et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab. 2001;86:724-731.
19. NIH. NIH Consensus Statements: 91. Impotence. 1992 Dec 7-9;10(4):1-31. Available at: http://consensus.nih.gov/cons/091/091/_statement.htm.
20. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB. Incidence of erectile dysfunction in men 40-69 years old: longitudinal results from the Massachusetts Male Aging Study. J Urol. 2000;163:460-463.
21. Johnson AR III, Jarow JP. Is routine endocrine testing of impotent men necessary? J Urol. 1992;147:1542-1544.
22. Klee GG, Heser DW. Techniques to measure testosterone in the elderly. Mayo Clin Proc. 2000;75(suppl):S19-S25.
23. Korenman SG, Morley JE, Modradian AD, Davis SS, Kaiser FE, Silver AJ, Viosca SP, Garza D. Secondary hypogonadism in older men: its relation to impotence. J Clin Endocrinol Metab. 1990;71:963-969.
24. Kubin M, Wagner G, Fugyl-Meyer AR. Epidemiology of erectile dysfunction. Int J Impot Res. 2003;15:63-71.
25. Kwan M, Greenleaf WJ, Mann J, Crapo L, Davidson JM. The nature of androgen action on male sexuality: a combined laboratory self-report study on hypogonadal men. J Clin Endrocrinol Metab. 1983;57:557-562.
26. Lehman K, Schopke W, Brutsch HP, Hauri D. Which hormone determinations are necessary in the initial assessment of ED? Schweiz Rundsch Med Prax. 1994;83:1030-1033.
27. Maatman TJ, Montague DK. Routine endocrine screening in impotence. Urology. 1986;27:499-502.
28. Manieri C, Di Bisceglie C, Tagliabue M, Fornengo R, Zumpano E. Hormonal control of sexual behavior in males and endocrinologic causes of sexual dysfunction. Minerva Endocrinol. 1997;22:37-43.
29. McClure RD, Oses R, Ernest ML. Hypogonadal impotence treated with testosterone. Urology. 1991;37:224-228.
30. McNicholas TA, Dean JD, Mulder H, et al. A novel testosterone gel formulation normalizes androgen levels in hypogonadal men with improvements in body composition and sexual function. BJU Int. 2003;91:69-74.
31. Mills TM, Lewis RW. The role of androgens in the erectile response: a 1999 perspective. Mol Urol. 1999;3:75-86.
32. Monga M, Kostelec M, Kamarei M. Patient satisfaction with testosterone supplementation for the treatment of erectile dysfunction. Arch Androl. 2002;48:433-442.
33. Morales A, Heaton JP. Hormonal erectile dysfunction. Evaluation and management. Urol Clin North Am. 2001;28:279-288.
34. Nehra A. Treatment of endocrinology male sexual dysfunction. Mayo Clin Proc. 2000;75(suppl):S40-S45.
35. O'Carroll R, Bancroft J. Testosterone therapy for low sexual interest and erectile dysfunction in men: a controlled study. Br J Psychiatry. 1984;145:146-151.
36. Reilly CM, Zamorano P, Stopper VS, Mills JM. Androgenic regulation of NO availability in a rat penile erection. J Androl. 1997;18:110-115.
37. Rhoden EL, Teloken C, Sogari CA. The relationship of serum testosterone to erectile function in normal aging men. J Urol. 2002;167:1745-1748.
38. Salmimies P, Kockott G, Pirke KM, Vogt HJ, Schill WB. Effects of testosterone replacement on sexual behavior in hypogonadal men. Arch Sex Behav. 1982;11:345-353.
39. Schatzl G, Madersbacher S, Temml C, et al. Serum androgen levels in men: impact on health status and age. Urology. 2003;61:629-633.
40. Schill WB. Fertility and sexual life of men after their forties and in older age. Asian J Androl. 2001;3:1-7.
41. Steidle C, Schwartz K, Jacoby T, et al. AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. J Clin Endrocrinol Metab. 2003;88:2673-2681.
42. Thomas AM. Diagnostic evaluation of erectile dysfunction. Am Fam Physician. 2000;61:95-104, 109-110.
43. Vermuelen A. Androgen replacement therapy in the aging male - a critical evaluation. J Clin Endocrinol Metab. 2001;86:2380-2390.
44. Wang C, Swerdloff RS, Iranmanesh A, et al. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J Clin Endrocrinol Metab. 2000;85:2839-2853.
45. Wespes E, Schulman CC. Male andropause: myth, reality, and treatment. Int J Impot Res. 2002;14(suppl 1):S93-S98.