Enzyme I of the phosphotransferase system: Induced-fit protonation of the reaction transition state by Cys-502

Biochemistry

Volumn 42, Issue 16, 2003, Pages 4744-4750

  García Alles, Luis Fernando ^a   Alfonso, Ignacio ^b   Erni, Bernhard ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF OVIEDO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; ELECTRON TRANSITIONS; ENZYME INHIBITION;

ELECTRON DISPERSION;

ENZYMES;

ENZYME INHIBITOR; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE;

ACID BASE BALANCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; ENZYME BINDING; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON TRANSPORT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CATALYSIS; CYSTEINE; DIMERIZATION; ENZYME INHIBITORS; ISOMERISM; KINETICS; MUTATION; OXALATES; PHOSPHOENOLPYRUVATE; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE SYSTEM; PHOSPHOTRANSFERASES (NITROGENOUS GROUP ACCEPTOR); PROTEIN CONFORMATION; PROTONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242684441     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034007f     Document Type: Article

References (43)

1. Postma, P. W., Lengeler, J. W., and Jacobson, G. R. (1996) in Escherichia coli and Salmonella: cellular and molecular biology (Neidhardt, F. C., et al., Eds.) pp 1149-1174, ASM Press, Washington, DC.
2. Lee, B. R., Lecchi, P., Pannell, L., Jaffe, H., and Peterkofsky, A. (1994) Arch. Biochem. Biophys. 312, 121-124.
3. LiCalsi, C., Crocenzi, T. S., Freire, E., and Roseman, S. (1991) J. Biol. Chem. 266, 19519-19527.
4. Alpert, C. A., Frank, R., Stueber, K., and Deutscher, J. H. (1985) Biochemistry 24, 959-964.
5. Garrett, D. S., Seok, Y. J., Peterkofsky, A., Clore, G. M., and Gronenborn. A. M. (1998) Protein Sci. 7, 789-793.
6. Weigel, N., Kukuruzinska, M. A., Nakazawa, A., and Waygood, E. B. R. S. (1982) J. Biol. Chem. 257, 14477-14491.
7. Liao, D. I., Silverton, E., Seok, Y. J., Lee, B. R., Peterkofsky, A., and Davies, D. R. (1996) Structure 4, 861-872.
8. Garrett, D. S., Seok, Y. J., Liao, D. I. Peterkofsky, A., Gronenborn, A. M., and Clore, G. M. (1997) Biochemistry 36, 2517-2530.
9. Garrett, D. S., Seok, Y. J., Peterkofsky, A., Clore, G. M., and Gronenborn, A. M. (1997) Biochemistry 36, 4393-4398.
10. Garrett, D. S., Seok, Y. J., Peterkofsky, A., Gronenborn, A. M., and Clore, G. M. (1999) Nat. Struct. Biol. 6, 166-173.
11. Herzberg, O., Chen, C. C., Kapadia, G., McGuire, M., Carroll, L. J., Noh, S. J., and Dunaway-Mariano, D. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 2652-2657.
12. Garcia-Alles, L. F., Flükiger, K., Hewel, J., Gutknecht, R., Siebold, C., Schürch, S., and Erni, B. (2002) J. Biol. Chem. 277, 6934-6942.
13. Seok, Y. J., Lee, B. R., Gazdar, C., Svenson, I., Yadla, N., and Peterkofsky, A. (1996) Biochemistry 35, 236-242.
14. Zhu, P. P., Szczepanowski, R. H., Nosworthy, N. J., Ginsburg, A., and Peterkofsky, A. (1999) Biochemistry 38, 15470-15479.
15. Seok, Y. J., Lee, B. R., Zhu, P. P., and Peterkofsky, A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 347-351.
16. Pocalyko, D. J., Carroll, L. J., Martin, B. M., Babbitt, P. C., and Dunaway-Mariano, D. (1990) Biochemistry 29, 10757-10765.
17. Weigel, N., Waygood, E. B., Kukuruzinska, M. A., and Nakazawa, A. R. (1982) J. Biol. Chem. 257, 14461-14469.
18. Waygood, E. B., and Steeves, T. (1980) Can. J. Biochem. 58, 40-48.
19. Hoving, H., Lolkema, J. S., and Robillard, G. T. (1981) Biochemistry 20, 87-93.
20. Seok, Y. J., Zhu, P. P., Koo, B. M., and Peterkofsky, A. (1998) Biochem. Biophys. Res. Commun. 250, 381-384.
21. Misset, O., Brouwer, M., and Robillard, G. T. (1980) Biochemistry 19, 883-890.
22. Han, M. K., Knutson, J. R., Roseman, S., and Brand, L. (1990) J. Biol. Chem. 265, 1996-2003.
23. Dimitrova, M. N., Szczepanowski, R. H., Ruvinov, S. B., Peterkofsky, A., and Ginsburg, A. (2002) Biochemistry 41, 906-913.
24. Chauvin, F., Brand, L., and Roseman, S. (1994) J. Biol. Chem. 269, 20263-20269.
25. Kukuruzinska, M. A., Turner, B. W., Ackers, G. K., and Roseman, S. (1984) J. Biol. Chem. 259, 11679-11681.
26. Chauvin, F., Brand, L., and Roseman, S. (1996) J. Biol. Chem. 269, 20270-20274.
27. Garcia-Alles, L. F., and Erni, B. (2002) Eur. J. Biochem. 269, 3226-3236.
28. Stubbe, J. A., and Kenyon, G. L. (1972) Biochemistry 11, 338-345.
29. Duffy, T. H., Saz, H. J., and Nowak, T. (1982) Biochemistry 21, 132-139.
30. Stolz, B., Huber, M., Markovic-Housley, Z., and Erni, B. (1993) J. Biol. Chem. 268, 27094-27099.
31. Hesterkamp, T., and Erni, B. (1999) J. Mol. Microbiol. Biotechnol. 1, 309-317.
32. Mao, Q., Schunk, T., Flükiger, K., and Erni, B. (1995) J. Biol. Chem. 270, 5258-5265.
33. Stewart, J. J. P, (1989) J. Comput. Chem. 10, 209-220.
34. Lias, S. G., Bartmess, J. E., Liebman, J. F., Holmes, J. L., Levin, R. D., and Maillard, W. G. (1988) J. Phys. Chem. Ref. Data Suppl. 17, 861.
35. Hoving, H., Nowak, T., and Robillard, G. T. (1983) Biochemistry 22, 2833-2838.
36. Saier, M. H., Schmidt, M. R., and Lin, P. (1980) J. Biol. Chem. 255, 8579-8584.
37. Hoving, H., ten Hoeve Duurkens, R., and Robillard, G. T. (1984) Biochemistry 23, 4335-4340.
38. Fersht, A. (1999) Structure and mechanism in protein science: a guide to enzyme catalysis and protein folding, W. H. Freeman, New York.
39. Hoving, H., Crysell, B., and Leadlay, P. F. (1985) Biochemistry 24, 6163-6169.
40. Seidel, H. M., and Knowles, J. R. (1994) Biochemistry 33, 5641-5646.
41. Reed, G. H., and Morgan, S. D. (1974) Biochemistry 13, 3537-3541.
42. Schonbrunn, E., Eschenburg, S., Krekel, F., Luger, K., and Amrhein, N. (2000) Biochemistry 39, 2164-2173.
43. Kuzmic, P. (1996) Anal. Biochem. 237, 260-273.