The Structure of the S127P Mutant of Cytochrome b5 Reductase that Causes Methemoglobinemia Shows the AMP Moiety of the Flavin Occupying the Substrate Binding Site

Biochemistry

Volumn 42, Issue 45, 2003, Pages 13145-13151

  Bewley, Maria C ^a,c   Davis, C Ainsley ^b   Marohnic, Christopher C ^b   Taormina, David ^a   Barber, Michael J ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENETIC ENGINEERING; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION KINETICS;

MUTATIONS;

ENZYMES;

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; CYTOCHROME B5 REDUCTASE; FLAVINE ADENINE NUCLEOTIDE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME STRUCTURE; KINETICS; METHEMOGLOBINEMIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT;

ADENOSINE MONOPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME-B(5) REDUCTASE; FLAVIN-ADENINE DINUCLEOTIDE; HUMANS; KINETICS; METHEMOGLOBINEMIA; MUTAGENESIS, SITE-DIRECTED; NAD; PROLINE; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SERINE; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY;

ANIMALIA; SUS SCROFA;

EID: 0242653652     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034915c     Document Type: Article

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