Coumestrol as well as isoflavones in soybean extract prevent bone resorption in ovariectomized rats

Endocrine Regulations

Volumn 37, Issue 3, 2003, Pages 145-152

  Ye, She Fang ^b   Saga, I ^b   Ichimura, K ^b   Nagai, T ^a   Shinoda, M ^a   Matsuzaki, Shigeru ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b Dokkyo University School of Medicine ^*

Author keywords

Coumestrol; Daidzein; Genistein; Soybean; Urinary deoxypyridinoline

Indexed keywords

COUMESTROL; DAIDZEIN; DEOXYPYRIDINOLINE; GENISTEIN; ISOFLAVONE DERIVATIVE; PYRIDINOLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFICACY; DRUG ISOLATION; ESTROGEN DEFICIENCY; FEMALE; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; RAT; SOYBEAN; THIN LAYER CHROMATOGRAPHY; URINARY EXCRETION; UTERUS WEIGHT;

AMINO ACIDS; ANIMALS; BONE RESORPTION; CHOLESTEROL; CHROMATOGRAPHY, THIN LAYER; COUMESTROL; ETHINYL ESTRADIOL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENISTEIN; ISOFLAVONES; ORGAN SIZE; OSTEOCALCIN; OVARIECTOMY; RANDOM ALLOCATION; RATS; RATS, WISTAR; SOYBEANS; UTERUS;

EID: 0242611481     PISSN: 12100668     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. ADLERCREUTZ H, MAZUR W: Phyto-estrogens and western diseases. Ann Med 29, 95-120, 1997
2. ALEKEL DL, GERMAIN AS, PETERSON CT, HANSON KB, STEWART JW, TODA T: Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 72, 844-852, 2000
3. ANDERSON JJB, GARNER SC: The effects of phytoestrogens on bone. Nutr Res 17, 1617-1632, 1997
4. ARMANDI BH, GETLINGER MJ, GOYAL NV, ALEKEL L, HASSLER CM, JUMA S, DRUM ML, HOLLIS BW, KUKREJA SC: Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. Am J Clin Nutr 68, 1358-1363, 1998
5. BICKOFF EM, LIVINGSTON AL, BOOTH AN: Estrogenic activity of coumestrol and related compounds. Arch Biochem Biophys 88, 262-266, 1960
6. COOPER C, CAMPION G, MELTON LJ III: Hip fracture in the elderly: Aworld-wide projection. Osteoporosis Int 2, 285-289, 1992
7. DODGE JA, GLASEBROOK AL, MAGEE DE, PHILLIPS DL, SATO M, SHORT LL, BRYANT HU: Environmental estrogens: effects on cholesterol lowering and bone in the ovariectomized rat. J Steroid Biochem Mol Biol 59, 155-161, 1996
8. DRAPER CR, EDEL MJ, DICK IM, RANDALL AG, MARTIN GB, PRINCE RL: Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats. J Nutr 127, 1795-1799, 1997
9. 3: a prospective, controlled randomized study. J Clin Endocrinol Metab 82, 2476-2482, 1997
10. HUTABARAT LS, GREENFIELD H, MULHOLLAND M: Quantitative determination of isoflavones and coumestrol in soybean by column liquid chromatography. J Chromatogr A 886, 55-63, 2000
11. ISHIMI Y, MIZAKURA C, OHMUTRA M, ONOE Y, SATO T, UCHUYAMA Y, ITO M, WANG XX, SUDA T, IKEGAMI S: Selective effects of genistein, a soybean isoflavone on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 140, 1893-1900, 1999
12. KAWASHIMA K, INOUE T, TSUTSUMI N, ENDO H: Effect of KCA-098 on the function of osteoblast-like cells and the formation of TRAP-positive multinucleated cells in a mouse bone marrow cell population. Biochem Pharmacol 51, 133-139, 1996
13. KNIGHT DC, EDEN JA: A review of the clinical effects of phytoestrogens. Obstet Gynecol 87, 897-904, 1996
14. KNUCKLES BE, DEFREMERY D, KOHLER GO: Coumestrol content of fractions obtained during wet processing of alfalfa. J Agric Food Chem 24, 1177-1180, 1976
15. KURZER MS, Xu X: Dietary phytoestrogens. Ann Rev Nutr 17, 353-381, 1997
16. LOOKHART GL, JONES BL, FINNEY KF: Determination of coumestrol in soybeans by high-performance liquid and thin-layer chromatography. Cereal Chem 55, 967-972, 1978
17. REINLL, K, BLOCK B: Phytoestrogen content of foods - a compendium of literature values. Nutr Cancer 26, 123-148, 1996
18. RICHMOND M: Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 12, 1350-1356, 1973
19. ROSSOUW JE, ANDERSON GL, PRENTICE RL, LACROIX AZ, KOOPERBERG C, STEFANICK ML, JACKSON RD, BERESFORD SA, HOWARD BV, JOHNSON KC, KOTCHEN JM, OCKENE J: Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 288, 321-333, 2002
20. SCARLATA S, MIKSICEK M: Binding properties of coumestrol to expressed human estrogen receptor. Mol Cell Endocrinol 115, 65-72, 1995
21. SETCHELL KDR: Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68 (suppl), 1333S-1346S, 1998
22. SOINE TO: Naturally occurring coumarins and related physiological activities. J Pharmaceut Sci 53, 231-264, 1964
23. STRAUSS L, SANTTI R, SAARINEN N, STRENG T, JOSHI S, MEKELA S: Dietary phytoestrogens and their role in hormonally dependent disease. Toxicol Lett 102/103, 349-354, 1998
24. THAM DM, GARDNER CD, HASKELL WL: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 83, 2223-2235, 1998
25. TSUTSUMI N: Effect of coumestrol on bone metabolism in organ culture. Biol Pharm Bull 18, 1012-1015, 1995
26. TSUTSUMI N, KAWASHIMA K, NAGATA H, TSUZUKI J, ITOH F, ARAI N, KOJIMA M, UJIIE A, ENDO H: Effects of KCA-098 on bone metabolism: comparison with those of ipriflavone. Jpn J Pharmacol 65, 343-349, 1994
27. TURNER RT, RIGGS BL, SPELSBERG TC: Skeletal effects of estrogen. Endocrine Rev 15, 275-300, 1994
28. VERDEAL K, RYAN DS: Naturally-occurring estrogens in plant foodstuffs - a review. J Food Protect 42, 577-583, 1979
29. VORE M, HADD H, SLIKKER W Jr: Ethinylestradiol-17beta D-ring glucuronide conjugates are potent cholestatic agents in the rat. Life Sci 32, 2989-2993, 1983