Novel Method for the Determination of Piperazine in Pharmaceutical Drug Substances Using Hydrophilic Interaction Chromatography and Evaporative Light Scattering Detection

Journal of Liquid Chromatography and Related Technologies

Volumn 26, Issue 18, 2003, Pages 3093-3104

  McClintic, Carlie ^a   Remick, David M ^b   Peterson, Jeffrey A ^b   Risley, Donald S ^b  

^a UNIVERSITY OF INDIANAPOLIS   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Counterion; Evaporative light scattering detector; High performance liquid chromatography; Hydrophilic interaction chromatography; Piperazine; Salt form

Indexed keywords

CATALYST SELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; OPTIMIZATION; ORGANIC ACIDS;

BONDED STATIONARY PHASE;

DRUG PRODUCTS;

2 BUTANONE; ACETONE; ACETONITRILE; ALCOHOL; CYANIDE; FORMIC ACID; HYDROCHLORIC ACID; LITHIUM CHLORIDE; NAPROXEN; NITRIC ACID; ORGANIC COMPOUND; PHENYLBUTAZONE; PIPERAZINE; PIPERAZINE CITRATE; PIPERAZINE DERIVATIVE; PIPERAZINE ESTRONE SULFATE; POTASSIUM BROMIDE; PROPANE; PYRAZINOBUTAZONE; SODIUM CHLORIDE; TRIFLUOROACETIC ACID;

ACCURACY; ANALYTIC METHOD; ARTICLE; CHEMICAL BOND; CHEMICAL COMPOSITION; CHROMATOGRAPHY; CHROMATOPHORE; DRUG DETERMINATION; DRUG PURITY; DRUG SELECTIVITY; DRUG STRUCTURE; EVALUATION; EVAPORATIVE LIGHT SCATTERING DETECTION; GRAVIMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIGHT SCATTERING; PARAMETER; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; TECHNIQUE; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 0242609344     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120025426     Document Type: Article

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