Antinociceptive effects of hydromorphone, bupivacaine and biphalin released from PLGA polymer after intrathecal implantation in rats

Biomaterials

Volumn 24, Issue 11, 2003, Pages 1969-1976

  Sendil, D ^a   Maszczynska Bonney, I ^b   Carr, D B ^b   Lipkowski, A W ^c   Wise, D L ^d   Hasirci, V ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^d Cambridge Scientific Inc   (United States)

Author keywords

Biphalin; Bupivacaine; Hydromorphone; Intrathecal drug delivery; PLGA; Polymer rod

Indexed keywords

DRUG DOSAGE; IMPLANTS (SURGICAL); NEUROLOGY;

CHRONIC PAIN CONTROL;

DRUG PRODUCTS;

BIPHALIN; BUPIVACAINE; HYDROMORPHONE; POLYGLACTIN;

ANTINOCICEPTION; ARTICLE; BIODEGRADATION; CHRONIC PAIN; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; IMPLANTATION; IN VIVO STUDY; MEASUREMENT; ONSET AGE; PRIORITY JOURNAL;

EID: 0242586059     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(02)00567-7     Document Type: Article

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