Continuous penicillin G hydrolysis in an electro-membrane reactor with immobilized penicillin G acylase

Biotechnology Letters

Volumn 25, Issue 6, 2003, Pages 485-490

  Zadražil, Aleš ^a   Chmelíková, Růžena ^a   Hasal, Pavel ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

Author keywords

Electric field; Immobilized enzyme; Mass transfer; Membrane reactor; Penicillin acylase

Indexed keywords

6 AMINOPENICILLANIC ACID; DRUG DERIVATIVE; IMMOBILIZED ENZYME; PENICILLANIC ACID; PENICILLIN AMIDASE; PENICILLIN G;

ARTICLE; ARTIFICIAL MEMBRANE; BIOREACTOR; CHEMISTRY; ELECTROCHEMISTRY; ELECTROMAGNETIC FIELD; ENZYME ACTIVATION; EQUIPMENT DESIGN; HYDROLYSIS; INSTRUMENTATION; METHODOLOGY; SYNTHESIS;

BIOREACTORS; ELECTROCHEMISTRY; ELECTROMAGNETIC FIELDS; ENZYME ACTIVATION; ENZYMES, IMMOBILIZED; EQUIPMENT DESIGN; HYDROLYSIS; MEMBRANES, ARTIFICIAL; PENICILLANIC ACID; PENICILLIN AMIDASE; PENICILLIN G;

EID: 0242585299     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022656129744     Document Type: Article

References (9)

1. Bossi A, Guerrera S, Righetti PG (1999) Electrically immobilized enzyme reactors: bioconversion of a charged substrate. Hydrolysis of penicillin G by penicillin G acylase. Biotechnol. Bioeng. 64: 383-391.
2. Chang YHD, Grodzinsky AJ, Wang DIC (1995) Augmentation of mass transfer through electrical means for hydrogel-entrapped Escherichia coli cultivation. Biotechnol. Bioeng. 48: 149-157.
3. Devaux-Basseguy R, Gros P, Bergel A (1997) Electroenzymatic processes: a clean technology alternative for highly selective synthesis? J. Chem. Technol. Biotechnol. 68: 389-396.
4. Huang TC, Chen DH, Wang SS (1996) Kinetic studies of penicillin g hydrolysis with immobilized penicillin acylase in an electrodialyzer. Chem. Eng. Commun. 147: 99-117.
5. Ishimura F, Suga KI (1992) Hydrolysis of penicillin G by combination of immobilized penicillin acylase and electrodialysis. Biotechnol. Bioeng. 39: 171-175.
6. Laval JM, Moiroux J, Bourdillon C (1991) The effect of electrochemical regeneration upon the enzymatic catalysis of a thermodynamically unfavorable reaction. Biotechnol. Bioeng. 38: 788-796.
7. Přibyl M, Chmelíková R, Hasal P, Marek M (2002) Dynamical behavior of penicillin G hydrolysis in an electro-membrane reactor. J. Chem. Technol. Biotechnol. 77: 51-62.
8. Pu HT, Yang RYK, Saus FL (1989) Iontophoretic release and transport of alkaloids from Catharanthus roseus cells in a ceramic hollow fiber reactor. Biotechnol. Lett. 11: 83-86.
9. Suga KI, Sorai T, Shioya S, Ishimura F (1993) Production of 6-aminopenicillanic acid in immobilized enzyme reactor with electrodialysis. J. Chem. Eng. Jpn. 26: 709-714.