메뉴 건너뛰기




Volumn 171, Issue 10, 2003, Pages 5064-5070

DQ 65-79, A Peptide Derived from HLA Class II, Mimics p21 to Block T Cell Proliferation

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; HLA ANTIGEN CLASS 2; HLA DQ A03011 ANTIGEN; HLA DQ ANTIGEN; HLA DQ ANTIGEN [65-79]; LIGAND; PEPTIDE DERIVATIVE; PROTEIN P21; UNCLASSIFIED DRUG;

EID: 0242580044     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.10.5064     Document Type: Article
Times cited : (10)

References (56)
  • 2
    • 0023865253 scopus 로고
    • Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes
    • Madsen, J. C., R. A. Superina, K. J. Wood, and P. J. Morris. 1988. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature 332:161.
    • (1988) Nature , vol.332 , pp. 161
    • Madsen, J.C.1    Superina, R.A.2    Wood, K.J.3    Morris, P.J.4
  • 3
    • 0027529337 scopus 로고
    • Induction of specific unresponsiveness using transfected cells expressing donor major histocompatibility complex molecules: Evidence for indirect presentation of allopeptides in vivo
    • Bell, Y., D. Shoskes, P. Morris, and K. Wood. 1993. Induction of specific unresponsiveness using transfected cells expressing donor major histocompatibility complex molecules: evidence for indirect presentation of allopeptides in vivo. Transplant. Proc. 25:359.
    • (1993) Transplant. Proc. , vol.25 , pp. 359
    • Bell, Y.1    Shoskes, D.2    Morris, P.3    Wood, K.4
  • 5
    • 0033029321 scopus 로고    scopus 로고
    • HLA-derived peptides as novel immunomodulatory therapeutics
    • Murphy, B., and A. M. Krensky. 1999. HLA-derived peptides as novel immunomodulatory therapeutics. J. Am. Soc. Nephrol. 10:1346.
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 1346
    • Murphy, B.1    Krensky, A.M.2
  • 7
    • 0027412593 scopus 로고
    • Peptides corresponding to T-cell receptor-HLA contact regions inhibit class I-restricted immune responses
    • Clayberger, C., S. C. Lyu, P. Pouletty, and A. M. Krensky. 1993. Peptides corresponding to T-cell receptor-HLA contact regions inhibit class I-restricted immune responses. Transplant. Proc. 25:477.
    • (1993) Transplant. Proc. , vol.25 , pp. 477
    • Clayberger, C.1    Lyu, S.C.2    Pouletty, P.3    Krensky, A.M.4
  • 8
    • 0023111422 scopus 로고
    • Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the α2 domain of HLA-A2
    • Parham, P., C. Clayberger, S. L. Zorn, D. S. Ludwig, G. K. Schoolnik, and A. M. Krensky. 1987. Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the α2 domain of HLA-A2. Nature 325:625.
    • (1987) Nature , vol.325 , pp. 625
    • Parham, P.1    Clayberger, C.2    Zorn, S.L.3    Ludwig, D.S.4    Schoolnik, G.K.5    Krensky, A.M.6
  • 9
    • 0032032267 scopus 로고    scopus 로고
    • Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65-79 of an HLA class II sequence: Functional similarities but mechanistic differences with the immunosuppressive drug rapamycin
    • Boytim, M. L., S. C. Lyu, R. Jung, A. M. Krensky, and C. Clayberger. 1998. Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65-79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug rapamycin. J. Immunol. 160:2215.
    • (1998) J. Immunol. , vol.160 , pp. 2215
    • Boytim, M.L.1    Lyu, S.C.2    Jung, R.3    Krensky, A.M.4    Clayberger, C.5
  • 11
    • 0028893272 scopus 로고
    • Inhibition of the alloimmune response with synthetic nonpolymorphic class II MHC peptides
    • Murphy, B., E. Akalin, B. Watschinger, C. B. Carpenter, and M. H. Sayegh. 1995. Inhibition of the alloimmune response with synthetic nonpolymorphic class II MHC peptides. Transplant. Proc. 27:409.
    • (1995) Transplant. Proc. , vol.27 , pp. 409
    • Murphy, B.1    Akalin, E.2    Watschinger, B.3    Carpenter, C.B.4    Sayegh, M.H.5
  • 13
    • 0031045565 scopus 로고    scopus 로고
    • PCNA: Structure, functions and interactions
    • Kelman, Z. 1997. PCNA: structure, functions and interactions. Oncogene 14:629.
    • (1997) Oncogene , vol.14 , pp. 629
    • Kelman, Z.1
  • 14
    • 0001298056 scopus 로고    scopus 로고
    • PCNA binding proteins
    • Tsurimoto, T. 1999. PCNA binding proteins. Front. Biosci. 4:849.
    • (1999) Front. Biosci. , vol.4 , pp. 849
    • Tsurimoto, T.1
  • 16
    • 0027981476 scopus 로고
    • Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme
    • Flores-Rozas, H., Z. Kelman, F. B. Dean, Z. Q. Pan, J. W. Harper, S. J. Elledge, M. O'Donnell, and J. Hurwitz. 1994. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme. Proc. Natl. Acad. Sci. USA 91:8655.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8655
    • Flores-Rozas, H.1    Kelman, Z.2    Dean, F.B.3    Pan, Z.Q.4    Harper, J.W.5    Elledge, S.J.6    O'Donnell, M.7    Hurwitz, J.8
  • 17
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga, S., G. J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:574.
    • (1994) Nature , vol.369 , pp. 574
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 18
    • 0028366116 scopus 로고
    • D-type cyclin-binding regions of proliferating cell nuclear antigen
    • Matsuoka, S., M. Yamaguchi, and A. Matsukage. 1994. D-type cyclin-binding regions of proliferating cell nuclear antigen. J. Biol. Chem. 269:11030.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11030
    • Matsuoka, S.1    Yamaguchi, M.2    Matsukage, A.3
  • 20
    • 0034595638 scopus 로고    scopus 로고
    • Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains: PCNA impedes MyD118 and Gadd45-mediated negative growth control
    • Vairapandi, M., N. Azam, A. G. Balliet, B. Hoffman, and D. A. Liebermann. 2000. Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains: PCNA impedes MyD118 and Gadd45-mediated negative growth control. J. Biol. Chem. 275:16810.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16810
    • Vairapandi, M.1    Azam, N.2    Balliet, A.G.3    Hoffman, B.4    Liebermann, D.A.5
  • 21
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks, and microprocessors
    • Morgan, D. O. 1997. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell. Dev. Biol. 13:261.
    • (1997) Annu. Rev. Cell. Dev. Biol. , vol.13 , pp. 261
    • Morgan, D.O.1
  • 23
    • 0027440552 scopus 로고
    • Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
    • Zhang, H., Y. Xiong, and D. Beach. 1993. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Biol. Cell 4:897.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 897
    • Zhang, H.1    Xiong, Y.2    Beach, D.3
  • 24
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu, Y., C. W. Turck, and D. O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366:707.
    • (1993) Nature , vol.366 , pp. 707
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 25
    • 0030592544 scopus 로고    scopus 로고
    • Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA
    • Gulbis, J. M., Kelman, Z., Hurwitz, J., M. O'Donnell, and J. Kuriyan. 1996. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 87:297.
    • (1996) Cell , vol.87 , pp. 297
    • Gulbis, J.M.1    Kelman, Z.2    Hurwitz, J.3    O'Donnell, M.4    Kuriyan, J.5
  • 27
    • 0029973557 scopus 로고    scopus 로고
    • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors
    • Adams P. D., W. R. Sellers, S. K. Sharma, A. D. Wu, C. M. Nalin, and W. G. Kaelin, Jr. 1996. Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol. Cell. Biol. 16:6623.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6623
    • Adams, P.D.1    Sellers, W.R.2    Sharma, S.K.3    Wu, A.D.4    Nalin, C.M.5    Kaelin Jr., W.G.6
  • 28
    • 0031025385 scopus 로고    scopus 로고
    • Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1
    • Ball, K. L., S. Lain, R. Fahraeus, C. Smythe, and D. P. Lane. 1997. Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1. Curr. Biol. 7:71.
    • (1997) Curr. Biol. , vol.7 , pp. 71
    • Ball, K.L.1    Lain, S.2    Fahraeus, R.3    Smythe, C.4    Lane, D.P.5
  • 30
    • 0029873287 scopus 로고    scopus 로고
    • A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo
    • Chen, J., R. Peters, P. Saha, P. Lee., A. Theodoras, M. Pagano, G. J. Wagner, and A. Dutta. 1996. A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo. Nucleic Acid Res. 24:1727.
    • (1996) Nucleic Acid Res. , vol.24 , pp. 1727
    • Chen, J.1    Peters, R.2    Saha, P.3    Lee, P.4    Theodoras, A.5    Pagano, M.6    Wagner, G.J.7    Dutta, A.8
  • 32
    • 0029021714 scopus 로고
    • Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor
    • Goubin, F., and B. Ducommun. 1995. Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor. Oncogene 10:2281.
    • (1995) Oncogene , vol.10 , pp. 2281
    • Goubin, F.1    Ducommun, B.2
  • 33
    • 0028982946 scopus 로고
    • The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition
    • Nakanishi, M., R. S. Robetorye, O. M. Periera-Smith, and J. R. Smith. 1995. The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition. J. Biol. Chem. 21:17060.
    • (1995) J. Biol. Chem. , vol.21 , pp. 17060
    • Nakanishi, M.1    Robetorye, R.S.2    Periera-Smith, O.M.3    Smith, J.R.4
  • 34
    • 0029257341 scopus 로고
    • A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
    • Warbrick, E., D. P. Lane, D. M. Glover, and L. S. Cox. 1995. A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. Curr. Biol. 5:275.
    • (1995) Curr. Biol. , vol.5 , pp. 275
    • Warbrick, E.1    Lane, D.P.2    Glover, D.M.3    Cox, L.S.4
  • 35
    • 0036533511 scopus 로고    scopus 로고
    • DQ 65-79, a peptide derived from HLA class II, induces IκB expression
    • Jiang, Y., D. Chen, S. C. Lyu, X. Ling, A. M. Krensky, and C. Clayberger. 2002. DQ 65-79, a peptide derived from HLA class II, induces IκB expression. J. Immunol. 168:3323.
    • (2002) J. Immunol. , vol.168 , pp. 3323
    • Jiang, Y.1    Chen, D.2    Lyu, S.C.3    Ling, X.4    Krensky, A.M.5    Clayberger, C.6
  • 36
  • 37
    • 0034738420 scopus 로고    scopus 로고
    • p21(WAF1/Cip): More than a break to the cell cycle?
    • Dotto, G. P. 2000. p21(WAF1/Cip): more than a break to the cell cycle? Biochim. Biophys. Acta 1471:43.
    • (2000) Biochim. Biophys. Acta , vol.1471 , pp. 43
    • Dotto, G.P.1
  • 38
    • 0032864677 scopus 로고    scopus 로고
    • The C-terminal domain of p21 inhibits nucleotide excision repair in vitro and in vivo
    • Cooper, M. P., A. S. Balajee, and V. A. Bohr. 1999. The C-terminal domain of p21 inhibits nucleotide excision repair in vitro and in vivo. Mol. Biol. Cell 10:2119.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2119
    • Cooper, M.P.1    Balajee, A.S.2    Bohr, V.A.3
  • 39
    • 0034720729 scopus 로고    scopus 로고
    • A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: Affinity, stoichiometry, and thermodynamics
    • Zheleva, D. I., N. Z. Zhelev, P. M. Fischer, S. V. Duff, E. Warbrick, D. G. Blake, and D. P. Lane. 2000. A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: affinity, stoichiometry, and thermodynamics. Biochemistry 39:7388.
    • (2000) Biochemistry , vol.39 , pp. 7388
    • Zheleva, D.I.1    Zhelev, N.Z.2    Fischer, P.M.3    Duff, S.V.4    Warbrick, E.5    Blake, D.G.6    Lane, D.P.7
  • 40
    • 0032569982 scopus 로고    scopus 로고
    • PCNA, a multifunctional ring on DNA
    • Tsurimoto, T. 1998. PCNA, a multifunctional ring on DNA. Biochim. Biophys. Acta 1443 23.
    • (1998) Biochim. Biophys. Acta , vol.1443 , pp. 23
    • Tsurimoto, T.1
  • 41
    • 0032126403 scopus 로고    scopus 로고
    • Protein-PCNA interactions: A DNA-scanning mechanism?
    • Kelman, Z., and J. Hurwitz. 1998. Protein-PCNA interactions: a DNA-scanning mechanism? Trends Biochem. Sci. 23:236.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 236
    • Kelman, Z.1    Hurwitz, J.2
  • 42
    • 0024364302 scopus 로고
    • Regulation of proliferating cell nuclear antigen during the cell cycle
    • Morris, G. F., and M. B. Mathews. 1989. Regulation of proliferating cell nuclear antigen during the cell cycle. J. Biol. Chem. 264:13856.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13856
    • Morris, G.F.1    Mathews, M.B.2
  • 43
    • 0028605473 scopus 로고
    • Nuclear distribution of proliferating cell nuclear antigen (PCNA) in fertilized eggs of the starfish Asterina pectinifera
    • Nomura, A. 1994. Nuclear distribution of proliferating cell nuclear antigen (PCNA) in fertilized eggs of the starfish Asterina pectinifera. J. Cell. Sci. 107:3291.
    • (1994) J. Cell. Sci. , vol.107 , pp. 3291
    • Nomura, A.1
  • 45
    • 0034725635 scopus 로고    scopus 로고
    • A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation
    • Koundrioukoff, S., Z. O. Jonsson, S. Hasan, R. N. de Jong, P. C. van der Vliet, M. O. Hottiger, and U. Hubscher. 2000. A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation. J. Biol. Chem. 275:22882.
    • (2000) J. Biol. Chem. , vol.275 , pp. 22882
    • Koundrioukoff, S.1    Jonsson, Z.O.2    Hasan, S.3    De Jong, R.N.4    Van Der Vliet, P.C.5    Hottiger, M.O.6    Hubscher, U.7
  • 47
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell. Res. 211:90.
    • (1994) Exp. Cell. Res. , vol.211 , pp. 90
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 48
    • 0034646679 scopus 로고    scopus 로고
    • Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
    • Scott, M. T., N. Morrice, and K. L. Ball. 2000. Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. J. Biol. Chem. 275:11529.
    • (2000) J. Biol. Chem. , vol.275 , pp. 11529
    • Scott, M.T.1    Morrice, N.2    Ball, K.L.3
  • 49
    • 0032539602 scopus 로고    scopus 로고
    • Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen
    • Watanabe, H., Z. Q. Pan, N. Schreiber-Agus, R. A. DePinho, J. Hurwitz, and Y. Xiong. 1998. Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proc. Natl. Acad. Sci. USA 95:1392.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1392
    • Watanabe, H.1    Pan, Z.Q.2    Schreiber-Agus, N.3    DePinho, R.A.4    Hurwitz, J.5    Xiong, Y.6
  • 50
    • 0028899480 scopus 로고
    • Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
    • Chen, J., P. K. Jackson, M. W. Kirschner, and A. Dutta. 1995. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374:386.
    • (1995) Nature , vol.374 , pp. 386
    • Chen, J.1    Jackson, P.K.2    Kirschner, M.W.3    Dutta, A.4
  • 51
    • 0030615324 scopus 로고    scopus 로고
    • p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth
    • Bonfanti, M., S. Taverna, M. Salmona, M. D'Incalci, and M. Broggini. 1997. p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth. Cancer Res. 57:1442.
    • (1997) Cancer Res. , vol.57 , pp. 1442
    • Bonfanti, M.1    Taverna, S.2    Salmona, M.3    D'Incalci, M.4    Broggini, M.5
  • 52
    • 0033565263 scopus 로고    scopus 로고
    • A p21(Waf1/Cip1) carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells
    • Mutoh, M., F. D. Lung, Y. Q. Long, P. P. Roller, R. S. Sikorski, and P. M. O'Connor. 1999. A p21(Waf1/Cip1) carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells. Cancer Res. 59:3480.
    • (1999) Cancer Res. , vol.59 , pp. 3480
    • Mutoh, M.1    Lung, F.D.2    Long, Y.Q.3    Roller, P.P.4    Sikorski, R.S.5    O'Connor, P.M.6
  • 54
    • 0029016275 scopus 로고
    • Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21
    • Podust, V. N., L. M. Podust, F. Goubin, B. Ducommun, and U. Hubscher. 1995. Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21. Biochemistry 34:8869.
    • (1995) Biochemistry , vol.34 , pp. 8869
    • Podust, V.N.1    Podust, L.M.2    Goubin, F.3    Ducommun, B.4    Hubscher, U.5
  • 55
    • 0030913166 scopus 로고    scopus 로고
    • Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: A potential mechanism to co-ordinate DNA replication and repair
    • Warbrick, E., D. P. Lane, D. M. Glover, and L. S. Cox. 1997. Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair. Oncogene 14:2313.
    • (1997) Oncogene , vol.14 , pp. 2313
    • Warbrick, E.1    Lane, D.P.2    Glover, D.M.3    Cox, L.S.4
  • 56
    • 0030770835 scopus 로고    scopus 로고
    • Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1
    • Chuang, L. S., H. I. Ian, T. W. Koh, H. H. Nam, G. Xu, and B. F. Li. 1997. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277:1996.
    • (1997) Science , vol.277 , pp. 1996
    • Chuang, L.S.1    Ian, H.I.2    Koh, T.W.3    Nam, H.H.4    Xu, G.5    Li, B.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.