In vitro inhibition of human neutrophil histotoxicity by ambroxol: Evidence for a multistep mechanism

British Journal of Pharmacology

Volumn 140, Issue 4, 2003, Pages 736-742

  Ottonello, Luciano ^a   Arduino, Nicoletta ^a   Bertolotto, Maria ^a   Dapino, Patrizia ^a   Mancini, Marina ^a   Dallegri, Franco ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Alpha 1 antitrypsin; Ambroxol; Elastase; Inflammation; Neutrophils; Oxidants; Pulmonary diseases

Indexed keywords

5,5 DIMETHYL 1,3 CYCLOHEXANEDIONE; ALPHA 1 ANTITRYPSIN; AMBROXOL; BROMHEXINE; ELASTASE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; OXIDIZING AGENT; PROTEINASE; PROTEINASE INHIBITOR; SUPEROXIDE;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CELL PROTECTION; CHLORINATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; CYTOTOXICITY; DRUG ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LUNG DISEASE; LUNG FIBROSIS; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; TISSUE INJURY;

ALPHA 1-ANTITRYPSIN; AMBROXOL; BROMHEXINE; CHLORIDES; CYCLOHEXANONES; CYTOCHALASINS; CYTOPLASMIC GRANULES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXOCYTOSIS; HUMANS; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; LEUKOCYTE ELASTASE; NEUTROPHIL ACTIVATION; PEROXIDASE; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 0242576823     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705497     Document Type: Article

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