Relationship between CpG Methylation of p16 Gene and Sporatic Colorectal Cancer

Acta Genetica Sinica

Volumn 30, Issue 11, 2003, Pages 1061-1064

  Yang, Yu Hua ^a   He, Xiao Bing ^a   Zhang, Feng Rui ^a   Zhang, Jian Qiong ^a   Xie, Wei ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

DNA methylation; MSP; P16; Sequencing; Sporatic colorectal cancer

Indexed keywords

DNA;

ARTICLE; CANCER INVASION; CANCER STAGING; CLINICAL ARTICLE; COLORECTAL CANCER; CPG ISLAND; DNA SEQUENCE; GENE FREQUENCY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERMETHYLATION; LYMPH NODE METASTASIS; METHYLATION; POLYMERASE CHAIN REACTION; PROTEIN METHYLATION; TUMOR SUPPRESSOR GENE;

EID: 0242527188     PISSN: 03794172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Suter C M, Norrie M, Ku S L, Cheong K F, Tomlinson I, Ward R L. CpG island methylation is a common finding in colorectal cancer cell lines. Br J Cancer, 2003,88(3):413-419.
2. Herman J G, Graff J R, Myohanen S, Nelkin B D, Baylin S B. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA, 1996,93(18):9821-9826.
3. Clark S J, Harrison J, Paul C L, Frommer M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res, 1994,22(15):2990-2997.
4. Jubb A M, Bell S M, Quirke P. Methylation and colorectal cancer. J Pathol, 2001,195(1):111-134.
5. Serrano M, Hannon G J, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature, 1993, 366(6456):704-707.
6. Herman J G, Merlo A, Mao L, Lapidus R G, Issa J P, Davidson N E, Sidransky D, Baylin S B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res, 1995,55(20):4525-4530.
7. DUAN Xiao-Ming, HE Xiu-Sheng. Deletion and mutation of p16 gene in colorecral carcinoma. Zhongliu Fangzhi Zazhi, 2001,8(2):139-141.