The Organization and Assembly of a β-Sheet Formed by a Prion Peptide in Solution: An Isotope-Edited FTIR Study

Journal of the American Chemical Society

Volumn 125, Issue 45, 2003, Pages 13674-13675

  Gangani, R A ^a   Silva, D ^a   Barber Armstrong, Wendy ^a   Decatur, Sean M ^a  

^a MOUNT HOLYOKE COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

H1 PEPTIDE; ISOTOPE; PRION PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; INFRARED SPECTROSCOPY; ISOTOPE LABELING; MOLECULAR DYNAMICS; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; CARBON ISOTOPES; KINETICS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PRPC PROTEINS; SOLUTIONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 0242490659     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036725v     Document Type: Article

References (25)

1. (a) Dobson, C. M. Nature 2002, 418, 729-730.
2. (b) Dobson, C. M. Philos. Trans. R. Soc. London, Ser. B 2001, 356, 133-145.
3. Soto, C. FEBS Lett. 2001, 498, 204-207.
4. Tagliavini, F.; Forloni, G.; D'Ursi, P.; Bugiani, O.; Salmona, M. Adv. Protein Chem. 2001, 57, 171-201.
5. Cohen, F. E.; Prusiner, S. B. Annu. Rev. Biochem. 1998, 67, 793-819.
6. (a) Gasset, M.; Baldwin, M. A.; Lioyd, D. H.; Gabriel, J.; Holtzman, D. M.; Cohen, F.; Fletterick, R.; Prusiner, S. B. Proc. Natl. Acad. Sci. U.S.A. 1989, 89, 10940-10944.
7. (b) Pan, K. H.; Baldwin, M.; Nguyen, J.; Gasset, M.; Serban, A.; Groth, D.; Mehihom, I.; Huang, Z.; Fletterick, R.; Cohen, F. E.; Prusiner, S. B. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 10962-10966.
8. (a) Decatur, S. M.; Antonic, J. A. J. Am. Chem. Soc. 1999, 121, 11914-11915.
9. (b) Silva, R. A. G. D.; Kubelka, J.; Decatur, S. M.; Bour, P.; Keiderling, T. A. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 8318-8323.
10. (c) Silva, R. A. G. D.; Nguyen, J. Y.; Decatur, S. M. Biochemistry 2002, 41, 15296-15303.
11. (d) Venyaminov, S. Y.; Hedstrom, J. F.; Prendergast, F. G. Proteins: Struct., Funct., Genet. 2001, 45, 81-89.
12. (e) Hung, C. Y.; Getahun, Z.; Wang, T.; DeGrado, W. F.; Gai, F. J. Am. Chem. Soc. 2001, 123, 12111-12112.
13. Nguyen, J.; Baldwin, M. A.; Cohen, F. E.; Prusiner, S. B. Biochemistry 1995, 34, 4186-4192.
14. (a) Halverson, K.; Sucholeiki, I.; Ashburn, T. T.; Lansbury, R. T. J. Am. Chem. Soc. 1991, 113, 6701-6703.
15. (b) Baldwin, M. A. Methods Enzymol. 2001, 309, 576-591.
16. 2O at room temperature and freeze-dried.
17. -1 resolution averaging 256 scans.
18. Jackson, M.; Mantsch, H. H. Crit. Rev. Biochem. Mol. Biol. 1995, 30, 95.
19. Ultraviolet circular dichroism (CD) spectra recorded on H1 at 75 °C suggest that a mixture of α-helix and random coil conformations is present.
20. 13C labels in β-sheet and aggregate peptides. (a) Kubelka, J.; Keiderling, T. A. J. Am. Chem. Soc. 2001, 123, 6142-6150.
21. (b) Brauner, J. W.; Dugan, C.; Mendelsohn, R. J. Am. Chem. Soc. 2000, 122, 677-683.
22. (a) Brown, D. R. Biochem. J. 2000, 346, 785-791.
23. (b) Okimoto, N.; Yamanaka, K.; Suenaga, A.; Hata, M.; Hoshino, T. Biophys. J. 2002, 82, 2746-2757.
24. (c) A peptide based on the sequence of residues 106 through 126 and containing 3 alanine to valine substitutions at positions 113, 115, and 118 also shows significant enhancement of β-sheet fibril formation.
25. (d) Inouye, H.; Bond, J.; Baldwin, M. A.; Ball, H. L.; Prusiner, S. B.; Kirschner, D. A. J. Mol. Biol. 2000, 300, 1283-129.