Cyclosporin and tacrolimus do not potentiate oxidative damage in pulmonary epithelial cells

Transplant International

Volumn 16, Issue 10, 2003, Pages 709-712

  Mogayzel, Peter J ^a   Wagner, Traci L ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Cyclosporine; Hydrogen peroxide; Oxidative injury; Pulmonary epithelial cells; Tacrolimus

Indexed keywords

CYCLOSPORIN A; HYDROGEN PEROXIDE; TACROLIMUS;

ALLOGRAFT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG TRANSPLANTATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENOCARCINOMA; CELL LINE, TUMOR; CELL SURVIVAL; CYCLOSPORINE; HUMANS; HYDROGEN PEROXIDE; LUNG NEOPLASMS; OXIDATIVE STRESS; RESPIRATORY MUCOSA; TACROLIMUS;

EID: 0242474366     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2003.tb00228.x     Document Type: Article

References (14)

1. Stammberger U, Gaspert A, Hillinger S, et al. (2000) Apoptosis induced by ischemia and reperfusion in experimental lung transplantation. Ann Thorac Surg 69:1532
2. Fischer S, Maclean AA, Liu M, et al. (2000) Dynamic changes in apoptotic and necrotic cell death correlate with severity of ischemia-reperfusion injury in lung transplantation. Am J Respir Crit Care Med 162:1932
3. Fischer S, Cassivi SD, Xavier AM, et al. (2000) Cell death in human lung transplantation: apoptosis induction in human lungs during ischemia and after transplantation. Ann Surg 231:424
4. Hansen PR, Holm AM, Svendsen UG, Olsen PS, Andersen CB (1999) Apoptosis in acute pulmonary allograft rejection and cytomegalovirus infection. APMIS 107:529
5. Szabolcs MJ, Ravalli S, Minanov O, Sciacca RR, Michler RE, Cannon PJ (1998) Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection. Transplantation 65:804
6. Hansen PR, Holm AM, Svendsen UG, Olsen PS, Andersen CB. Apoptosis and formation of peroxynitrite in the lungs of patients with obliterative bronchiolitis. J Heart Lung Transplant 19:160
7. McGrath-Morrow SA, Stahl J (2001) Growth arrest in A549 cells during hyperoxic stress is associated with decreased cyclin B1 and increased p21 (Waf1/Cip1/Sdi1) levels. Biochim Biophys Acta 1538:90
8. O'Reilly MA, Staversky RJ, Watkins RH, et al. (2001) The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol 24:703
9. O'Reilly MA (2001) DNA damage and cell cycle checkpoints in hyperoxic lung injury: breaking to facilitate repair. Am J Physiol Lung Cell Mol Physiol 281:L291
10. Zhang JG, Walmsley MW, Moy JV, et al. (1998) Differential effects of cyclosporin A and tacrolimus on the production of TGF-beta: implications for the development of obliterative bronchiolitis after lung transplantation. Transpl Int [Suppl 11]:S325
11. Khanna AK, Hosenpud JD (1999) Cyclosporine induces the expression of the cyclin inhibitor p21. Transplantation 67:1262
12. Jarvinen K, Pietarinen-Runtti P, Linnainmaa K, et al. (2000) Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol 278:L696
13. Watanabe N, Dickinson DA, Krzywanski DM, et al. (2002) A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile. Am J Physiol Lung Cell Mol Physiol 283:L726
14. Riise GC, Williams A, Kjellstrom C, Schersten H, Andersson BA, Kelly FJ (1998) Bronchiolitis obliterans syndrome in lung transplant recipients is associated with increased neutrophil activity and decreased antioxidant status in the lung. Eur Respir J 12:82