A novel method of deriving the effect compartment equilibrium rate constant for propofol

British Journal of Anaesthesia

Volumn 91, Issue 5, 2003, Pages 730-732

  Lim, T A ^a  

^a Universiti Putra   (Malaysia)

Author keywords

Anaesthetics, i.v., propofol; Model, computer simulation; Pharmacokinetics

Indexed keywords

PROPOFOL;

ADULT; ANESTHESIA INDUCTION; ARTICLE; BOLUS INJECTION; CENTRAL NERVOUS SYSTEM; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG INFUSION; DRUG MECHANISM; ELECTRONICS; EYELASH; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; MONITOR; PHARMACODYNAMICS; PREDICTION; PRIORITY JOURNAL; REFLEX;

EID: 0242467608     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeg228     Document Type: Article

References (10)

1. Lim TA, Inbasegaran K. Predicted effect compartment concentration of thiopental at loss of the eyelash reflex. Br J Anaesth 2001; 86: 422-4
2. Schnider TW, Minto CF, Gambus PL, et al. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology 1998; 88: 1170-82
3. Gentry WB, Krejcie TC, Henthorn TK, et al. Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model. Anesthesiology 1994; 81: 316-24
4. Marsh B, White M, Morton N, Kenny GNC. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 1991; 67: 41-8
5. Schnider TW, Minto CF, Shafer SL, et al. The influence of age on propofol pharmacodynamics. Anesthesiology 1999; 90: 1502-16
6. Struys M, De Smet T, Depoorter B, et al. Comparison of plasma compartment versus two methods for effect compartment-controlled target-controlled infusion for propofol. Anesthesiology 2000; 92: 399-406
7. Wakeling HG, Zimmerman JB, Howell S, Glass PS. Targeting effect compartment or central compartment concentration of propofol: what predicts loss of consciousness? Anesthesiology 1999; 90: 92-7
8. Leslie K, Sessler DI, Smith WD, et al. Prediction of movement during propofol/nitrous oxide anesthesia. Performance of concentration, electroencephalographic, pupillary, and hemodynamic indicators. Anesthesiology 1996; 84: 52-63
9. Vuyk J, Engbers FHM, Lemmens HJM, et al. Pharmacodynamics of propofol in female patients. Anesthesiology 1992; 77: 3-9
10. Forrest FC, Tooley MA, Saunders PR, Prys-Roberts C. Propofol infusion and the suppression of consciousness: the EEG and dose requirements. Br J Anaesth 1994; 72: 35-41