Regulation of type 1 inositol 1,4,5-trisphosphate-gated calcium channels by InsP3 and calcium: Simulation of single channel kinetics based on ligand binding and electrophysiological analysis

Journal of General Physiology

Volumn 113, Issue 6, 1999, Pages 837-849

  Moraru, I I ^a   Kaftan, E J ^b   Ehrlich, B E ^c   Watras, J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Calcium signaling; Cerebellum; Inositol 1,4,5 trisphosphate receptor; Intracellular calcium channel; Kinetic model

Indexed keywords

CALCIUM; CALCIUM CHANNEL; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CEREBELLUM; CHANNEL GATING; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; DOG; MATHEMATICAL MODEL; MOLECULAR MODEL; NONHUMAN; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL MEMBRANE; CEREBELLUM; DOGS; ELECTROPHYSIOLOGY; INOSITOL 1,4,5-TRISPHOSPHATE; ION CHANNEL GATING; KINETICS; LIGANDS; MICROSOMES; MODELS, CHEMICAL;

EID: 0032970499     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.113.6.837     Document Type: Article

References (39)

1. Abdel-Latif, A. 1986. Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers. Pharmacol. Rev. 38:227-272.
2. Benevolensky, D., I. Moraru, and J. Watras. 1994. Micromolar calcium reduces the affinity of the inositol 1,4,5-trisphosphate receptor in smooth muscle. Biochem. J. 299:631-636.
3. Berridge, M.J., and R.F. Irvine. 1989. Inositol phosphates and cell signalling. Nature. 341:197-205.
4. Bezprozvanny, I. 1994. Theoretical analysis of calcium wave propagation based on inositol (1,4,5)-trisphosphate (InsP3) receptor functional properties. Cell Calc. 16:151-166.
5. 3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature. 351: 751-754.
6. 2+. Biochem. J. 306:445-451.
7. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
8. Chadwick, C.C., A. Saito, and S. Fleischer. 1990. Isolation and characterization of the inositol trisphosphate receptor from smooth muscle. Proc. Natl. Acad. Sci. USA. 87:2132-2136.
9. Clapham, D.E. 1995. Calcium signaling. Cell. 80:259-268.
10. Colquhoun, D., and A.G. Hawkes. 1983. The principles of the stochastic interpretation of ion-channel mechanisms. In Single Channel Recording. Plenum Publishing Corp., New York. 135-176.
11. De Young, G.W., and J. Keizer. 1992. A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca concentration. Proc. Natl. Acad. Sci. USA. 89:9895-9899.
12. Fabiato, A. 1988. Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. Methods Enzymol. 157:378-417.
13. Finch, E.A., T.J. Turner, and S.M. Goldin. 1991. Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release. Science. 252:443-446.
14. Hannaert-Merah, Z., L. Combettes, J.-F. Coquil, S. Swillens, J.-P. Mauger, M. Claret, and P. Champeil. 1995. Characterization of the co-agonist effects of strontium and calcium on myo-inositol trisphosphate-dependent ion fluxes in cerebellar microsomes. Cell Calc. 18:390-399.
15. Hille, B. 1992. Cating mechanisms. In Ionic Channels of Excitable Membranes. Sinauer Associates, Inc., Sunderland, MA. 472-504.
16. Horn, R. 1991. Estimating the number of channels in patch recordings. Biophys. J. 60:433-439.
17. 2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci. J. Gen. Physiol. 95:1103-1122.
18. Joseph, S.K., H.L. Rice, and J.R. Williamson. 1989. The effect of external calcium and pH on inositol trisphosphate-mediated calcium release from cerebellum microsomal fractions. Biochem. J. 258:261-265.
19. 3 receptor-dependent calcium signaling. J. Gen. Physiol. 110:529-538.
20. 2+ release in rat cerebellar Purkinje neurones. J. Physiol. 487:343-358.
21. Maeda, N., M. Niinobe, K. Nakahira, and K. Mikoshiba. 1988. Purification and characterization of P400 protein, a glycoprotein characteristic of Purkinje cell, from mouse cerebellum. J. Neurochem. 51:1724-1730.
22. Marshall, I., and C. Taylor. 1994. Two calcium binding sites mediate the interconversion of liver inositol 1,4,5-trisphosphate receptors between three conformations states. Biochem. J. 301:591-598.
23. 3) binding to the cerebellar InsP3 receptor. J. Biol. Chem. 267:7450-74.55.
24. Payne, R., T.M. Flores, and A. Fein. 1990. Feedback inhibition by calcium limits the release of calcium by inositol trisphosphate in Limulus ventral photoreceptors. Neuron. 4:547-555.
25. 2+ spiking depending on its concentration. FEBS Lett. 293:179-182.
26. Putney, J. 1990. The integration of receptor-regulated intracellular calcium release and calcium entry across the plasma membrane. Curr. Top. Cell Regul. 31:111-127.
27. 2+ binding site in the type 1 inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 271:27005-27012.
28. 2+-binding domains in the type 1 inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 272:25899-25906.
29. 2+. J. Gen. Physiol. 108:115-124.
30. 3 receptor. EMBO (Eur. Mol. Biol. Organ.) J. 10:3199-3206.
31. Supattapone, S., P.F. Worley, J.M. Baraban, and S.H. Snyder. 1988. Solubilization, purification, and characterization of an inositol trisphosphate receptor. J. Biol. Chem. 263:1530-1534.
32. 2+ transients. Cell Calc. 23:291-302.
33. 3-sensitive calcium channel kinetics. Biophys. J. 70:246-263.
34. Testa, B., P. Jenner, G.J. Kilpattick, N. el Tayar, H. Van de Waterbeemd, and C.D. Marsden. 1987. Do thermodynamic studies provide information on both the binding to and the activation of dopaminergic and other receptors? Biochem. Pharmacol. 36:4041-4046.
35. Wakui, M., B.V.L. Potter, and O.H. Petersen. 1989. Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration. Nature. 339:317-320.
36. Watras, J., I. Bezprozvanny, and B.E. Ehrlich. 1991. Inositol 1,4,5-trisphosphate-gated channels in cerebellum - presence of multiple conductance states. J. Neurosci. 11:3239-3245.
37. Watras, J., I. Moraru, D.J. Costa, and L.A. Kindman. 1994. Two inositol 1,4,5-trisphosphate binding sites in rat basophilic leukemia cells: relationship between receptor occupancy and calcium release. Biochemistry, 33:14359-14367.
38. Wojcikiewicz, R.J. 1995. Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types. J. Biol. Chem. 270:11678-11683.
39. Worley, P.F., J.M. Baraban, S. Supattapone, V.S. Wilson, and S.H. Snyder. 1987. Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium. J. Biol. Chem. 262:12132-12136.