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Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate
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Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer
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Methylation of the 5′ CpG island of the endothelin B receptor gene is common in human prostate cancer
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Endothelin inhibits osteoclastic bone resorption by a direct effect on cell motility: Implications for the vascular control of bone resorption
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New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade
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16
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Pharmacological characterization of A-127722: An orally active and highly potent ETA-selective receptor antagonist
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Carducci, M. A., Nelson, J. B., Bowling, M. K., Rogers, T., Eisenberger, M. A., Sinibaldi, V. et al: Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: safety and pharmacokinetics. J Clin Oncol, 20: 2171, 2002
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0001075906
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Preliminary phase II results using ABT-627, an endothelin-A selective receptor antagonist, in men with symptomatic hormone refractory prostate cancer
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abstract 709
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Nelson, J. B., Carducci, M. A., Dawson, M., Hippensteel, R. L., Padley, R. J. and Janus, T. J.: Preliminary phase II results using ABT-627, an endothelin-A selective receptor antagonist, in men with symptomatic hormone refractory prostate cancer. J Urol, suppl., 163: 159, abstract 709, 2000
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19
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0003265455
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The endothelin-A receptor antagonist atrasentan (ABT-627) delays clinical progression in hormone refractory prostate cancer: A multinational, randomized, double-blind, placebo-controlled trial
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abstract 694
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Carducci, M. A., Nelson, J. B., Padley, R. J., Janus, T. and Hippensteel, R.: The endothelin-A receptor antagonist atrasentan (ABT-627) delays clinical progression in hormone refractory prostate cancer: a multinational, randomized, double-blind, placebo-controlled trial. Proc Am Soc Clin Oncol, 20: 174a, abstract 694, 2001
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20
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0003265457
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The endothelin-A receptor antagonist atrasentan (ABT-627) reduces skeletal remodeling activity in men with advanced, hormone refractory prostate cancer
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abstract 12
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Nelson, J. B., Carducci, M. A., Padley, R. J., Janus, T., Humerickhouse, R. and Hippensteel, R.: The endothelin-A receptor antagonist atrasentan (ABT-627) reduces skeletal remodeling activity in men with advanced, hormone refractory prostate cancer. Proc Am Soc Clin Oncol, 20: 4a, abstract 12, 2001
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Nelson, J.B.1
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Padley, R.J.3
Janus, T.4
Humerickhouse, R.5
Hippensteel, R.6
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