Gender differences in organ density in a rat simulated microgravity model

Acta Astronautica

Volumn 54, Issue 2, 2004, Pages 133-138

  Pettis, Christopher Ryan ^a   Witten, Mark Lee ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; BRAIN; COMPUTER SIMULATION; COMPUTERIZED TOMOGRAPHY; HORMONES;

ORGAN DENSITY;

MICROGRAVITY PROCESSING;

ESTROGEN;

ADAPTATION; ANIMAL; ARTICLE; BRAIN; COMPARATIVE STUDY; DRUG EFFECT; ESTROGEN THERAPY; FEMALE; FISCHER 344 RAT; FLUID SHIFT; HEART; HISTOLOGY; KIDNEY; LIVER; LUNG; ORGAN SIZE; OVARIECTOMY; PHYSIOLOGY; RADIOGRAPHY; RAT; SEX DIFFERENCE; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; WEIGHTLESSNESS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BRAIN; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; FLUID SHIFTS; HEART; KIDNEY; LIVER; LUNG; ORGAN SIZE; OVARIECTOMY; RATS; RATS, INBRED F344; SEX FACTORS; TOMOGRAPHY, SPIRAL COMPUTED; WEIGHTLESSNESS SIMULATION;

EID: 0242365768     PISSN: 00945765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0094-5765(02)00289-8     Document Type: Article

References (27)

1. D. Deever, R.S. Young, B. Bradshaw, M.L. Witten, Changes in organ perfusion and organ/body weight ratios in a simulated microgravity model, FASEB Journal 13 (1999) A406.
2. M.A. Frey, C.M. Tomaselli, W.G. Hoffler, Cardiovascular responses to postural changes: differences with age for women and men, Journal of Clinical Pharmacology 34 (1994) 394-402.
3. J.M. Fritsch-Yelle, J.B. Charles, M.M. Jones, L.A. Beightol, D.L. Eckberg, Spaceflight alters autonomic regulation of arterial pressure in humans, Journal of Applied Physiology 77 (1994) 1776-1783.
4. F.J. Baisch, G. Petrat, Body fluid distribution in man in space and effect of lower body negative pressure treatment, Clinical Investigations 71 (1993) 690-699.
5. R.L. Johnson, A.E. Nicogossian, S.A. Bergman Jr., G.W. Hoffler, Lower body negative pressure: the second manned Skylab mission, Aviation, Space, and Environmental Medicine 47 (1976) 347-353.
6. A.R. Hargens, Fluid shifts in vascular and extravascular spaces during and after simulated weightlessness, Medicine Science Sports Exercise 15 (1983) 421-427.
7. J. Draeger, R. Schwartz, S. Groenhoff, C. Stern, Self-tonometry under microgravity conditions, Aviation, Space, and Environmental Medicine 66 (1995) 568-570.
8. A.R. Hargens, C.M. Tipton, P.D. Gollnick, S.J. Mubarak, B.J. Tucker, W.H. Akeson, Fluid shifts and muscle function in humans during acute simulated microgravity, Journal of Applied Physiology 54 (1983) 1003-1009.
9. A. Guyton, J. Hall, Textbook of Medical Physiology, 9th Edition, W.B. Saunders Company, Philadelphia, PA, 1996, pp. 186-192.
10. W.G. Squires, M.L. Smith, T.A. Brandon, S.A. Zinkgraf, D.K. Rotto, D.M. Rotto, S.A. Nunneley, P.B. Raven, Hemodynamic responses to 6 degree head-down rest in dogs: effect of aerobic conditioning, Medicine Science Sports Exercise 23 (1991) 1020-1027.
11. J. Steskal, A.R. Hargens, E.R. Morey, Transient dehydration of lungs in tail-suspended rats, The Physiology 28 (1984) 314.
12. W.E. Thornton, T.P. Moore, S.L. Pool, J. Vanderploeg, Clinical characterization and etiology of space motion sickness, Aviation Space and Environmental Medicine 58 (1987) A1-A8.
13. L.D. Montgomery, Body volume changes during simulated microgravity I: technique and comparison of men and women during horizontal bed rest, Aviation Space and Environmental Medicine 64 (1993) 893-898.
14. C.M. Tipton, J.M. Overton, M.J. Joyner, A.R. Hargens, Local fluid shifts in humans and rats: comparison of simulation models with actual weightlessness, Physiology 30 (1987) S117-S120.
15. J.T. Bushberg, J.A. Seibert, E.M. Leidholdt Jr., J.M. Boone, The Essential Physics of Medical Imaging, Williams & Wilkins, Baltimore, 1994, pp. 239-290.
16. J.M. Nathan, B.A. Bradshaw, N. Bartoletti, M.L. Witten, Non-invasive measurement of organ density in a rat simulated microgravity model, Aviation, Space, and Environmental Medicine 71 (2000) 894-898.
17. F. Strollo, G. Riondino, B. Harris, G. Strollo, E. Casarosa, N. Mangrossa, C. Ferretti, M. Luisi, The effect of microgravity on testicular androgen secretion, Aviation Space and Environmental Medicine 69 (1998) 133-136.
18. W.M. Barron, J. Schreiber, M.D. Lindheimer, Effect of ovarian sex steroids on osmoregulation and vasopressin secretion in the rat, American Journal of Physiology (Endocrinology Metabolism) 13 (1986) E352-E361.
19. J.T. Crofton, P.G. Baer, L. Share, D.P. Brooks, Vasopressin release in male and female rats: effects of gonadectomy and treatment with gonadal steroid hormones, Endocrinology 117 (1985) 1195-1200.
20. R.S. Crowley, J.A. Amico, Gonadal steroid modulation of oxytocin and vasopressin gene expression in the hypothalamus of the osmotically stimulated rat, Endocrinology 133 (1993) 2711-2718.
21. K.A. Carlberg, M.J. Fregley, M. Fahey, Effects of chronic estrogen treatment on water exchange in rats, American Journal of Physiology (Endocrinology Metabolism) 10 (1984) E101-E110.
22. K. Myles, J.W. Funder, Progesterone binding to mineralocorticoid receptors: in vitro and vivo studies, American Journal of Physiology (Endocrinology Metabolism) 33 (1996) E601-E607.
23. Y. Zhang, K. Novak, S. Kaufman, Atrial natriuretic factor release during pregnancy in rats, Journal of Physiology 488 (1995) 509-514.
24. M.K. Mohamed, A.A. Abdel-Rahman, Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats, European Journal of Endocrinology 142 (2000) 307-314.
25. B.J. Tucker, C.A. Mundy, M.G. Ziegler, C. Baylis, R.C. Blantz, Head-down tilt and restraint on renal function and glomerular dynamics in the rat, Journal of Applied Physiology 63 (1987) 505-513.
26. M.B. Pamnani, Z. Mo, S. Chen, H.J. Bryant, R.J. White, F.J. Haddy, Effects of head-down tilt on hemodynamics, fluid volumes, and plasma Na-K pump inhibitor in rats, Aviation, Space, and Environmental Medicine 67 (1996) 928-934.
27. C. Pettis, R.S. Young, M. Drake, G. McNeill, J.N. Hall, E.J. Braun, K. Lindberg, M.L. Witten, Immediate changes in the kidney during simulated microgravity, Acta Astronautica 6 (2002) 393-398.