The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene

Gene

Volumn 318, Issue 1-2, 2003, Pages 177-184

  Cassuto, Hanoch ^a   Olswang, Yael ^a   Heinemann, Shmuel ^a   Sabbagh, Karen ^a   Hanson, Richard W ^b   Reshef, Lea ^a  

^a HEBREW UNIVERSITY   (Israel)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acidosis; Cell lines; Nuclear receptors; Transfection; Transgenic mice

Indexed keywords

ACCESSORY FACTOR 1; CELL NUCLEUS RECEPTOR; NUCLEAR FACTOR I; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN; UNCLASSIFIED DRUG;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL LINE; CONTROLLED STUDY; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; GENE MUTATION; GENETIC TRANSCRIPTION; KIDNEY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

MUS MUSCULUS;

EID: 0242348731     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(03)00775-3     Document Type: Article

References (30)

1. Botion L.M., Brito M.N., Brito N.A., Brito S.R.C., Kettelhut I.C., Migliorini R.H. Glucose contribution to in vivo synthesis of glyceride glycerol and fatty acids in rats adapted to high-protein, carbohydrate-free diet. Metabolism. 47:1998;1217-1221.
2. Cassuto H., Olswang Y., Livoff A.F., Nechushtan H., Hanson R.W., Reshef L. Involvement of HNF-1 in the regulation of phosphoenolpyruvate carboxykinase gene expression in the kidney. FEBS Lett. 412:1997;597-602.
3. Croniger C., Trus M., Lysek-Stupp K., Cohen H., Liu Y., Darlington G.J., Poli V., Hanson R.W., Reshef L. Role of the isoforms of C/EBP in the initiation of P-enolpyruvate carboxykinase (GTP) gene transcription at birth. J. Biol. Chem. 272:1997;26306-26312.
4. Curthoys N.P., Gstraunthaler G. Mechanism of increased renal gene expression during metabolic acidosis. Am. J. Physiol. Renal Physiol. 281:2001;F381-F390.
5. Djouadi F., Bastin J. PPARalpha gene expression in the developing rat kidney: role of glucocorticoids. J. Am. Soc. Nephrol. 12:2001;1197-1203.
6. Drewnowska K.D., Craig M.R., Digiovanni S.R., McCarty J.M., Moorman A.F., Lamers W.H., Schoolwerth A.C. PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis. J. Physiol. Pharmacol. 53:2002;3-20.
7. Eisenberger C.L., Nechushtan H., Cohen H., Shani M., Reshef L. Differential regulation of rat P-enolpyruvate carboxykinase gene expression in several tissues of transgenic mice. Mol. Cell. Biol. 12:1992;1396-1403.
8. Giguere V., Hollenberg S.M., Rosenfeld M.G., Evans R.M. Functional domains of the human glucocorticoid receptor. Cell. 46:1986;645-652.
9. Guan Y., Breyer M.D. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int. 60:2001;14-30.
10. Hanson R.W., Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem. 66:1997;581-611.
11. Hertz R., Bishara-Shieban J., Bar-Tana J. Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III. J. Biol. Chem. 270:1995;13470-13475.
12. Hertz R., Berman I., Keppler D., Bar-Tana J. Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome- proliferators-activated receptor (PPAR). Eur. J. Biochem. 235:1996;242-247.
13. Holcomb T., Liu W., Snyder R., Shapiro R., Curthoys N.P. Promoter elements that mediate the pH response of PCK mRNA in LLC-PK1-F+ cells. Am. J. Physiol. 271:1996;F340-F346.
14. Imai E., Stromstedt P.E., Quinn P.G., Carlstedt-Duke J., Gustafsson J.A., Granner D.K. Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 10:1990;4712-4719.
15. Mangelsdorf D.J., Ong E.S., Dyck J.A., Evans R.M. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature. 345:1990;224-229.
16. Meisner H., Loose D.S., Hanson R.W. Effects of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney. Biochemistry. 24:1985;421-425.
17. Olswang Y., Cohen H., Papo O., Cassuto H., Croniger C.M., Hakimi P., Tilghman S.M., Hanson R., Reshef L. A mutation in the peroxisome proliferator-activated receptor gamma -binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice. Proc. Natl. Acad. Sci. U. S. A. 99:2002;625-630.
18. Owen O.E., Patel M.S., Block B.S.B., Kreulen T.H., Reichle F.A., Mozzoli M.A. Gluconeogenesis in normal, cirrhotic, and diabetic humans. Hanson R.W., Mehlman M.A. Gluconeogenesis, Its Regulation in Mammalian Species. 1976;533-558 Wiley-Intersciences, New York.
19. Patel Y.M., Yun J.S., Liu J., McGrane M.M., Hanson R.W. An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice. J. Biol. Chem. 269:1994;5619-5628.
20. Pontoglio M., Barra J., Hadchouel D., Kress C., Bach J.P., Babinet C., Yaniv M. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell. 84:1996;575-585.
21. Ruppert S., Boshart M., Bosch F.X., Schmid W., Fournier R.E.K., Schutz G. Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell. 61:1990;895-904.
22. Sladek F.M., Zhong W.M., Lai E., Darnell J.E.J. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:1990;2353-2365.
23. Soutoglou E., Viollet B., Vaxillaire M., Yaniv M., Pontoglio M., Talianidis I. Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity. EMBO J. 20:2001;1984-1992.
24. Stafford J.M., Wilkinson J.C., Beechem J.M., Granner D.K. Accessory factors facilitate the binding of glucocorticoid receptor to the PEPCK gene promoter. J. Biol. Chem. 276:2001;39885-39891.
25. Streeper R.S., Svitek C.A., Goldman J.K., O'Brien R.M. Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines. J. Biol. Chem. 275:2000;12108-12118.
26. Sugden M.C., Bulmer K., Gibbons G.F., Holness M.J. Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding. Arch. Biochem. Biophys. 395:2001;246-252.
27. Sugiyama T., Scott D.K., Wang J.C., Granner D.K. Structural requirements of the glucocorticoid and retinoic acid response units in the phosphoenolpyruvate carboxykinase gene promoter. Mol. Endocrinol. 12:1998;1487-1498.
28. Tontonoz P., Hu E., devine J., Beale E.G., Spiegelman B.M. PPARg2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15:1995;351-357.
29. Viollet B., Yaniv M., Pontoglio M. Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes. Mol. Cell. Biol. 21:2001;3662-3670.
30. Yanuka-Kashles O., Cohen H., Trus M., Aran A., Benvenisty N., Reshef L. Transcriptional regulation of the phosphoenolpyruvate carboxykinase (GTP) gene by cooperation between hepatic nuclear factors. Mol. Cell. Biol. 14:1994;7124-7133.