Coexpression of carcinoembryonic antigen and E-cadherin in colorectal adenocarcinoma with liver metastasis

Journal of Gastrointestinal Surgery

Volumn 7, Issue 7, 2003, Pages 931-938

  Kim, Jin C ^a   Roh, Seon A ^a   Kim, Hee C ^a   Koo, Kum H ^a   Cho, Young K ^a   Yu, Chang S ^a   Kwon, Young M ^a   Kim, Jung S ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

CEA; Colorectal cancer; E cadherin; Liver metastasis; mRNA

Indexed keywords

BIOTIN; CARCINOEMBRYONIC ANTIGEN; MESSENGER RNA; STREPTAVIDIN; UVOMORULIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER METASTASIS; MALE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0242334050     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gassur.2003.07.001     Document Type: Article

References (37)

1. Buras R.R., Beatty B.G., Williams L.E., Wanek P.M., Harris J.B., Hill L.R., Beatty J.D. Radioimmunotherapy of human colon cancer in nude mice. Arch Surg. 125:1990;660-664.
2. Dorudi S., Sheffield J.P., Poulsom R., Northover J.M., Hart I.R. E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol. 142:1993;981-986.
3. Nigam A.K., Savage F.J., Boulos P.B., Stamp G.W., Liu D., Pignatelli M. Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. Br J Cancer. 68:1993;507-514.
4. Benchimol S., Fuks A., Jothy S., Beauchemin N., Shirota K., Stanners C.P. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell. 57:1989;327-334.
5. Pignatelli M., Durbin H., Bodmer W.F. Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions. Proc Natl Acad Sci USA. 87:1990;1541-1545.
6. Obrink B. CEA adhesion molecules: Multifunctional proteins with signal regulatory properties. Curr Opin Cell Biol. 9:1997;171-177.
7. von Kleist S., Migule I., Halla B. Possible function of CEA as cell-contact inhibitory molecule. Anticancer Res. 15:1995;1889-1894.
8. Bracke M.E., van Roy F.M., Mareel M.M. The E-cadherin complex in invasion and metastasis. Gunthert I.U., Birchmeier W. Attempts to Understand Metastasis Function. 1996;132-161 Springer, Berlin.
9. Takeichi M. Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol. 5:1993;806-811.
10. Birchmeier W., Behrens J. Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta. 1198:1994;11-26.
11. Kim J.C., Han M.S., Lee H.K., Kim W.S., Park S.K., Park K.C., Bodmer W.F., Rowan A.J., Kim O.J. Distribution of carcinoembryonic antigen and biologic behavior in colorectal carcinoma. Dis Colon Rectum. 42:1999;640-648.
12. El-Bahrawy M.A., Poulsom R., Jeffery R., Talbot I., Alison M.R. The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol. 32:2001;1216-1224.
13. Mareel M., Bracke M., Van Roy F. Cancer metastasis: Negative regulation by an invasion-suppressor complex. Cancer Detect Prev. 19:1995;451-464.
14. Hauck W., Stanner C.P. Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors. J Biol Chem. 70:1995;3602-3610.
15. Kanazawa T., Watanabe T., Kazama S., Tada T., Koketsu S., Nagawa H. Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region. Int J Cancer. 102:2002;225-229.
16. Bjerner J., Lebedin Y., Bellanger L., Kuroki M., Shively J.E., Varaas T., Nustad K., Hammarstrom S., Bormer O.P. Protein epitopes in carcinoembryonic antigen. Report of the ISOBM TD8 workshop. Tumour Biol. 23:2002;249-262.
17. Barnett T., Goebel S.J., Nothdurft M.A., Elting J.J. Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. Genomics. 3:1988;59-66.
18. Berx G., Cleton-Jansen A.M., Nollet F., de Leeuw W.J., van de Vijver M., Cornelisse C., van Roy F. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J. 14:1995;6107-6115.
19. Frängsmyr L., Baranov V., Hammarström S. Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat. Tumor Biol. 20:1999;277-292.
20. Buxton R.S., Magee A.I. Structure and interactions of desmosomal and other cadherins. Semin. Cell Biol. 3:1992;157-167.
21. Thomas P., Gangopadhyay A., Steele G. Jr., Andrews C., Nakazato H., Oikawa S., Jessup J.M. The effect of transfection of the CEA gene on the metastatic behavior of the human colorectal cancer cell line MIP-101. Cancer Lett. 92:1995;59-66.
22. Hashino J., Fukuda Y., Oikawa S., Nakazato H., Nakanishi T. Metastatic potential of human colorectal carcinoma SW1222 cells transfected with cDNA encoding carcinoembryonic antigen. Clin Exp Metastasis. 12:1994;324-328.
23. Mbalaviele G., Dunstan C.R., Sasaki A., Williams P.J., Mundy G.R., Yoneda T. E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res. 56:1996;4063-4070.
24. Byers S.W., Sommers C.L., Hoxter B., Mercurio A.M., Tozeren A. Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength. J Cell Sci. 108:1995;2053-2064.
25. Grimm T., Johnson J.P. Ectopic expression of carcinoembryonic antigen by a melanoma cell leads to changes in the transcription of two additional cell adhesion molecules. Cancer Res. 55:1995;3254-3257.
26. Kanai T., Watanabe M., Hayashi A., Nakazawa A., Okazawa A., Yamazaki M., Ishii H., Hibi T. Regulatory effect of interleukin-4 and interleukin-13 on colon cancer cell adhesion. Br J Cancer. 82:2000;1717-1723.
27. Chan A.O., Lam S.K., Chu K.M., Lam C.M., Kwok E., Leung S.Y., Yuen S.T., Law S.Y., Hui W.M., Lai K.C., Wong C.Y., Hu H.C., Lai C.L., Wong J. Soluble E-cadherin is a valid prognostic marker in gastric carcinoma. Gut. 48:2001;808-811.
28. Boucher D., Cournoyer D., Stanners C.P., Fuks A. Studies on the control of gene expression of the carcinoembryonic antigen family in human tissue. Cancer Res. 49:1989;847-852.
29. Tran R., Kashmiri S.V., Kantor J., Greiner J.W., Pestka S., Shively J.E., Schlom J. Correlation of DNA hypomethylation with expression of carcinoembryonic antigen in human colon carcinoma cells. Cancer Res. 20:1988;5674-5679.
30. Cao G., Kuriyama S., Gao J., Mitoro A., Cui L., Nakatani T., Zhang X., Kikukawa M., Pan X., Fukui H., Qi Z. Comparison of carcinoembryonic antigen promoter regions isolated from human colorectal carcinoma and normal adjacent mucosa to induce strong tumor-selective gene expression. Int J Cancer. 78:1998;242-247.
31. Berx G., Staes K., van Hengel J., Molemans F., Bussemakers M.J., van Bokhoven A., van Roy F. Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). Genomics. 26:1995;281-289.
32. Kim J.C., Gong G., Roh S.A., Park K.C. Carcinoembryonic antigen gene and carcinoembryonic antigen expression in the liver metastasis of colorectal carcinoma. Mol Cells. 9:1999;133-137.
33. Jessup J.M., Petrick A.T., Toth C.A., Ford R., Meterissian S., O'Hara C.J., Steele G. Jr., Thomas P. Carcinoembryonic antigen: enhancement of liver colonisation through retention of human colorectal carcinoma cells. Br J Cancer. 67:1993;464-470.
34. Pocard M., Debruyne P., Bras-Goncalves R., Mareel M., Dutrillaux B., Poupon M.F. Single alteration of p53 or E-cadherin genes can alter the surgical resection benefit in an experimental model of colon cancer. Dis Colon Rectum. 44:2001;1106-1112.
35. Chu D.Z., Erickson C.A., Russell M.P., Thompson C., Lang N.P., Broadwater R.J., Westbrook K.C. Prognostic significance of carcinoembryonic antigen in colorectal carcinoma. Serum levels before and after resection and before recurrence. Arch Surg. 126:1991;314-316.
36. Nanashima A., Yamaguchim H., Sawaim T., Yamaguchim E., Kidogawa H., Matsuo S., Yasutake T., Tsuji T., Jibiki M., Nakagoe T., Ayabe H. Prognostic factors in hepatic metastases of colorectal carcinoma. Dig Dis Sci. 46:2001;1623-1628.
37. Wiggers T., Arends J.W., Verstijnen C., Moerkerk P.M., Bosman F.T. Prognostic significance of CEA immunoreactivity patterns in large bowel carcinoma tissue. Br J Cancer. 54:1986;409-414.