Decision Analysis of Antibiotic and Diagnostic Strategies in Ventilator-associated Pneumonia

American Journal of Respiratory and Critical Care Medicine

Volumn 168, Issue 9, 2003, Pages 1060-1067

  Ost, David E ^a   Hall, Charles S ^b   Joseph, Gnanaraj ^b   Ginocchio, Christine ^b   Condon, Susan ^b   Kao, Emily ^b   LaRusso, Michele ^b   Itzla, Richard ^b   Fein, Alan M ^b  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b NONE

Author keywords

Bronchoscopy; Decision analysis; Evidence based medicine; Ventilator associated pneumonia

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; BRONCHOSCOPY; COST EFFECTIVENESS ANALYSIS; DECISION MAKING; DIAGNOSTIC TEST; EVIDENCE BASED MEDICINE; HUMAN; LUNG LAVAGE; PNEUMONIA; PRIORITY JOURNAL; SURVIVAL; TRACHEOBRONCHIAL TOILET; TREATMENT OUTCOME; VENTILATOR ASSOCIATED PNEUMONIA;

ANTI-BACTERIAL AGENTS; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; COSTS AND COST ANALYSIS; DECISION SUPPORT TECHNIQUES; DRUG THERAPY, COMBINATION; HUMANS; INTUBATION, INTRATRACHEAL; PNEUMONIA, BACTERIAL; RESPIRATION, ARTIFICIAL; SOFTWARE; SURVIVAL ANALYSIS;

EID: 0242333196     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200302-199OC     Document Type: Article

References (58)

1. Haley RW, Culver DH, White JW, Morgan WM, Emori TG. The nationwide nosocomial infection rate: a new need for vital statistics. Am J Epidemiol 1985;121:159-167.
2. Pennington JE. Nosocomial respiratory infections. In: Mandell GL, Douglas RG, Bennet JE, editors. Principles and practice of infectious diseases. St. Louis: Churchill Livingstone; 1990. p. 2199-2205.
3. Monitoring hospital-acquired infections to promote patient safety-United States, 1990-1999. MMWR Morb Mortal Wkly Rep 2000;49: 149-153.
4. Celis R, Torres A, Gatell JM, Almela M, Rodriguez-Roisin R, Agusti-Vidal A. Nosocomial pneumonia: a multivariate analysis of risk and prognosis. Chest 1988;93:318-324.
5. National Nosocomial Infections Surveillance (NNIS) System report, data summary from January 1990-May 1999, issued June 1999. Am J Infect Control 1999;27:520-532.
6. Fagon JY, Chastre J, Domart Y, Trouillet JL, Pierre J, Darne C, Gibert C. Nosocomial pneumonia in patients receiving continuous mechanical ventilation: prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques. Am Rev Respir Dis 1989;139:877-884.
7. Torres A, Aznar R, Gatell JM, Jimenez P, Gonzalez J, Ferrer A, Celis R, Rodriguez-Roisin R. Incidence, risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis 1990;142:523-528.
8. Craven DE, Kunches LM, Kilinsky V, Lichtenberg DA, Make BJ, McCabe WR. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 1986; 133:792-796.
9. Markowicz P, Wolff M, Djedaini K, Cohen Y, Chastre J, Delclaux C, Merrer J, Herman B, Veber B, Fontaine A, et al. Multicenter prospective study of ventilator-associated pneumonia during acute respiratory distress syndrome: incidence, prognosis, and risk factors: ARDS Study Group. Am J Respir Crit Care Med 2000;161:1942-1948.
10. Rello J, Ausina V, Ricart M, Castella J, Prats G. Impact of previous antimicrobial therapy on the etiology and outcome of ventilator-associated pneumonia. Chest 1993;104:1230-1235.
11. Rello J, Rue M, Jubert P, Muses G, Sonora R, Valles J, Niederman MS. Survival in patients with nosocomial pneumonia: impact of the severity of illness and the etiologic agent. Crit Care Med 1997;25:1862-1867.
12. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 1999;115:462-474.
13. Luna CM, Vujacich P, Niederman MS, Vay C, Gherardi C, Matera J, Jolly EC. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997;111:676-685.
14. Alvarez-Lerma F. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit: ICU-Acquired Pneumonia Study Group. Intensive Care Med 1996;22:387-394.
15. Kollef MH, Bock KR, Richards RD, Hearns ML. The safety and diagnostic accuracy of minibronchoalveolar lavage in patients with suspected ventilator-associated pneumonia. Ann Intern Med 1995;122:743-748.
16. Rello J, Gallego M, Mariscal D, Sonora R, Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 1997;156:196-200.
17. Sanchez-Nieto JM, Torres A, Garcia-Cordoba F, El-Ebiary M, Carrillo A, Ruiz J, Nunez ML, Niederman M. Impact of invasive and noninvasive quantitative culture sampling on outcome of ventilator-associated pneumonia: a pilot study. Am J Respir Crit Care Med 1998;157:371-376.
18. Ruiz M, Torres A, Ewig S, Marcos MA, Alcon A, Lledo R. Asenjo MA, Maldonaldo A. Noninvasive versus invasive microbial investigation in ventilator-associated pneumonia: evaluation of outcome. Am J Respir Crit Care Med 2000;162:119-125.
19. Dupont H, Mentec H, Sollet JP, Bleichner G. Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 2001;27:355-362.
20. Sole Violan J, Fernandez JA, Benitez AB, Cardenosa Cendrero JA, Rodriguez de Castro F. Impact of quantitative invasive diagnostic techniques in the management and outcome of mechanically ventilated patients with suspected pneumonia. Crit Care Med 2000;28:2737-2741.
21. Heyland DK, Cook DJ, Griffith L, Keenan SP, Brun-Buisson C. The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient: the Canadian Critical Trials Group. Am J Respir Crit Care Med 1999;159:1249-1256.
22. Fagon JY, Chastre J, Wolff M, Gervais C, Parer-Aubas S, Stephan F, Similowski T, Mercat A, Diehl JL, Sollet JP, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial. Ann Intern Med 2000;132:621-630.
23. Trouillet JL, Chastre J, Vuagnat A, Joly-Guillou ML, Combaux D, Dombret MC, Gibert C. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998; 157:531-539.
24. Hanberger H, Garcia-Rodriguez JA, Gobernado M, Goossens H, Nilsson LE, Struelens MJ. Antibiotic susceptibility among aerobic gramnegative bacilli in intensive care units in 5 European countries: French and Portuguese ICU Study Groups. JAMA 1999;281:67-71.
25. Itokazu GS, Quinn JP, Bell-Dixon C, Kahan FM, Weinstein RA. Antimicrobial resistance rates among aerobic gram-negative bacilli recovered from patients in intensive care units: evaluation of a national postmarketing surveillance program. Clin Infect Dis 1996;23:779-784.
26. Bergogne-Berezin E. Treatment and prevention of nosocomial pneumonia. Chest 1995;108:265-345.
27. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002;122:262-268.
28. Heyland DK, Cook DJ, Marshall J, Heule M, Guslits B, Lang J, Jaeschke R. The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia: Canadian Critical Care Trials Group. Chest 1999;115:1076-1084.
29. Croce MA, Fabian TC, Shaw B, Stewart RM, Pritchard FE, Minard G, Kudsk KA, Baselski VS. Analysis of charges associated with diagnosis of nosocomiai pneumonia: can routine bronchoscopy be justified? J Trauma 1994;37:721-727.
30. Fowler RA, Flavin KE, Barr J, Weinacker AB, Parsonnet J, Gould MK. Variability in antibiotic prescribing patterns and outcomes in patients with clinically suspected ventilator-associated pneumonia. Chest 2003; 123:835-844.
31. Hospital-acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy, and preventive strategies: a consensus statement, American Thoracic Society, November 1995. Am J Respir Crit Care Med 1996;153:1711-1725.
32. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002;165:867-903.
33. Singh N, Rogers P, Atwood CW, Wagener MM, Yu VL. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit: a proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 2000;162:505-511.
34. Paladino JA, Fell RE. Pharmacoeconomic analysis of cefmenoxime dual individualization in the treatment of nosocomial pneumonia. Ann Pharmacother 1994;28:384-389.
35. Paladino JA. Cost-effectiveness comparison of cefepime and ceftazidime using decision analysis. Pharmacoeconomics 1994;5:505-512.
36. McNabb JJ, Nightingale CH, Quintiliani R, Nicolau DP. Cost-effectiveness of ceftazidime by continuous infusion versus intermittent infusion for nosocomial pneumonia. Pharmacotherapy 2001;21:549-555.
37. Rello J, Sa-Borges M, Correa H, Leal SR, Baraibar J. Variations in etiology of ventilator-associated pneumonia across four treatment sites: implications for antimicrobial prescribing practices. Am J Respir Crit Care Med 1999;160:608-613.
38. Sterling TR, Ho EJ, Brehm WT, Kirkpatrick MB. Diagnosis and treatment of ventilator-associated pneumonia-impact on survival: a decision analysis. Chest 1996;110:1025-1034.
39. Baker AM, Bowton DL, Haponik EF. Decision making in nosocomial pneumonia: an analytic approach to the interpretation of quantitative bronchoscopic cultures. Chest 1995;107:85-95.
40. Torres A, el-Ebiary M. Invasive diagnostic techniques for pneumonia: protected specimen brush, bronchoalveolar lavage, and lung biopsy methods. Infect Dis Clin North Am 1998;12:701-722.
41. Bonten MJ, Bergmans DC, Stobberingh EE, van der Geest S, De Leeuw PW, van Tiel FH, Gaillard CA. Implementation of bronchoscopic techniques in the diagnosis of ventilator-associated pneumonia to reduce antibiotic use. Am J Respir Crit Care Med 1997;156:1820-1824.
42. Ibrahim EH, Ward S, Sherman G, Schaiff R, Fraser VJ, Kollef MH. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med 2001;29:1109-1115.
43. Michaud S, Suzuki S, Harbarth S. Effect of design-related bias in studies of diagnostic tests for ventilator-associated pneumonia. Am J Respir Crit Care Med 2002;166:1320-1325.
44. Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 1993;94:281-288.
45. Leroy O, Guilley J, Georges H, Choisy P, Guery B, Alfandari S, Beaucaire G. Effect of hospital-acquired ventilator-associated pneumonia on mortality of severe community-acquired pneumonia. J Crit Care 1999;14:12-19.
46. Rello J, Quintana E, Ausina V, Castella J, Luquin M, Net A, Prats G. Incidence, etiology, and outcome of nosocomial pneumonia in mechanically ventilated patients. Chest 1991;100:439-444.
47. Kollef MH, Silver P, Murphy DM, Trovillion E. The effect of late-onset ventilator-associated pneumonia in determining patient mortality. Chest 1995;108:1655-1662.
48. Baker AM, Meredith JW, Haponik EF. Pneumonia in intubated trauma patients: microbiology and outcomes. Am J Respir Crit Care Med 1996; 153:343-349.
49. Kollef MH. Ventilator-associated pneumonia: a multivariate analysis. JAMA 1993;270:1965-1970.
50. Ibrahim EH, Tracy L, Hill C, Fraser VJ, Kollef MH. The occurrence of ventilator-associated pneumonia in a community hospital: risk factors and clinical outcomes. Chest 2001;120:555-561.
51. Kollef MH, Ward S. The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest 1998;113:412-420.
52. Grossman RF, Fein A. Evidence-based assessment of diagnostic tests for ventilator-associated pneumonia: executive summary. Chest 2000;117: 177S-181S.
53. Torres A, El-Ebiary M. Bronchoscopic BAL in the diagnosis of ventilator-associated pneumonia. Chest 2000;117:198S-202S.
54. Baughman RP. Protected-specimen brush technique in the diagnosis of ventilator-associated pneumonia. Chest 2000;117:203S-206S.
55. Niederman MS. Bronchoscopy in nonresolving nosocomial pneumonia. Chest 2000;117:212S-218S.
56. Cook D, Mandell L. Endotracheal aspiration in the diagnosis of ventilator-associated pneumonia. Chest 2000;117:195S-197S.
57. Campbell GD Jr. Blinded invasive diagnostic procedures in ventilator-associated pneumonia. Chest 2000;117:207S-211S.
58. Detsky AS, Naglie G, Krahn MD, Redelmeier DA, Naimark D. Primer on medical decision analysis: II: building a tree. Med Decis Making 1997;17:126-135.