G541R within the 4070A TM Protein Regulates Fusion in Murine Leukemia Viruses

Journal of Virology

Volumn 77, Issue 22, 2003, Pages 12011-12021

  O'Reilly, Lucille ^a   Roth, Monica J ^a,b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; MEMBRANE PROTEIN; SULFUR 35; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CYTOPATHOGENIC EFFECT; GENETIC TRANSFECTION; ISOTOPE LABELING; LEUKEMIA VIRUS; MEMBRANE FUSION; MURINE LEUKEMIA VIRUS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS ENVELOPE; VIRUS REPLICATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; DOGS; LEUKEMIA VIRUS, MURINE; MEMBRANE FUSION; MICE; NIH 3T3 CELLS; POINT MUTATION; RATS; RETROVIRIDAE PROTEINS, ONCOGENIC; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL ENVELOPE PROTEINS;

EID: 0242331739     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.22.12011-12021.2003     Document Type: Article

References (48)

1. Bachrach, E., M. Marin, M. Pelegrin, G. Karavanas, and M. Piechaczyk. 2000. Efficient cell infection by Moloney murine leukemia virus-derived particles requires minimal amounts of envelope glycoprotein. J. Virol. 74: 8480-8486.
2. Bae, Y., S. M. Kingsman, and A. J. Kingsman. 1997. Functional dissection of the Moloney murine leukemia virus envelope protein gp70. J. Virol. 71: 2092-2099.
3. Barnett, A. L., R. A. Davey, and J. M. Cunningham. 2001. Modular organization of the Friend murine leukemia virus envelope protein underlies the mechanism of infection. Proc. Natl. Acad. Sci. USA 98:4113-4118.
4. Barnett, A. L., D. L. Wensel, W. Li, D. Fass, and J. M. Cunningham. 2003. Structure and mechanism of a coreceptor for infection by a pathogenic feline retrovirus. J. Virol. 77:2717-2729.
5. Burkhart, M. D., S. C. Kayman, Y. He, and A. Pinter. 2003. Distinct mechanisms of neutralization by monoclonal antibodies specific for sites in the N-terminal or C-terminal domain of murine leukemia virus SU. J. Virol. 77:3993-4003.
6. Burns, C. C., M. L. Poss, E. Thomas, and J. Overbaugh. 1995. Mutations within a putative cysteine loop of the transmembrane protein of an attenuated immunodeficiency-inducing feline leukemia virus variant inhibit envelope protein processing. J. Virol. 69:2126-2132.
7. Chung, M., K. Kizhatil, L. M. Albritton, and G. N. Gaulton. 1999. Induction of syncytia by neuropathogenic murine leukemia viruses depends on receptor density, host cell determinants, and the intrinsic fusion potential of envelope protein. J. Virol. 73:9377-9385.
8. Clague, M. J., C. Schoch, and R. Blumenthal. 1991. Delay time for influenza virus hemagglutinin-induced membrane fusion depends on hemagglutinin surface density. J. Virol. 65:2402-2407.
9. Danieli, T., S. L. Pelletier, Y. I. Henis, and J. M. White. 1996. Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers. J. Cell Biol. 133:559-569.
10. Davey, R. A., Y. Zuo, and J. M. Cunningham. 1999. Identification of a receptor-binding pocket on the envelope protein of Friend murine leukemia virus. J. Virol. 73:3758-3763.
11. Evans, L. H., R. P. Morrison, F. G. Malik, J. Portis, and W. J. Britt. 1990. A neutralizable epitope common to the envelope glycoproteins of ecotropic, polytropic, xenotropic, and amphotropic murine leukemia viruses. J. Virol. 64:6176-6183.
12. Fass, D., S. C. Harrison, and P. S. Kim. 1996. Retrovirus envelope domain at 1.7 Å resolution. Nat. Struct. Biol. 3:465-468.
13. Felkner, R. H., and M. J. Roth. 1992. Mutational analysis of the N-linked glycosylation sites of the SU envelope protein of Moloney murine leukemia virus. J. Virol. 66:4258-4264.
14. Gray, K. D., and M. Roth. 1993. Mutational analysis of the envelope gene of Moloney murine leukemia virus. J. Virol. 67:3489-3496.
15. Kuhmann, S. E., E. J. Platt, S. L. Kozak, and D. Kabat. 2000. Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1. J. Virol. 74:7005-7015.
16. Lavillette, D., B. Boson, S. J. Russell, and F.-L. Cosset. 2001. Activation of membrane fusion by murine leukemia viruses is controlled in cis or in trans by interactions between the receptor-binding domain and a conserved disulfide loop of the carboxy terminus of the surface glycoprotein. J. Virol. 75:3685-3695.
17. Lavillette, D., M. Maurice, C. Roche, S. Russell, M. Sitbon, and F.-L. Cosset. 1998. A proline-rich motif downstream of the receptor binding domain modulates conformation and fusogenicity of murine retroviral envelopes. J. Virol. 72:9955-9965.
18. Lavillette, D., A. Ruggieri, B. Boson, M. Maurice, and F. L. Cosset. 2002. Relationship between SU subdomains that regulate the receptor-mediated transition from the native (fusion-inhibited) to the fusion-active conformation of the murine leukemia virus glycoprotein. J. Virol. 76:9673-9685.
19. Lavillette, D., A. Ruggieri, S. J. Russell, and F.-L. Cosset. 2000. Activation of a cell entry pathway common to type C mammalian retroviruses by soluble envelope fragments. J. Virol. 74:295-304.
20. Lineberger, J. E., R. Danzeisen, D. J. Hazuda, A. J. Simon, and M. D. Miller. 2002. Altering expression levels of human immunodeficiency virus type 1 gp120-gp41 affects efficiency but not kinetics of cell-cell fusion. J. Virol. 76:3522-3533.
21. Lu, C.-W., L. O'Reilly, and M. J. Roth. 2003. G100R mutation within 4070A murine leukemia virus Env increases virus receptor binding, kinetics of entry, and viral transduction efficiency. J. Virol. 77:739-743.
22. Lu, C.-W., and M. J. Roth. 2001. Functional characterization of the N termini of murine leukemia virus envelope protein. J. Virol. 75:4357-4366.
23. Lu, C.-W., and M. J. Roth. 2002. Functional interaction between the N- and C-terminal domains of murine leukemia virus surface envelope protein. Virology 310:131-141.
24. Macdonald, C., S. Walker, M. Watts, S. Ings, D. C. Linch, and S. Devereux. 2000. Effects of changes in expression of the amphotropic retroviral receptor PiT-2 on transduction efficiency and virus titer: implications for gene therapy. Hum. Gene Ther. 11:587-595.
25. Maerz, A. L., R. J. Center, B. E. Kemp, B. Kobe, and P. Poumbourios. 2000. Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure. J. Virol. 74:6614-6621.
26. Maerz, A. L., H. E. Drummer, K. A. Wilson, and P. Poumbourios. 2001. Functional analysis of the disulfide-bonded loop/chain reversal region of human immunodeficiency virus type 1 gp41 reveals a critical role in gp120/ gp41 association. J. Virol. 75:6635-6644.
27. McClure, M. O., M. A. Sommerfelt, M. Marsh, and R. A. Weiss. 1990. The pH independence of mammalian retrovirus infection. J. Gen. Virol. 71:767-773.
28. O'Reilly, L., and M. J. Roth. 2003. Identification of conformational and cold-sensitive mutations in the MuLV Env. Virology 312:337-349.
29. O'Reilly, L., and M. J. Roth. 2000. Second-site changes affect viability of amphotropic/ecotropic chimeric enveloped murine leukemia viruses. J. Virol. 74:899-913.
30. Park, B. H., B. Matuschke, E. Lavi, and G. N. Gaulton. 1994. A point mutation in env gene of murine leukemia virus induces syncytium formation and neurologic disease. J. Virol. 68:7516-7524.
31. Peredo, C., L. O'Reilly, K. Gray, and M. J. Roth. 1996. Characterization of chimeras between the ecotropic Moloney murine leukemia virus and the amphotropic 4070A envelope proteins. J. Virol. 70:3142-3152.
32. Persson, R., C. Wohlfart, U. Svensson, and E. Everitt. 1985. Virus-receptor interaction in the adenovirus system: characterization of the positive cooperative binding of virions on HeLa cells. J. Virol. 54:92-97.
33. Pinter, A., and E. Fleissner. 1977. The presence of disulfide-linked gp70-p15(E) complexes in AKR murine leukemia virus. Virology 83:417-422.
34. Pinter, A., W. J. Honnen, J.-S. Tung, P. V. O'Donnell, and U. Hammerling. 1982. Structural domains of endogenous murine leukemia virus gp70s containing specific antigenic determinants defined by monoclonal antibodies. Virology 116:499-516.
35. Pinter, A., R. Kopelman, Z. Li, S. C. Kayman, and D. A. Sanders. 1997. Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes. J. Virol. 71:8073-8077.
36. Pinter, A., J. Lieman-Hurwitz, and E. Fleissner. 1978. The nature of the association between the murine leukemia virus envelope proteins. Virology 91:345-351.
37. Platt, E. J., K. Wehrly, S. E. Kuhmann, B. Chesebro, and D. Kabat. 1998. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J. Virol. 72:2855-2864.
38. Ragheb, J. A., H. Yu, T. Hoffman, and W. F. Anderson. 1995. The amphotropic and ecotropic murine leukemia virus envelope TM subunits are equivalent mediators of direct membrane fusion: implications for the role of ecotropic envelope and receptor in syncytium formation and viral entry. J. Virol. 69:7205-7215.
39. Rein, A., J. Mirro, J. G. Haynes, S. M. Ernst, and K. Nagashima. 1994. Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein. J. Virol. 68:1773-1781.
40. Rothenberg, S. M., M. N. Olsen, L. C. Laurent, R. A. Crowley, and P. O. Brown. 2001. Comprehensive mutational analysis of the Moloney murine leukemia virus envelope protein. J. Virol. 75:11851-11862.
41. Rowe, W. P., W. E. Pugh, and J. W. Hartley. 1970. Plaque assay techniques for murine leukemia viruses. Virology 42:1136-1139.
42. Sanders, D. A. 2000. Sulfhydryl involvement in fusion mechanisms. Subcell. Biochem. 34:483-514.
43. Sommerfelt, M. A., and R. A. Weiss. 1990. Receptor interference groups of 20 retroviruses plating on human cells. Virology 176:58-69.
44. Soneoka, Y., P. M. Cannon, E. E. Ramsdale, J. C. Griffiths, G. Romano, M. S., Kingsman, and A. J. Kingsman. 1995. A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res. 23:629-633.
45. Thomas, A., K. D. Gray, and M. J. Roth. 1997. Analysis of mutations within the cytoplasmic domain of the Moloney murine leukemia virus transmembrane protein. Virology 227:305-313.
46. Wu, B. W., P. M. Cannon, E. M. Gordon, F. L. Hall, and W. F. Anderson. 1998. Characterization of the proline-rich region of murine leukemia virus envelope protein. J. Virol. 72:5383-5391.
47. Yu, E. W., and D. E. Koshland. 2001. Propagating conformational changes over long (and short) distances in proteins. Proc. Natl. Acad. Sci. USA 98:9517-9520.
48. Zavorotinskaya, T., and L. M. Albritton. 1999. Suppression of a fusion defect by second site mutations in the ecotropic murine leukemia virus surface protein. J. Virol. 73:5034-5042.