Functional analysis of the disulfide-bonded loop/chain reversal region of human immunodeficiency virus type 1 gp41 reveals a critical role in gp120-gp41 association

Journal of Virology

Volumn 75, Issue 14, 2001, Pages 6635-6644

  Maerz, A L ^a   Drummer, H E ^a   Wilson, K A ^a   Poumbourios, P ^a  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; VIRUS ENVELOPE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FUSION; CELL SURFACE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISULFIDE BOND; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 1; MEMBRANE FUSION; MURINE LEUKEMIA VIRUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; VIRUS ADSORPTION; VIRUS ENVELOPE;

AMINO ACID SEQUENCE; CELL LINE; CELL MEMBRANE; DISULFIDES; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034984522     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.14.6635-6644.2001     Document Type: Article

References (61)

1. Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodies
2. CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
3. Structural basis for paramyxovirus-mediated membrane fusion
4. A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure
5. Structure of influenza haemagglutinin at the pH of membrane fusion
6. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41
7. Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein
8. Changes in the cytopathic effects of human immunodeficiency virus type 1 associated with a single amino acid alteration in the ectodomain of the gp41 transmembrane glycoprotein
9. A spring-loaded mechanism for the conformational change of influenza hemagglutinin
10. Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target
11. Core structure of gp41 from the HIV envelope glycoprotein
12. HIV entry and its inhibition
13. Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation
14. 2 subunit to form an N cap that terminates the triple-stranded coiled coil
15. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
16. Receptor-triggered membrane association of a model retroviral glycoprotein
17. Identification of a major co-receptor for primary isolates of HIV-1
18. + cells is mediated by the chemokine receptor CC-CKR-5
19. Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein
20. Retrovirus envelope domain at 1.7 Å resolution
21. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
22. Capture of an early fusion-active conformation of HIV-1 gp41
23. Generation of human monoclonal antibodies to human immunodeficiency virus
24. Recognition by human monoclonal antibodies of free and complexed peptides representing the prefusogenic and fusogenic forms of human immunodeficiency virus type 1 gp41
25. 131I-labelled human growth hormone of high specific radioactivity
26. The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells
27. Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein
28. Activation of a retroviral membrane fusion protein: Soluble receptor-induced liposome binding of the ALSV envelope glycoprotein
29. Conformational changes in cell surface HIV-1 envelope glycoproteins are triggered by cooperation between cell surface CD4 and co-receptors
30. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry
31. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
32. Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins
33. A trimeric structural domain of the HIV-1 transmembrane glycoprotein
34. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
35. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: A new member of the immunoglobulin gene family
36. Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure
37. Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: Conserved helical interactions underlie the broad inhibitory activity of gp41 peptides
38. Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution
39. Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus
40. Variable constraints on the principal immunodominant domain of the transmembrane glycoprotein of human immunodeficiency virus type 1
41. New mammalian expression vectors
42. Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes
43. Evolutionary conservation of the membrane fusion machine
44. Antibody epitopes sensitive to the state of human immunodeficiency virus type 1 gp41 oligomerization map to a putative α-helical region
45. Human immunodeficiency virus type 1 envelope glycoprotein oligomerization requires the gp41 amphipathic α-helical/leucine zipper-like sequence
46. Complete nucleotide sequence of the AIDS virus, HTLV-III
47. Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides
48. Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion
49. Identification and mapping of functional domains on human T-cell lymphotropic virus type 1 envelope proteins by using synthetic peptides
50. Coiled coils in both intracellular vesicle and viral membrane fusion
51. Atomic structure of a thermostable subdomain of HIV-1 gp41
52. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
53. Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain
54. Structural basis for membrane fusion by enveloped viruses
55. Atomic structure of the ectodomain from HIV-1 gp41
56. Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection
57. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution
58. Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding
59. Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies
60. The crystal structure of the SIV gp41 ectodomain at 1:47 Å resolution
61. Structural characterization of the human respiratory syncytical virus fusion protein core