Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 23, 2003, Pages 4933-4940

  Isobe, Yoshiaki ^a   Tobe, Masanori ^a   Inoue, Yoshifumi ^a   Isobe, Masakazu ^a   Tsuchiya, Masami ^a   Hayashi, Hideya ^a,b  

^a JAPAN ENERGY CORPORATION   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINO 1 (2 BROMOPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (2 CHLOROPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (2 ETHOXYPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (2,3 DICHLOROPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (2,3 DIMETHOXYPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (3 BENZYLOXYPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDO) 3 METHYLURACIL; 6 AMINO 1 (3 BROMOPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (3 CHLOROPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (3 CYCLOPENTYLOXY 4 METHOXYPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 1 (3,4 DIMETHOXYPHENYL) 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYLURACIL; 6 AMINO 3 BUTYL 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 PHENYLURACIL; 6 AMINO 3 CYCLOHEXYL 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 PHENYLURACIL; 6 AMINO 3 ETHOXYCARBONYLMETHYL 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 PHENYLURACIL; 6 AMINO 3 ETHYL 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 PHENYLURACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 (2 METHOXYPHENYL) 3 METHYLURACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 (3 METHOXYPHENYL) 3 METHYLURACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 PHENYL 3 PROPYLURACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 1 PHENYLURACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYL 1 (2 METHYLTHIOPHENYL)URACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYL 1 (2 METHYPHENYL)URACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYL 1 (3 METHYLPHENYL)URACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 METHYL 1 (3 METHYLTHIOPHENYL)URACIL; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDE) 3 PENTYL 1 PHENYLURACIL; ANTIINFLAMMATORY AGENT; CX 659S; IMMUNOSUPPRESSIVE AGENT; PICRYL CHLORIDE; TACROLIMUS; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 0242329796     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.012     Document Type: Article

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