Suppressive effect of topically applied CX-659S, a novel diaminouracil derivative, on the contact hypersensitivity reaction in various animal models

International Archives of Allergy and Immunology

Volumn 123, Issue 4, 2000, Pages 341-348

  Goto, Yuso ^a   Inoue, Yoshifumi ^a   Tsuchiya, Masami ^a   Isobe, Masakazu ^a   Ueno, Takamasa ^a   Uchi, Hiroshi ^b   Furue, Masutaka ^b   Hayashi, Hideya ^a  

^a JAPAN ENERGY CORPORATION   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

2,4 Dinitrochlorobenzene; Contact hypersensitivity reaction; CX 659S; IL 1 ; Oxazolone; Picryl chloride; TNF ; Uracil derivatives

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 6 AMINO 5 (6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBOXAMIDO) 3 METHYL 1 PHENYL 2,4(1H,3H)PYRIMIDINEDIONE; ANTIINFLAMMATORY AGENT; CX 659S; CYTOKINE; HAPTEN; INTERLEUKIN 1BETA; OXAZOLONE; PICRYL CHLORIDE; PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CONTACT ALLERGY; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFICACY; EAR; EDEMA; ERYTHEMA; GENE EXPRESSION; GUINEA PIG; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADMINISTRATION, TOPICAL; ANIMALS; BASE SEQUENCE; DERMATITIS, CONTACT; DINITROCHLOROBENZENE; DISEASE MODELS, ANIMAL; DNA PRIMERS; GUINEA PIGS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; MALE; MICE; MICE, INBRED ICR; OXAZOLONE; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; URACIL;

EID: 0034512443     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053647     Document Type: Article

References (20)

1. Experiments on transfer of cutaneous sensitivity to simple chemical compounds
2. Mechanism in allergic contact dermatitis
3. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
4. Recent developments in the pathogenesis of allergic contact dermatitis
5. Epidermal cytokines in allergic contact dermatitis
6. An essential role for Langerhans cell-derived IL-1β in the initiation of primary immune responses in skin
7. Tumor necrosis factor is a critical mediator in hapten-induced irritant and contact hypersensitivity reactions
8. Role of T cells in atopic dermatitis: New aspects on the dynamics of cytokine production and the contribution of bacterial superantigens
9. Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction
10. Early molecular events in the induction phase of contact sensitivity
11. The mode of action of immunosuppressive agents; in Frontiers of Biology
12. Topical application of cyclosporine on guinea pig allergic contact dermatitis
13. Topical cyclosporine: Effects on allergic contact dermatitis in guinea pigs
14. Topical FK-506: Suppression of allergic and irritant contact dermatitis in the guinea pig
15. Substituted 9-benzyladenines: Inhibitors of inflammation associated with the delayed hypersensitivity skin reaction
16. Interleukin-1 receptor antagonist suppresses contact hypersensitivity
17. Immunosuppressive effects of transforming growth factor β: Inhibition of the induction of Ia antigen on Langerhans cells by cytokines and of the contact hypersensitivity response
18. Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide
19. Interleukin-1β induction of mitogen-activated protein kinases in human mesangial cells. Role of oxidation
20. Redox regulation of TNF signaling