Chemoreflex Drive and the Dynamics of Ventilation and Gas Exchange during Exercise at Hypoxia

American Journal of Respiratory and Critical Care Medicine

Volumn 168, Issue 9, 2003, Pages 1115-1122

  Fukuoka, Yoshiyuki ^a   Endo, Masako ^b   Oishi, Yasuharu ^b   Ikegami, Haruo ^b  

^a PREFECTURAL UNIVERSITY OF KUMAMOTO   (Japan)

^b NONE

Author keywords

Chemoreflex drive; Exercise; Hypercapnia; Hypoxia; Ventilatory dynamics

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ADULT; ARTICLE; BREATH ANALYSIS; CALCULATION; CAROTID BODY; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; CYCLING; DYNAMICS; EXERCISE TEST; GAS EXCHANGE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; HYPERPNEA; HYPOXIA; LUNG VENTILATION; MALE; OXYGEN BREATHING; OXYGEN SATURATION; PRIORITY JOURNAL;

ADULT; ANOXIA; BREATH TESTS; CAROTID BODY; CHEMORECEPTORS; EXERCISE; EXERCISE TEST; HUMANS; HYPERCAPNIA; MALE; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; REGRESSION ANALYSIS; RESPIRATORY MECHANICS;

EID: 0242301637     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.2202027     Document Type: Article

References (46)

1. Griffiths TL, Henson LC, Whipp BJ. Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man. J Physiol 1986;380:387-403.
2. Wasserman K, Whipp BJ, Koyal SN, Cleary MG. Effect of carotid body resection on ventilatory and acid-base control during exercise. J Appl Physiol 1975;39:354-358.
3. Sherrill DL, Swanson GD. Does the resting hypoxic drive predict the transient response to exercise? Concept and formalization in the control of breathing. In: Benchetrit G, Baconnier P, Demongeot J, editors. Manchester, UK: Manchester University Press; 1987. p. 133-142.
4. Weil JV, Byrne-Quinn E, Sodal IE, Kline JS, McCullough RE, Filley GF. Augmentation of chemosensitivity during mild exercise in normal man. J Appl Physiol 1972;33:813-819.
5. Grover RF, Cruz JC, Grover EB, Reeves JT. Exercise-dependent ventilatory sensitivity to hypoxia in Andean natives. Respir Physiol Neurobiol 2002;133:35-41.
6. Cummin AR, Alison J, Jacobi MS, Iyawe VI, Saunders KB. Ventilatory sensitivity to inhaled carbon dioxide around the control point during exercise. Clin Sci 1986;71:17-22.
7. Jacobi MS, Iyawe VI, Patil CP, Cummin AR, Saunders KB. Ventilatory responses to inhaled carbon dioxide at rest and during exercise in man. Clin Sci 1987;73:177-182.
8. Jacobi MS, Patil CP, Saunders KB. Transient, steady-state and rebreathing responses to carbon dioxide in man, at rest and during light exercise. J Physiol 1989;411:85-96.
9. 2 chemoreflex from rest to exercise. Eur J Appl Physiol 1995;70:360-366.
10. Clement ID, Pandit JJ, Bascom DA, Robbins PA. Ventilatory chemoreflexes at rest following a brief period of heavy exercise in man. J Physiol 1996;495:875-884.
11. Duffin J, Bechbache RR, Goode RC, Chung SA. The Ventilatory response to carbon dioxide in hyperoxic exercise. Respir Physiol 1980;40:93-105.
12. Kelley MA, Owens GR, Fishman AP. Hypercapnic ventilation during exercise: effects of exercise methods and inhalation techniques. Respir Physiol 1982;50:75-85.
13. McConnell AK, Semple ES. Ventilatory sensitivity to carbon dioxide: the influence of exercise and athleticism. Med Sci Sports Exerc 1996;28: 685-691.
14. Shea SA, Anders LP, Shannon DC, Banzett RB. Ventilatory responses to exercise in humans lacking Ventilatory chemosensitivity. J Physiol 1993;468:623-640.
15. Ward SA, Blesovsky L, Russak S, Ashjian A, Whipp BJ. Chemoreflex modulation of Ventilatory dynamics during exercise in humans. J Appl Physiol 1987;63:2001-2007.
16. Xing HC, Cochrane JE, Yamamoto Y, Hughson RL. Frequency domain analysis of ventilation and gas exchange kinetics in hypoxic exercise. J Appl Physiol 1991;71:2394-2401.
17. Gerbino A, Ward SA, Whipp BJ. Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans. J Appl Physiol 1996;80:99-107.
18. Linnarsson D. Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol Scand Suppl 1974; 415:1-68.
19. Murphy PC, Cuervo LA, Hughson RL. A study of cardiorespiratory dynamics with step and ramp exercise tests in normoxia and hypoxia. Cardiovasc Res 1989;23:825-832.
20. Davis JA, Vodak P, Wilmore JH, Vodak J, Kurtz P. Anaerobic threshold and maximal aerobic power for three modes of exercise. J Appl Physiol 1976;41:544-550.
21. Wasserman K, Whipp BJ, Koyl SN, Beaver WL. Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 1973;35:236-243.
22. O2 on-and off-kinetics in 50 year old subjects. Pflugers Arch 2002;443:690-697.
23. O2 responses to arm exercise in trained spinal cord-injured humans. Spinal Cord 2002;40:631-638.
24. Dejours P. Chemoreflex in breathing. Physiol Rev 1962;42:335-358.
25. Whipp BJ, Wasserman K. Carotid bodies and Ventilatory control dynamics in man. Fed Proc 1980;39:2668-2673.
26. Honda Y. Respiratory and circulatory activities in carotid body-resected humans. J Appl Physiol 1992;73:1-8.
27. Biscoe TJ, Purves MJ. Factors affecting the cat carotid chemoreceptor and cervical sympathetic activity with special reference to passive hind-limb movements. J Physiol 1967;190:425-441.
28. Heistad DD, Wheeler RC, Mark AL, Schmid PG, Abboud FM. Effects of adrenergic stimulation on ventilation in man. J Clin Invest 1972; 51:1469-1475.
29. Lugliani R, Whipp BJ, Seard C, Wasserman K. Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man. N Engl J Med 1971;285:1105-1111.
30. Hughson RL. Coupling of ventilation and gas exchange during transitions in work rate by humans. Respir Physiol 1995;101:87-98.
31. E kinetics during moderate-and heavy-intensity exercise after acetazolamide administration. J Appl Physiol 1999;86:1534-1543.
32. 2 stores on ventilatory dynamics during exercise. J Appl Physiol 1983;55: 742-749.
33. Brown HV, Wasserman K, Whipp BJ. Effect of beta-adrenergic blockade during exercise on ventilation and gas exchange. J Appl Physiol 1976; 41:886-892.
34. Wasserman K, Whipp BJ, Casaburi R, Beaver WL. Carbon dioxide flow and exercise hyperpnea: cause and effect. Am Rev Respir Dis 1977;115: 225-237.
35. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, Mitchell JH. Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J Appl Physiol 1983;55:105-112.
36. Kaufman MP. Discharge properties of group III and IV muscle afferents. In: Speck DF, Dekin MS, Revellete WR, Frazier DT, editors. Central and peripheral mechanisms in the control of breathing. Lexington, KY: University Press of Kentucky; 1993. p. 120-124.
37. Fregosi RF, Seals DR. Hypoxic potentiation of the ventilatory response to dynamic forearm exercise. J Appl Physiol 1993;74:2365-2372.
38. Masson RG, Lahiri S. Chemical control of ventilation during hypoxic exercise. Respir Physiol 1974;22:241-262.
39. Eldridge FL. Central integration of mechanisms in exercise hyperpnea. Med Sci Sports Exerc 1994;26:319-327.
40. Oren A, Whipp BJ, Wasserman K. Effect of acid-base status on the kinetics of the ventilatory response to moderate exercise. J Appl Physiol 1982;52:1013-1017.
41. Oren A, Whipp BJ, Wasserman K. Effects of chronic acid-base changes on the rebreathing hypercapnic ventilatory response in man. Respiration (Herrlisheim) 1991;58:181-185.
42. Pianosi P, Marchione T. Hypoxic response is inversely related to degree of exercise hyperventilation. Respir Physiol 1995;101:71-78.
43. Martin BJ, Weil JV, Sparks KE, McCullough RE, Grover RF. Exercise ventilation correlates positively with ventilatory chemoresponsiveness. J Appl Physiol 1978;45:557-564.
44. Takano N, Inaishi S, Zhang Y. Individual differences in breathlessness during exercise, as related to ventilatory chemosensitivities in humans. J Physiol 1997;499:843-848.
45. Springer C, Barstow TJ, Wasserman K, Cooper DM. Oxygen uptake and heart rate responses during hypoxic exercise in children and adults. Med Sci Sports Exerc 1991;23:71-79.
46. 2 uptake and heart rate kinetics during heavy exercise. J Appl Physiol 1996;81:2500-2508.