Antinociceptive Activity of Sempervivum tectorum L. Extract in Rats

Phytotherapy Research

Volumn 17, Issue 9, 2003, Pages 1032-1036

  Kekesi, Gabriella ^a   Dobos, Ildiko ^a   Benedek, György ^a   Horvath, Gyöngyi ^a,b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Antinociception; Intraperitoneal; Intrathecal; Plant extract; Rats; Sempervivum tectorum

Indexed keywords

CARRAGEENAN; PLANT EXTRACT; SEMPERVIVUM TECTORUM L EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CRASSULACEAE; EXPERIMENTAL TEST; HEAT; HYPERALGESIA; INFLAMMATION; MALE; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; PAW WITHDRAWAL TEST; RAT; SEMPERVIVUM TECTORUM L; SPINAL CORD; STATISTICAL SIGNIFICANCE; TAIL FLICK TEST; THERMAL STIMULATION; WAKEFULNESS;

ANALGESICS; ANIMALS; CRASSULACEAE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SPINAL; MALE; PAIN; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR;

CRASSULACEAE; SEMPERVIVUM; SEMPERVIVUM TECTORUM;

EID: 0242300105     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1288     Document Type: Article

References (25)

1. Abram V, Donko M. 1999. Tentative identification of polyphenols in Sempervivum tectorum and assessment of the antimicrobial activity of Sempervivum L. J Agric Food Chem 47: 485-489.
2. Blazso G, Gabor M. 1994. Influence of O-(beta-hydroxyethyl)rutin on the oedema-inhibiting effect of indomethacin. Acta Pharm Hung 64: 123-124.
3. Blazso G, Gabor M, Rohdewald P. 1997. Antiinflammatory activities of procyanidin-containing extract from Pinus pinaster Ait. after oral and cutaneous application. Pharmazie 52: 380-382.
4. Blázovics A, Fehér J, Fehér E, Kéry A, Petri G. 1993a. Liver protecting and lipid lowering effects of Sempervivum tectorum extract in the rat. Phytother Res 7: 98-100.
5. Blázovics A, González-Cabello R, Barta I, et al. 1994. Effect of liver-protecting Sempervivum tectorum extract on the immune reactivity of spleen cells in hyperlipidaemic rats. Phythother Res 8: 33-37.
6. Blázovics A, Horváth EM, Barta I, et al. 1993b. Sempervivum tectorum and liver regeneration. In Oxygen Free Radicals and Scavengers in the Natural Sciences, Mózsik G, Emerit I, Fehér J, Matkovics B, Vincze A (eds). Akadémiai Kiadó: Budapest; 293-300.
7. Blázovics A, Lugasi A, Kemény T, Hagymási K, Kéry A. 2000. Membrane stabilising effects of natural polyphenols and flavonoids from Sempervivum tectorum on hepatic microsomal mixed-function oxidase system in hyperlipidemic rats. J Ethnopharmacol 73: 479-485.
8. Calixto JB, Beirith A, Ferreira J, Santos ARS, Filho VC, Yunes RA. 2000. Naturally occurring antinociceptive substances from plants. Phythother Res 14: 401-418.
9. Gabor M. 1981. The effect of O-(beta-hydroxyethyl)-rutosides (HR) on the skin capillary resistance of rats. Arzneimittelforschung 31: 442-445.
10. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. 1988. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88.
11. Kéry A, Blázovics A, Rozlosnik N, Fehér J, Petri G. 1992. Antioxidative properties of extracts from Sempervivum tectorum. Planta Med 58: A661-A662.
12. Kéry A, Petri G, Blázovics A, Prónai L, Fehér J. 1993. A natural antioxidant extract form Sempervivum tectorum. Phythother Res 7: 95-97.
13. Kéry A, Blázovics A, Fejes S, Prónai L, Bálványos I, Petri G. 1995. Antioxidant activity of medicinal plants with phytotherapeutical significance. Society for Free Radical Research, Summer Meeting, Budapest July 27-29: 100.
14. Kéry A, Blázovics A, Fejes S, Lugasi A. 1997. Antioxidant activity of some medicinal plants used in gastrointestinal disorders. Second Intestinal Symposium on Natural Drugs, Dijon, France: 143.
15. Martineuz-Vazquez M, Ramirez Apan TO, Hidemi Agilar M, Bye R. 1996. Analgesic and antipyretic activities of an aqueous extract and of the flavone linarin of Buddleia cordata. Planta Med 62: 137-140.
16. Martineuz-Vazquez M, Ramirez Apan TO, Lastra AL, Bye R. 1998. A comparative study of the analgesic and antiinflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata. Planta Med 64: 134-137.
17. Medina JH, Paladini AC, Wolfman C, et al. 1990. Chrysin (5,7-di-OH-flavone), a naturally-occuring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol 40: 2227-2231.
18. Penso G. 1982. Index Plantarum Medicinalium. OEMF: Milano.
19. Picq M, Cheav SL, Prigent AF. 1991. Effect of two flavonoid compounds on central nervous system. Analgesic activity. Life Sci 49: 1979-1988.
20. Ramaswamy S, Pillai NP, Gopalakrishnan V, Parmar NS. 1980. Analgesic activity of a bioflavonoid in mice. Indian J Pharmacol 12: 33.
21. Sátory E, Petri G, Kéry A, Blazics G. 1988. The measurement of the effect of an antiphlogistic agent against otitis. Pharmacy (Hung) 32: 486.
22. Szentmihályi K, Blázovics A, Kocsis I, Kéry A, Vinckler P, Fehér E. 1999. Effect of Sempervivum tectorum extract on ion concentration in bile fluid in rats. Z Gastroenterol 37: 448.
23. Thirugnanasambantham P, Viswanathan S, Kannappa R, Ramachandra S. 1985. Analgesic activity of certain bioflavonoids. Indian J Pharm Sci 47: 230.
24. Thirugnanasambantham P, Viswanathan S, Ramaswamy S, et al. 1988. Involvement of calcium in flavonoid analgesia. Eur J Pharmacol 152: 367-369.
25. Viswanathan S, Thirugnanasambantham P, Kannappa R, Kameswaran L. 1984. Gossypin-induced analgesia in mice. Eur J Pharmacol 98: 289-291.