Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 23, 2003, Pages 5117-5133

  Kubo, Kazuo ^a   Ohyama, Shin Ichi ^a   Shimizu, Toshiyuki ^a   Takami, Atsuya ^a   Murooka, Hideko ^a   Nishitoba, Tsuyoshi ^a   Kato, Shinichiro ^a   Yagi, Mikio ^a   Kobayashi, Yoshiko ^a   Iinuma, Noriko ^a   Isoe, Toshiyuki ^a   Nakamura, Kazuhide ^a   Iijima, Hiroshi ^a   Osawa, Tatsushi ^a   Izawa, Toshio ^a  

^a KIRIN BREWERY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

(4 TERT BUTYLPHENYL)[4 [(6,7 DIMETHOXY 4 QUINOLYL)OXY]PHENYL]METHANONE; 4 PHENOXYQUINOLINE DERIVATIVE; 6,7 DIMETHOXY 4 (2 METHOXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (2,3 DIMETHOXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (2,6 DIMETHOXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3 ACETYLPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3 BROMOPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3 FLUOROPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3 HYDROXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3 METHOXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3 METHYLPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3,4 DIMETHOXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (3,5 DIMETHOXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (4 ACETYLPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (4 BROMOPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (4 HYDROXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 (4 METHOXYPHENOXY)QUINOLINE; 6,7 DIMETHOXY 4 PHENOXYQUINOLINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; KI 6783; KI 6896; KI 6945; METHYL 3 [(6,7 DIMETHOXY 4 QUINOLYL)OXY]BENZOATE; N [4 METHYL 3 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINO]PHENYL]BENZAMIDE; N [4 [(6,7 DIMETHOXY 4 QUINOLYL)OXY]PHENYL](4 TERT BUTYLPHENYL)CARBOXAMIDE; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [2 [(6,7 DIMETHOXY 4 QUINOLYL)OXY]PHENYL]PHENYLMETHANONE; [3 [(6,7 DIMETHOXY 4 QUINOLYL)OXY]PHENYL]PHENYL]METHANONE; [4 [(6,7 DIMETHOXY 4 QUINOLYL)OXY]PHENYL]PHENYL]METHANONE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0242298231     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.08.020     Document Type: Article

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