Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loading

Physiological Genomics

Volumn 14, Issue , 2003, Pages 209-216

  Mehr, Ali Poyan ^a   Siegel, Anja Kristin ^a   Kossmehl, Peter ^a   Schulz, Angela ^a   Plehm, Ralph ^b   De Bruijn, Jan A ^c   De Heer, Emile ^a   Kreutz, Reinhold ^a,d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Genetics; Linkage; Quantitative trait loci

Indexed keywords

ALBUMIN; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CHROMOSOME; CHROMOSOME MAP; CHROMOSOME MARKER; CHROMOSOME RNO; CHROMOSOME RNO10; CHROMOSOME RNO11; CHROMOSOME RNO19; CHROMOSOME RNO2; CHROMOSOME RNO6; CHROMOSOME RNO8; CHROMOSOME RNO9; CONTROLLED STUDY; GENETIC TRAIT; GENOME WIDE LINKAGE; GLOMERULUS; LINKAGE ANALYSIS; MALE; MULTIFACTORIAL INHERITANCE; NONHUMAN; PHENOTYPE; POLYGENETIC TRAIT; PRIORITY JOURNAL; PROTEINURIA; QUANTITATIVE TRAIT LOCUS; RAT; RAT STRAIN; SALT LOADING; SODIUM RESTRICTION; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; TELEMETRY; URINARY ALBUMIN EXCRETION; URINARY EXCRETION; ALBUMINURIA; ANIMAL; BLOOD PRESSURE; COMPARATIVE STUDY; CROSS BREEDING; DAHL SALT SENSITIVE RAT; FEMALE; GENETIC LINKAGE; GENETICS; GENOME; GENOTYPE; PATHOPHYSIOLOGY; QUANTITATIVE TRAIT; SALT INTAKE;

ANIMALIA; GLOMERULUS;

ALBUMINURIA; ANIMALS; BLOOD PRESSURE; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; GENOME; GENOTYPE; LINKAGE (GENETICS); MALE; MULTIFACTORIAL INHERITANCE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; RATS; RATS, INBRED DAHL; RATS, INBRED SHR; SODIUM CHLORIDE, DIETARY;

EID: 0242292135     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00053.2003     Document Type: Article

References (30)

1. Branten AJ, Van Den BJ, Jansen JL, Assmann KJ, and Wetzels JF. Familial nephropathy differing from minimal change nephropathy and focal glomerulosclerosis. Kidney Int 59: 693-701, 2001.
2. Fogarty DG, Hanna LS, Wantman M, Warram JH, Krolewski AS, and Rich SS. Segregation analysis of urinary albumin excretion in families with type 2 diabetes. Diabetes 49: 1057-1063, 2000.
3. Fogarty DG, Rich SS, Hanna L, Warram JH, and Krolewski AS. Urinary albumin excretion in families with type 2 diabetes is heritable and genetically correlated to blood pressure. Kidney Int 57: 250-257, 2000.
4. Garrett MR, Dene H, and Rapp JP. Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. J Am Soc Nephrol 14: 1175-1187, 2003.
5. Garrett MR, Joe B, Dene H, and Rapp JP. Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains. J Hypertens 20: 2399-2406, 2002.
6. Garrett MR, Saad Y, Dene H, and Rapp JP. Blood pressure QTL that differentiate Dahl salt-sensitive and spontaneously hypertensive rats. Physiol Genomics 3: 33-38, 2000.
7. Hilbert P, Lindpaintner K, Beckmann JS, Serikawa T, Soubrier F, Dubay C, Cartwright P, de Gouyon B, Julier C, Takahasi S, Vincent M, Ganten D, Georges M, and Lathrop GM. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353: 521-529, 1991.
8. Iordache BE, Imberti O, Foglieni C, Remuzzi G, Bertani T, and Remuzzi A. Effects of angiotensin-converting enzyme inhibition on glomerular capillary wall ultrastructure in MWF/Ztm rats. J Am Soc Nephrol 5: 1378-1384, 1994.
9. Ketteler M, Westenfeld R, Gawlik A, Bachmann S, Frey A, Schonfelder G, Paul M, Distler A, and de Heer E. Nitric oxide synthase isoform expression in acute versus chronic anti-Thy 1 nephritis. Kidney Int 61: 826-833, 2002.
10. Kootstra CJ, Bergijk EC, Veninga A, Prins FA, de Heer E, Abrahamson DR, and Bruijn JA. Qualitative alterations in laminin expression in experimental lupus nephritis. Am J Pathol 147: 476-488, 1995.
11. Kreutz R, Hübner N, James MR, Bihoreau MT, Gaugier D, Lathrop GM, Ganten D, and Lindpaintner K. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc Natl Acad Sci USA 92: 8778-8782, 1995.
12. Kreutz R, Kovacevic L, Schulz A, Rothermund L, Ketteler M, and Paul M. Effect of high NaCl diet on spontaneous hypertension in a genetic rat model with reduced nephron number. J Hypertens 18: 777-782, 2000.
13. Kurtz TW and Morris RCJ. Hypertension in the recently weaned Dahl salt-sensitive rat despite a diet deficient in sodium chloride. Science 230: 808-810, 1985.
14. Lander E and Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11: 241-247, 1995.
15. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, and Newburg L. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174-181, 1987.
16. Lenz O, Zheng F, Vilar J, Doublier S, Lupia E, Schwedler S, Striker LJ, and Striker GE. The inheritance of glomerulosclerosis in mice is controlled by multiple quantitative trait loci. Nephrol Dial Transplant 13: 3074-3078, 1998.
17. Macconi D, Ghilardi M, Bonassi ME, Mohamed EI, Abbate M, Colombi F, Remuzzi G, and Remuzzi A. Effect of angiotensin-converting enzyme inhibition on glomerular basement membrane permeability and distribution of zonula occludens-1 in MWF rats. J Am Soc Nephrol 11: 477-489, 2000.
18. Mann JF, Gerstein HC, Pogue J, Bosch J, and Yusuf S. Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial. Ann Intern Med 134: 629-636, 2001.
19. Murayama S, Yagyu S, Higo K, Ye C, Mizuno T, Oyabu A, Ito M, Morita H, Maeda K, Serikawa T, and Matsuyama M. A genetic locus susceptible to the overt proteinuria in BUF/Mna rat. Mamm Genome 9: 886-888, 1998.
20. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev 80: 135-172, 2000.
21. Rothermund L, Luckert S, Kossmehl P, Paul M, and Kreutz R. Renal endothelin ET(A)/ET(B) receptor imbalance differentiates salt-sensitive from salt-resistant spontaneous hypertension. Hypertension 37: 275-280, 2001.
22. Ruilope LM, Salvetti A, Jamerson K, Hansson L, Warnold I, Wedel H, and Zanchetti A. Renal function and intensive lowering of blood pressure in hypertensive participants of the hypertension optimal treatment (HOT) study. J Am Soc Nephrol 12: 218-225, 2001.
23. Schulz A, Litfin A, Kossmehl P, and Kreutz R. Genetic dissection of increased urinary albumin excretion in the Munich Wistar Fromter rat. J Am Soc Nephrol 13: 2706-2714, 2002.
24. Shibutani M and Uneyama C. Methacarn: a fixation tool for multipurpose genetic analysis from paraffin-embedded tissues. Methods Enzymol 356: 114-125, 2002.
25. Shiozawa M, Provoost AP, van Dokkum RP, Majewski RR, and Jacob HJ. Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. J Am Soc Nephrol 11: 2068-2078, 2000.
26. Stella P, Cusi D, Duzzi L, and Bianchi G. Relations between hypertension and glomerulosclerosis in first-generation hybrid rats of the Milan strains. Child Nephrol Urol 11: 6-9, 1991.
27. Sterzel RB, Luft FC, Gao Y, Schnermann J, Briggs JP, Ganten D, Waldherr R, Schnabel E, and Kriz W. Renal disease and the development of hypertension in salt-sensitive Dahl rats. Kidney Int 33: 1119-1129, 1988.
28. Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, and Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res 10: 473-482, 2000.
29. Topham PS, Kawachi H, Haydar SA, Chugh S, Addona TA, Charron KB, Holzman LB, Shia M, Shimizu F, and Salant DJ. Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin. J Clin Invest 104: 1559-1566, 1999.
30. Van Dixhoorn MG, Salazar-Exaire D, Sato T, Daha MR, Quigg RJ, Bruijn JA, Couser WG, and de Heer E. Antivitronectin antibodies enhance anti-Thy-1-induced proteinuria in PVG/c, but not in Wistar rats. J Am Soc Nephrol 9: 994-1007, 1998.