New Rat Model of Pneumocystis Pneumonia Induced by Anti-CD4+ T-Lymphocyte Antibodies

Infection and Immunity

Volumn 71, Issue 11, 2003, Pages 6292-6297

  Thullen, Timothy D ^a,b,c   Ashbaugh, Alan D ^b   Daly, Kieran R ^b   Linke, Michael J ^a,b   Steele, Paul E ^c,d   Walzer, Peter D ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Division of Infectious Disease   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CORTICOSTEROID; EPITOPE; MONOCLONAL ANTIBODY; OX38 ANTIBODY; T LYMPHOCYTE ANTIBODY; UNCLASSIFIED DRUG; W3 25 ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE MODEL; DISEASE SEVERITY; DRUG EFFECT; HOST RESISTANCE; INFECTION RESISTANCE; LYMPHOCYTE DEPLETION; MALE; NONHUMAN; OPPORTUNISTIC INFECTION; PNEUMOCYSTIS; PNEUMONIA; PRIORITY JOURNAL; RAT; RAT STRAIN; T LYMPHOCYTE;

ADRENAL CORTEX HORMONES; ANIMALS; ANTIBODIES, MONOCLONAL; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; MALE; PNEUMONIA, PNEUMOCYSTIS; RATS; RATS, INBRED LEW;

EID: 0242286558     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.11.6292-6297.2003     Document Type: Article

References (43)

1. Aliouat, E. M., A. Martinez, E. Jimenez, E. Dei-Cas, C. Mullet, P. Delcourt, and D. Gargallo-Viola. 1997. Development of pneumocystosis animal models: corticosteroid-treated Wistar rat, SCID mouse and nude rat. J. Eukaryot. Microbiol. 44:41S-42S.
2. Arima, T., M. Lehmann, and M. W. Flye. 1997. Induction of donor specific transplantation tolerance to cardiac allografts following treatment with non-depleting (RIB 5/2) or depleting (OX-38) anti-CD4 mAb plus intrathymic or intravenous donor alloantigen. Transplantation 63:284-292.
3. Armstrong, M. Y. and M. T. Cushion. 1994. Animal models, p. 181-222. In P. D. Walzer (ed.), Pneumocystis carinii pneumonia, 2nd ed. Marcel Dekker, Inc., New York, N.Y.
4. + lymphocytes in host defense against Pneumocystis carinii in mice. J. Lab. Clin. Med. 128:477-487.
5. Billingham, M. E., C. Hicks, and S. Carney. 1990. Monoclonal antibodies and arthritis. Agents Actions 29:77-87.
6. Cushion, M. T. 1998. Taxonomy, genetic organization, and life cycle of Pneumocystis carinii. Semin. Respir. Infect. 13:304-312.
7. Dei-Cas, E., M. Brun-Pascaud, V. Bille-Hansen, A. Allaert, and E. M. Aliouat. 1998. Animal models of pneumocystosis. FEMS Immunol. Med. Microbiol. 22:163-168.
8. Flavin, T., J. Shizuru, K. Seydel, A. Wu, N. Fujimoto, E. G. Hoyt, K. Ivens, M. Billingham, C. G. Fathman, and V. A. Starnes. 1990. Selective T-cell depletion with Ox-38 anti-CD4 monoclonal antibody prevents cardiac allograft rejection in rats. J. Heart Transplant. 9:482-488.
9. Frenkel, J. K., J. T. Good, and J. A. Shultz. 1966. Latent pneumocystis infection of rats, relapse and chemotherapy. Lab. Investig. 15:1559-1577.
10. Furuta, T., M. Fujita, K. Machii, K. Kobayashi, S. Kojima, and K. Ueda. 1993. Fatal spontaneous pneumocystosis in nude rats. Lab. Anim. Sci. 43:551-556.
11. Furuta, T., K. Ueda, S. Kyuwa, and K. Fujiwara. 1984. Effect of T-cell transfer on Pneumocystis carinii infection in nude mice. Jpn. J. Exp Med. 54:57-64.
12. Gigliotti, F., C. G. Haidaris, T. W. Wright, and A. G. Harmsen. 2002. Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia. Infect. Immun. 70:1069-1074.
13. Hanano, R., K. Reifenberg, and S. H. E. Kaufmann. 1996. Naturally acquired Pneumocystis carinii pneumonia in gene disruption mutant mice: roles of distinct T-cell populations in infection. Infect. Immun. 64:3201-3209.
14. + cells in resistance to Pneumocystis carinii pneumonia in mice. J. Exp. Med. 172:937-945.
15. Jefferies, W. A., J. R. Green, and A. F. Williams. 1985. Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages. J. Exp. Med. 162:117-127.
16. Kim, C. K., J. M. Foy, M. T. Cushion, D. Stanforth, M. J. Linke, H. L. Hendrix, and P. D. Walzer. 1987. Comparison of histologic and quantitative techniques in evaluation of therapy for experimental Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 31:197-201.
17. Lehmann, M., E. Graser, K. Risch, W. W. Hancock, A. Muller, B. Kuttler, H. J. Hahn, J. W. Kupiec-Weglinski, J. Brock, and H. D. Volk. 1997. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells. Transplantation 64:1181-1187.
18. Linke, M. J., C. E. Harris, T. R. Korfhagen, F. X. McCormac, A. D. Ashbaugh, P. Seele, J. A. Whitsett, and P. D. Walzer. 2001. Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection. J. Infect. Dis. 183:943-952.
19. Marcotte, H., D. Levesque, K. Delanay, A. Bourgeault, R. de la Durantaye, S. Brochu, and M. C. Lavoie. 1996. Pneumocystis carinii infection in transgenic B cell-deficient mice. J. Infect. Dis. 173:1034-1037.
20. Martin, W. J., and R. Pasula. 2000. Role of alveolar macrophages in host defense against Pneumocystis carinii. Am. J. Respir. Cell Mol. Biol. 23:434-435.
21. Morrison, W. J., N. J. Kennedy, H. Offner, and A. A. Vandenbark. 1995. Effects of anti-CD4 antibody: enhancement of lymph node PPD-memory T cell response. Cell. Immunol. 163:106-112.
22. Oz, H. S., W. T. Hughes, J. E. Rehg, and E. K. Thomas. 2000. Effect of CD40 ligand and other immunomodulators on Pneumocystis carinii infection in rat model. Microb. Pathog. 29:187-190.
23. Pelegri, C., M. Castell, M. Serra, M. Rabanal, M. Rodriguez-Palmero, C. Castellote, and A. Franch. 2001. Prevention of adjuvant arthritis by the W3/25 anti-CD4 monoclonal antibody is associated with a decrease of blood CD4(+)CD45RC(high) T cells. Clin. Exp. Immunol. 125:470-477.
24. Perenboom, R. M., P. Beckers, J. W. van der Meer, A. C. van Schijndel, W. J. Oyen, F. H. Corstens, and R. W. Sauerwein. 1996. Pro-inflammatory cytokines in lung and blood during steroid-induced Pneumocystis carinii pneumonia in rats. J. Leukoc. Biol. 60:710-715.
25. Phair, J., A. Munoz, R. Detels, R. Kaslow, C. Rinaldo, A. Saah, et al. 1990. The risk of Pneumocystis carinii pneumonia among men infected with human immunodeficiency virus type 1. N. Engl. J. Med. 322:161-165.
26. Pleyer, U., J. K. Milani, A. Dukes, J. Chou, S. Lutz, D. Ruckert, H. J. Thiel, and B. J. Mondino. 1995. Effect of topically applied anti-CD4 monoclonal antibodies on orthotopic corneal allografts in a rat model. Investig. Ophthalmol. Vis. Sci. 36:52-61.
27. Pohlmeyer, G., and F. Deerberg. 1993. Nude rats as a model of natural Pneumocystis carinii pneumonia: sequential morphological study of lung lesions. J. Comp. Pathol. 109:217-230.
28. Reynolds, J., and C. D. Pusey. 1994. In vivo treatment with a monoclonal antibody to T helper cells in experimental autoimmune glomerulonephritis in the BN rat. Clin. Exp. Immunol. 95:122-127.
29. Roths, J. B., and C. L. Sidman. 1993. Single and combined humoral and cell-mediated immunotherapy of Pneumocystis carinii pneumonia in immunodeficient scid mice. Infect. Immun. 61:1641-1649.
30. Schmatz, D. M., M. A. Romancheck, L. A. Pittarelli, R. E. Schwartz, R. A. Fromtling, K. H. Nollstadt, F. L. Vanmiddlesworth, K. E. Wilson, and M. J. Turner. 1990. Treatment of Pneumocystis carinii pneumonia with 1, 3-β-glucan synthesis. Proc. Natl. Acad. Sci. USA 87:5950-5954.
31. Shellito, J., V. V. Suzara, W. Blumenfeld, J. M. Beck, H. J. Steger, and T. H. Ermak. 1990. A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes. J. Clin. Investig. 85:1686-1693.
32. Shultz, L. D., P. A. Schweitzer, E. J. Hall, J. P. Sundberg, S. Taylor, and P. D. Walzer. 1989. Pneumocystis carinii pneumonia in scid/scid mice. Curr. Top. Microbiol. Immunol. 152:243-249.
33. Stringer, J. R., and P. D. Walzer. 1996. Molecular biology and epidemiology of Pneumocystis carinii infection in AIDS. AIDS 10:561-571.
34. + T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J. Exp. Med. 182:5-13.
35. Theus, S. A., R. P. Andrews, P. Steele, and P. D. Walzer. 1995. Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat. J. Clin. Investig. 95:2587-2593.
36. Theus, S. A., A. G. Smulian, P. Steele, M. J. Linke, and P. D. Walzer. 1998. Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response. Vaccine 16:1149-1157.
37. Theus, S. A., and P. D. Walzer. 1997. Adoptive transfer of specific lymphocyte populations sensitized to the major surface glycoprotein of Pneumocystis carinii decreases organism burden while increasing survival rate in the rat. J. Eukaryot. Microbiol. 44:23S-24S.
38. Walzer, P. D., M. LaBine, T. J. Redington, and M. T. Cushion. 1984. Lymphocyte changes during chronic administration of and withdrawal from corticosteroids: relation to Pneumocystis carinii pneumonia. J. Immunol. 133:2502-2508.
39. Webb, M., D. W. Mason, and A. F. Williams. 1979. Inhibition of mixed lymphocyte response by monoclonal antibody specific for a rat T lymphocyte subset. Nature 282:841-843.
40. Wiley, J. A., and A. G. Harmsen. 1995. CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice. J. Immunol. 155:3525-3529.
41. Wright, T. W., F. Gigliotti, J. N. Finkelstein, J. T. McBride, C. L. An, and A. G. Harmsen. 1999. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J. Clin. Investig. 104:1307-1317.
42. Wright, T. W., C. J. Johnston, A. G. Harmsen, and J. N. Finkelstein. 1997. Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice. Am. J. Respir. Cell Mol. Biol. 17:491-500.
43. Wright, T. W., C. J. Johnston, A. G. Harmsen, and J. N. Finkelstein. 1999. Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation. Infect. Immun. 67:3452-3460.