Counterregulatory Hormone and Symptom Responses to Insulin-Induced Hypoglycemia in the Postprandial State in Humans

Diabetes

Volumn 52, Issue 11, 2003, Pages 2774-2783

  Porcellati, Francesca ^b   Pampanelli, Simone ^b   Rossetti, Paolo ^b   Cordoni, Cristina ^b   Marzotti, Stefania ^b   Scionti, Luciano ^b   Bolli, Geremia B ^b   Fanelli, Carmine G ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; GLUCAGON; INSULIN; NORADRENALIN; PANCREAS POLYPEPTIDE;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GLUCAGON BLOOD LEVEL; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NORADRENALIN BLOOD LEVEL; POSTPRANDIAL STATE; PRIORITY JOURNAL; SYMPTOMATOLOGY;

ADULT; AREA UNDER CURVE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 1; EPINEPHRINE; GLUCAGON; GLUCOSE; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; HYPOGLYCEMIA; INFUSIONS, INTRAVENOUS; INSULIN; KINETICS; NOREPINEPHRINE; PANCREATIC POLYPEPTIDE; POSTPRANDIAL PERIOD; POSTURE; REFERENCE VALUES;

EID: 0242268900     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.11.2774     Document Type: Article

References (38)

1. Cryer PE: Glucose counterregulation: the prevention and correction of hypoglycemia in humans. Am J Physiol 264:E144-E155, 1993
2. Bolli GB, Fanelli CG: Physiology of glucose counterregulation to hypoglycemia. Endocrinol Metab Clin North Am 28:467-493, 1999
3. Donovan CM, Hamilton-Wessler M, Halter JB, Bergman RN: Primacy of liver glucosensors in the sympathetic response to progressive hypoglycaemia. Proc Natl Acad Sci U S A 91:2863-2867, 1994
4. Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH: Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 182:171-173, 1973
5. Burge MR, Castillo KR, Schade DS: Meal composition is a determinant of lispro-induced hypoglycemia in IDDM. Diabetes Care 20:152-155, 1997
6. Bolli GB, Di Marchi RD, Park GD, Pramming S, Koivisto VA: Insulin analogues and their potential in the management of diabetes mellitus. Diabetologia 42:1151-1167, 1999
7. Ewing DJ, Clarke BF: Autonomic neuropathy: its diagnosis and prognosis. Clin Endocrinol Metab 15:855-888, 1986
8. Fanelli CG, Epifano L, Rambotti AM, Pampanelli S, Di Vincenzo A, Modarelli F, Lepore M, Annibale B, Ciofetta M, Bottini P, Porcellati F, Scionti L, Santeusanio F, Brunetti P, Bolli GB: Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes 42:1683-1689, 1993
9. McGuire E, Helderman J, Tobin J, Andres R, Berman M: Effects of arterial venous sampling on analysis of glucose kinetics in man. J Appl Physiol 41:565-573, 1976
10. De Feo P, Perriello G, Ventura MM, Calcinaro F, Basta G, Lolli C, Cruciani C, Dell'Olio A, Santeusanio F, Brunetti P, Bolli GB: Studies on overnight insulin requirements and metabolic clearance rate of insulin in normal and diabetic man: relevance to the pathogenesis of the dawn phenomenon. Diabetologia 29:475-480, 1986
11. Fanelli CG, De Feo P, Porcellati F, Perriello G, Torlone E, Santeusanio F, Brunetti P, Bolli GB: Adrenergic mechanisms contribute to the late phase of hypoglycemic glucose counterregulation in humans by stimulating lipolysis. J Clin Invest 89:2005-2013, 1992
12. Kohn A, Annibale B, Suriano G, Severi C, Spinella S, Delle Fave G: Gastric acid and pancreatic polypeptide responses to modified sham feeding: indication of an increased basal vagal tone in a subgroup of duodenal ulcer patients. Gut 26:776-782, 1985
13. Kuzuya H, Blix PN, Horowitz DL, Steiner DF, Rubenstein AH: Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes 26:22-29, 1977
14. Buzzigoli G, Lanzone L, Ciociaro D, Frascerra S, Cerri M, Scandroglio A, Coldani R, Ferrannini E: Characterization of a reversed-phase high-performanceliquid chromatographic system for the determination of blood aminoacids. J Chromatography 507:85-93, 1990
15. Winer BJ, Brown DR, Michels KM: Statistical Principles in Experimental Design. 3rd ed. New York, McGraw Hill, 1991, p. 497-580
16. Hintze J: NCSS and PASS (2001). Number Cruncher Stastistical Systems. Kaysville, Utah. Available from http://www.ncss.com. Accessed 2 December 2002.
17. Katsuura G, Asakawa A, Inui A: Roles of pancreatic polypeptide in regulation of food intake. Peptides 23:323-329, 2002
18. Taborsky GJ Jr., Ahren B, Havel PJ: Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired α-cell responses in type 1 diabetes. Diabetes 47:995-1005, 1998
19. Frier BM, Corrall RJ, Ashby JP, Baird JD: Attenuation of the pancreatic beta cell response to a meal following hypoglycaemia in man. Diabetologia 18:297-300, 1980
20. Oskarsson PR, Lins PE, Ahre B, Adamson UC: Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes. Eur J Endocrinol 142:30-34, 2000
21. Schmid R, Schusdziarra V, Schulte-Frohlinde E, Maier V, Classen M: Role of amino acids in stimulation of postprandial insulin, glucagon, and pancreatic polypeptide in humans. Pancreas 4:305-315, 1989
22. Nair KS, Welle SL, Tito J: Effect of plasma amino acid replacement on glucagon and substrate responses to insulin-induced hypoglycemia in humans. Diabetes 39:376-382, 1990
23. Wiethop BV, Cryer PE: Glycemic actions of alanine and terbutaline in IDDM. Diabetes Care 16:1124-1130, 1993
24. Heptulla RA, Tamborlane WV, Ma T Y-Z, Rife F, Sherwin RS: Oral glucose augments the counterregulatory hormone response during insulin-induced hypoglycemia in humans. J Clin Endocrinol Metab 86:645-648, 2001
25. Tse TF, Clutter WE, Shah SD, Miller JP, Cryer PE: Neuroendocrine responses to glucose ingestion in man: specificity, temporal relationships, and quantitative aspects. J Clin Invest 72:270-277, 1983
26. Capaldo B, Gastaldelli A, Antoniello S, Auletta M, Pardo F, Ciociaro D, Guida R, Ferrannini E, Sacca L: Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans. Diabetes 48:958-966, 1999
27. Bolli G, De Feo P, Compagnucci P, Cartechini MG, Angeletti G, Santeusanio F, Brunetti P, Gerich JE: Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32:134-141, 1983
28. Caprio S, Tamborlane WV, Zych K, Gerow K, Sherwin RS: Loss of potentiating effect of hypoglycemia on the glucagon response to hyperaminoacidemia in IDDM. Diabetes 42:550-555, 1993
29. Wiethop BV, Cryer PE: Alanine and terbutaline in treatment of hypoglycemia in IDDM. Diabetes Care 6:1131-1136, 1993
30. Ahren B, Holst JJ: The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 50:1030-1038, 2001
31. Taylor IL: Pancreatic polypeptide family, neuropeptide Y, and peptide YY. In Handbook of Physiology: The Gastrointestinal System II. Schultz SG, Makhlouf GM, Eds. Bethesda, MD, American Physiological Society, 1989, p. 475-543
32. Fanelli C, Pampanelli S, Epifano L, Rambotti AM, Ciofetta M, Modarelli F, Di Vincenzo A, Annibale B, Lepore M, Lalli C, et al: Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans. Diabetologia 37:797-807, 1994
33. Vaz M, Cox HS, Kaye DM, Turner AG, Jennings GL, Esler MD: Fallibility of plasma noradrenaline measurements in studying postprandial sympathetic nervous responses. J Auton Nerv Syst 56:97-104, 1995
34. De Feo P, Perriello G, Torlone E, Fanelli C, Ventura MM, Santeusanio F, Brunetti P, Gerich JE, Bolli GB: Contribution of adrenergic mechanisms to glucose counterregulation in humans. Am J Physiol 261:E725-E736, 1991
35. Smith D, Pernet A, Reid H, Bingham E, Rosenthal JM, Macdonald LA, Umpleby AM, Amiel SA: The role of hepatic portal glucose sensing in modulating responses to hypoglycaemia in man. Diabetologia 45:1416-1424, 2002
36. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI: Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184, 1995
37. Fanelli C, Calderone S, Epifano L, De Vincenzo A, Modarelli F, Pampanelli S, Perriello G, De Feo P, Brunetti P, Gerich JE, et al: Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest 92:1617-1622, 1993
38. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J: Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes 43:1311-1317, 1994