Subcellular Localization of Radiolabeled Somatostatin Analogues: Implications for Targeted Radiotherapy of Cancer

Cancer Research

Volumn 63, Issue 20, 2003, Pages 6864-6869

  Wang, Mu ^a   Caruano, Amy L ^a   Lewis, Michael R ^a,c   Meyer, Laura A ^a   VanderWaal, Robert P ^b   Anderson, Carolyn J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,8,11 TETRAAZACYCLOTETRADECANE 1,4,8,11 TETRAACETIC ACID OCTREOTIDE COPPER CU 64; COPPER 64; COPPER ACETATE; PENTETATE OCTREOTIDE INDIUM IN 111; RADIOPHARMACEUTICAL AGENT; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL KILLING; CELL NUCLEUS; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG UPTAKE; IN VITRO STUDY; ISOTOPE LABELING; MITOCHONDRION; NONHUMAN; PANCREAS TUMOR; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; RAT;

ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; COPPER RADIOISOTOPES; OCTREOTIDE; ORGANOMETALLIC COMPOUNDS; PANCREATIC NEOPLASMS; PENTETIC ACID; RADIOPHARMACEUTICALS; RATS; SUBCELLULAR FRACTIONS;

EID: 0142250880     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. 111In-DTPA-Phe1-octreotide: a case history. Ann. N. Y. Acad. Sci., 733: 496-506, 1994.
2. Krenning, E. P., de Jong, M., Kooij, P. P. M., Breeman, W. A. P., Bakker, W. H., de Herder, W. W., van Eijek, C. H. J., Kwekkeboom, D. J., Jamar, F., Pauwels, S., and Valkema, R. Radiolabelled somatostatin analogue(s) for peptide receptor scintigraphy and radionuclide therapy. Ann. Oncol., 10 (Suppl. 2): S23-S29, 1999
3. Hornick, C. A., Anthony, C. T., Hughey, S., Gebhardt, B. M., Espenan, G. D., and Woltering, E. A. Progressive nuclear translocation of somatostatin analogs. J. Nucl. Med., 41: 1256-1263, 2000.
4. 1]-octreotide in patients with neuroendocrine tumors. J. Nucl. Med., 41: 1514-1518, 2000.
5. Anderson, C. J., Pajeau, T. S., Edwards, W. B., Sherman, E. L. C., Rogers, B. E., and Welch, M. J. In vitro and be vivo evaluation of copper-64-labeled octreotide conjugates. J. Nucl. Med., 36: 2315-2325, 1995.
6. Anderson, C. J., Jones, L. A., Bass, L. A., Sherman, E. L. C., McCarthy, D. W., Cutler, P. D., Lanahan, M. V., Cristel, M. E., Lewis, J. S., and Schwarz, S. W. Radiotherapy, toxicity and dosimetry of copper-64-TETA-octreotide in tumor-bearing rats. J. Nucl. Med., 39: 1944-1951, 1998.
7. Anderson, C. J., Dehdashti, F., Cutler, P. D., Schwarz, S. W., Laforest, R., Bass, L. A., Lewis, J. S., and McCarthy, D. W. Copper-64-TETA-octreotide as a PET imaging agent for patients with neuroendocrine tumors. J. Nucl. Med., 42: 213-221, 2001.
8. Connett, J. M., Anderson, C. J., Guo, L. W., Schwarz, S. W., Zinn, K. R., Rogers, B. E., Siegel, B. A., Philpott, G. W., and Welch, M. J. Radioimmunotherapy with a Cu-64-labeled monoclonal antibody: a comparision with Cu-67. Proc. Nat. Acad. Sci. USA, 93: 6814-6818, 1996.
9. Bass, L. A., Wang, M., Welch, M. J., and Anderson, C. J. In vivo transchelation of copper-64 from TETA-octreotide to superoxide dismutase in rat liver. Bioconj. Chem., 11: 527-532, 2000.
10. George, A. M., Sabovljev, S. A., Hart, L. E., Cramp, W. A., Harris, G., and Hornsey, S. DNA quaternary structure in the radiation sensitivity of human lymphocytes - a proposed role of copper. Br. J. Cancer, 55 (Suppl. VIII): 141-144, 1987.
11. Lewis, D. C., and Laemmli, U. K. Higher order chromatin structure: evidence for metallo protein interactions. Cell, 29: 171-181, 1982.
12. Chiu, S. M., Xue, L. Y., Friedman, L. R., and Oleinick, N. L. Chromatin compaction and the efficiency of formation of DNA-protein crosslinks in γ-irradiated mammalian cells. Radiat. Res., 129: 184-191, 1992.
13. Chiu, S-M., Xue, L-Y., Friedman, L. R., and Oleinick, N. L. Copper ion-mediated sensitization of nuclear matrix attachment sites to ionizing radiation. Biochemistry, 32: 6214-6219, 1993.
14. Duncan, J. R., Stephenson, M. T., Wu, H. P., and Anderson, C. J. Indium-111-diethylenectriaminepentaacetic acid-octreotide is delivered in vivo to pancreatic, tumor cell, and hepatocyte lysosomes. Cancer Res., 57: 659-671, 1997.
15. McCarthy, D. W., Shefer, R. E., Klinkowstein, R. E., Bass, L. A., Margenau, W. H., Cutler, C. S., Anderson, C. J., and Welch, M. J. The efficient production of high specific activity Cu-64 using a biomedical cyclotron. Nucl. Med. Biol., 24: 35-43, 1997.
16. Zinn, K. R., Chaudhuri, T. R., Buchsbaum, D. J., Mountz, J. M., and Rogers, B. E. Simultaneous evaluation of dual gene transfer to adherent cells by γ-ray imaging. Nucl. Med. Biol., 28: 135-144, 2001.
17. Li, W. P., Lewis, J. S., Srinivasan, A., Schmidt, M. A., and Anderson, C. J. Copper-64/61 and iodine-125-labeled DOTA-D-TYR1-octreotate: a new somatostatin analaog for labeling with metals and halogens. J. Label. Compd. Radiopharm., 44 (Suppl. 1): S948-S950, 2001.
18. Morton, P. A., Zacheis, M. L., Giacoletto, K. S., Manning, J. A., and Schwartz, B. D. Delivery of nascent MHC class II-invariant chain complexed to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells. J. Immunol., 154: 137-150, 1995.
19. 64Cu-labeled somatostatin analogs in vitro and in a tumor-bearing rat model: evaluation of new derivatives for PET imaging and targeted radiotherapy. J. Med. Chem., 42: 1341-1347, 1999.
20. de Jong, M., Bernard, B. F., de Bruin, E., van Gameren, A., Bakker, W. H., Visser, T. J., Maecke, H. R., and Krenning, E. P. Internalization of radiolabelled [DTPA0]octreotide and [DOTA0, Tyr3]octreotide: peptides for somatostatin receptor-targeted scintigraphy and radionuctide therapy. Nucl. Med. Comm., 19: 283-288, 1998.
21. 1-octreotide. Bioconj. Chem., 9: 192-200, 1998.
22. Chiu, S-M., Zue, L-Y., Friedman, L. R., and Oleinick, N. L. Differential dependence on chromatin structure for copper and iron ion induction of DNA double-strand breaks. Biochemistry, 34: 2653-2661, 1995.
23. Trumbore, C. N. Ehrlich, R. S., and Myers, Y. N. Changes in DNA conformation induced by γ irradiation in the presence of copper. Radiat. Res., 155: 453-465, 2001.
24. Glerum, D. M., Shtanko, A., and Tzagoloff, A. Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase. J. Biol. Chem., 271: 14504-14509, 1996.
25. Koichiro, K., Tsumori, K., Ohmasa, Y., Takahashi, Y., and Munekata, E. The oxpression of Cox17p in rodent tissues and cells. Eur. J. Biochem., 267: 6699-6707, 2000.
26. Bernardi, P., Scorrano, L., Colonna, R., Petronilli, V., and Di Lisa, F. Mitochondria and cell death. Eur. J. Biochem., 264: 687-701, 1999.